Macrophage migration inhibitory factor as an incriminating agent in vitiligo

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarag A.G.A.
dc.contributor.authorHabib M.S.
dc.contributor.authorKamh M.E.
dc.contributor.authorHammam M.A.
dc.contributor.authorElnaidany N.F.
dc.contributor.otherDermatology
dc.contributor.otherAndrology and STDs department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia UniversityEl Menoufia
dc.contributor.otherEgypt; Medical Biochemistry department
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenoufia UniversityEl Menoufia
dc.contributor.otherEgypt; Clinical Pharmacy department
dc.contributor.otherFaculty of Pharmacy-MSA University
dc.contributor.other6th October City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:57Z
dc.date.available2020-01-09T20:40:57Z
dc.date.issued2018
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractBackground: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. Objective: To determine the hypothesized role of migration inhibitory factor in vitiligo via estimation of serum migration inhibitory factor levels and migration inhibitory factor mRNA concentrations in patients with vitiligo compared with healthy controls. We also aimed to assess whether there is a relationship between the values of serum migration inhibitory factor and/ or migration inhibitory factor mRNA with disease duration, clinical type and severity in vitiligo patients. Methods: Evaluation of migration inhibitory factor serum level and migration inhibitory factor mRNA expression by ELISA and real-time PCR, respectively, were performed for 50 patients with different degrees of vitiligo severity and compared to 15 age- and gender-matched healthy volunteers as controls. Results: There was a highly significant increase in serum migration inhibitory factor and migration inhibitory factor mRNA levels in vitiligo cases when compared to controls (p<0.001). There was a significant positive correlation between both serum migration inhibitory factor and migration inhibitory factor mRNA concentrations in vitiligo patients, and each of them with duration and severity of vitiligo. In addition, patients with generalized vitiligo have significantly elevated serum migration inhibitory factor and mRNA levels than control subjects. Study limitations: Small number of investigated subjects. Conclusions: Migration inhibitory factor may have an active role in the development of vitiligo, and it may also be a useful index of disease severity. Consequently, migration inhibitory factor may be a new treatment target for vitiligo patients. � 2018 by Anais Brasileiros de Dermatologia.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24247&tip=sid&clean=0
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24247&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1590/abd1806-4841.20186068
dc.identifier.doiPubMed ID 29723363
dc.identifier.issn3650596
dc.identifier.otherhttps://doi.org/10.1590/abd1806-4841.20186068
dc.identifier.otherPubMed ID 29723363
dc.identifier.urihttps://t.ly/XAjzL
dc.language.isoEnglishen_US
dc.publisherSociedade Brasileira de Dermatologiaen_US
dc.relation.ispartofseriesAnais Brasileiros de Dermatologia
dc.relation.ispartofseries93
dc.subjectMacrophage migration-inhibitory factorsen_US
dc.subjectMessengeren_US
dc.subjectRNAen_US
dc.subjectVitiligoen_US
dc.subjectmacrophage migration inhibition factoren_US
dc.subjectmessenger RNAen_US
dc.subjectadolescenten_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectblooden_US
dc.subjectcase control studyen_US
dc.subjectchilden_US
dc.subjectenzyme linked immunospot assayen_US
dc.subjectfemaleen_US
dc.subjectgene expressionen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectmiddle ageden_US
dc.subjectnonparametric testen_US
dc.subjectpathologyen_US
dc.subjectphysiologyen_US
dc.subjectpreschool childen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectreference valueen_US
dc.subjectseverity of illness indexen_US
dc.subjecttime factoren_US
dc.subjectvitiligoen_US
dc.subjectyoung adulten_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectCase-Control Studiesen_US
dc.subjectChilden_US
dc.subjectChild, Preschoolen_US
dc.subjectEnzyme-Linked Immunospot Assayen_US
dc.subjectFemaleen_US
dc.subjectGene Expressionen_US
dc.subjectHumansen_US
dc.subjectMacrophage Migration-Inhibitory Factorsen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectReal-Time Polymerase Chain Reactionen_US
dc.subjectReference Valuesen_US
dc.subjectRNA, Messengeren_US
dc.subjectSeverity of Illness Indexen_US
dc.subjectStatistics, Nonparametricen_US
dc.subjectTime Factorsen_US
dc.subjectVitiligoen_US
dc.subjectYoung Adulten_US
dc.titleMacrophage migration inhibitory factor as an incriminating agent in vitiligoen_US
dc.typeArticleen_US
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