Olive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activities

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAl-Quraishy S.
dc.contributor.authorOthman M.S.
dc.contributor.authorDkhil M.A.
dc.contributor.authorAbdel Moneim A.E.
dc.contributor.otherDepartment of Zoology
dc.contributor.otherCollege of Science
dc.contributor.otherKing Saud University
dc.contributor.otherRiyadh
dc.contributor.otherSaudi Arabia; Faculty of Preparatory Year
dc.contributor.otherUniversity of Hail
dc.contributor.otherHail
dc.contributor.otherSaudi Arabia; Faculty of Biotechnology
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Zoology and Entomology
dc.contributor.otherFaculty of Science
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:20Z
dc.date.available2020-01-09T20:41:20Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractGastritis is preponderantly characterized by inflammation of the lining epithelial layer and the chronic gastritis is considered as a pre-cancer lesion. For many centuries olive (Olea europaea) leaf has been used for its putative health potential, nonetheless, to date, the gastroprotective effects of olive leaves have not been studied yet. Hence, in this study we investigated whether olive leaf extract (OLE) could protect gastric mucosa against HCl/ethanol-induced gastric mucosal damage in rats. Hcl/ethanol administration caused significant damage to the gastric mucosa, as confirmed by gastric ulcer index and histological evaluation. However, this damage was largely prevented by pre-administering 20�mg/kg omeprazole or 100�mg/kg OLE. Interestingly, the damage was completely prevented by pre-administering 200 and 300�mg/kg OLE. Moreover, OLE attenuated the inflammatory response by decreasing nuclear factor-?B (NF-?B), cycloxygenase-2 (COX-2) and tumor necrosis factor-? (TNF-?) expressions, and down-regulating inducible nitric oxide synthase (iNOS) and interleukin-1? (IL-1?) in gastric mucosa. The gastroprotective mechanism of OLE involved the promotion of enzymatic and nonenzymatic molecules (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione reduced form), promoting nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA expression, halting lipid peroxidation and preventing the overproduction of nitric oxide. Together, our findings clearly demonstrated that OLE could prevent HCl/ethanol-induced gastritis by attenuating inflammation and oxidant/antioxidant imbalance. Indeed, OLE could potentially be useful as a natural therapy for gastritis. � 2017 Elsevier Masson SASen_US
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2017.04.069
dc.identifier.doiPubMedID28463797
dc.identifier.issn7533322
dc.identifier.otherhttps://doi.org/10.1016/j.biopha.2017.04.069
dc.identifier.otherPubMedID28463797
dc.identifier.urihttps://t.ly/YXe0v
dc.language.isoEnglishen_US
dc.publisherElsevier Masson SASen_US
dc.relation.ispartofseriesBiomedicine and Pharmacotherapy
dc.relation.ispartofseries91
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectAntioxidanten_US
dc.subjectGastritisen_US
dc.subjectHCl/ethanolen_US
dc.subjectInflammationen_US
dc.subjectOlive leafen_US
dc.subjectalcoholen_US
dc.subjectcatalaseen_US
dc.subjectcyclooxygenase 2en_US
dc.subjectdigestive tract agenten_US
dc.subjectglutathione peroxidaseen_US
dc.subjectglutathione reductaseen_US
dc.subjecthydrochloric aciden_US
dc.subjectimmunoglobulin enhancer binding proteinen_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectinterleukin 1betaen_US
dc.subjectmessenger RNAen_US
dc.subjectmethanolen_US
dc.subjectnitric oxideen_US
dc.subjectOlea europaea extracten_US
dc.subjectomeprazoleen_US
dc.subjectplant extracten_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttranscription factor Nrf2en_US
dc.subjecttumor necrosis factoren_US
dc.subjectunclassified drugen_US
dc.subjectalcoholen_US
dc.subjectantioxidanten_US
dc.subjecthydrochloric aciden_US
dc.subjectmethanolen_US
dc.subjectplant extracten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdown regulationen_US
dc.subjectenzyme activityen_US
dc.subjectgastritisen_US
dc.subjectlipid peroxidationen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectoliveen_US
dc.subjectplant leafen_US
dc.subjectpriority journalen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectrat modelen_US
dc.subjectstomach mucosaen_US
dc.subjectstomach protectionen_US
dc.subjectstomach ulceren_US
dc.subjectanimalen_US
dc.subjectbody weighten_US
dc.subjectchemically induceden_US
dc.subjectchemistryen_US
dc.subjectdrug effectsen_US
dc.subjectenzymologyen_US
dc.subjectgastritisen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjectinflammationen_US
dc.subjectmetabolismen_US
dc.subjectolive treeen_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectplant leafen_US
dc.subjectstomach ulceren_US
dc.subjecttoxicity testingen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectBody Weighten_US
dc.subjectChromatography, High Pressure Liquiden_US
dc.subjectEthanolen_US
dc.subjectGastritisen_US
dc.subjectHydrochloric Aciden_US
dc.subjectInflammationen_US
dc.subjectMaleen_US
dc.subjectMethanolen_US
dc.subjectOleaen_US
dc.subjectOxidative Stressen_US
dc.subjectPlant Extractsen_US
dc.subjectPlant Leavesen_US
dc.subjectRats, Wistaren_US
dc.subjectStomach Ulceren_US
dc.subjectToxicity Tests, Acuteen_US
dc.titleOlive (Olea europaea) leaf methanolic extract prevents HCl/ethanol-induced gastritis in rats by attenuating inflammation and augmenting antioxidant enzyme activitiesen_US
dc.typeArticleen_US
dcterms.isReferencedByJeon, W.Y., Lee, M.Y., Shin, I.S., Jin, S.E., Ha, H., Curcuma aromatica water extract attenuates ethanol-induced gastritis via enhancement of antioxidant status (2015) Evid. Based Complement. Alter. Med., 2015, p. 582496; El-Serag, H.B., Time trends of gastroesophageal reflux disease: a systematic review (2007) Clin. Gastroenterol. Hepatol., 5 (1), pp. 17-26; Xiang, Z., Si, J.M., Huang, H.D., Chronic gastritis rat model and role of inducing factors (2004) World J. Gastroenterol., 10 (21), pp. 3212-3214; Sostres, C., Gargallo, C.J., Lanas, A., Interaction between Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs and/or low-dose aspirin use: old question new insights (2014) World J. Gastroenterol., 28 (20), pp. 9439-9450; Kim, B., Yim, S., Jeong, S., Choi, Y., Nam, Y., Jeong, J., Yun, S., Park, E., Pro-oxidantive effect of dehydroepiandrosterone on indomethacin-induced acute gastritis in rats (2009) Biomol Ther, 17 (1), pp. 57-61; Bhattacharyya, A., Chattopadhyay, R., Mitra, S., Crowe, S.E., Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases (2014) Physiol. Rev., 94 (2), pp. 329-354; Ding, S.Z., Minohara, Y., Fan, X.J., Wang, J., Reyes, V.E., Patel, J., Dirden-Kramer, B., Crowe, S.E., Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells (2007) Infect. Immun., 75 (8), pp. 4030-4039; de Bock, M., Derraik, J.G., Brennan, C.M., Biggs, J.B., Morgan, P.E., Hodgkinson, S.C., Hofman, P.L., Cutfield, W.S., Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial (2013) PLoS One, 8 (3), p. e57622; El, S.N., Karakaya, S., Olive tree (Olea europaea) leaves: potential beneficial effects on human health (2009) Nutr. Rev., 67 (11), pp. 632-638; Meirinhos, J., Silva, B.M., Valentao, P., Seabra, R.M., Pereira, J.A., Dias, A., Andrade, P.B., Ferreres, F., Analysis and quantification of flavonoidic compounds from Portuguese olive (Olea europaea L.) leaf cultivars (2005) Nat. Prod. Res., 19 (2), pp. 189-195; Sudjana, A.N., D'Orazio, C., Ryan, V., Rasool, N., Ng, J., Islam, N., Riley, T.V., Hammer, K.A., Antimicrobial activity of commercial Olea europaea (olive) leaf extract (2009) Int. J. Antimicrob. Agents, 33 (5), pp. 461-463; Grizis, C., Atta-Politou, J., Koupparis, M.A., Simultaneous determination of oleuropein and tyrosol in plasma using high performance liquid chromatography with UV detection (2003) J. Liq. Chromatogr. Relat. Technol., 26 (4), pp. 599-616; Abdel Moneim, A.E., Indigofera oblongifolia prevents lead acetate-Induced hepatotoxicity, oxidative stress, fibrosis and apoptosis in rats (2016) PLoS One, 11 (7), p. e0158965; Cavallini, M.E., Andreollo, N.A., Metze, K., Ara�jo, M.R., Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats (2006) Acta Cir. Bras., 21, pp. 168-176; Son, D.J., Lee, G.R., Oh, S., Lee, S.E., Choi, W.S., Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents (2015) Nutrients, 7 (3), pp. 1945-1964; Arab, H.H., Salama, S.A., Omar, H.A., Arafa el, S.A., Maghrabi, I.A., Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions (2015) PLoS One, 10 (3), p. e0122417; Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193 (1), pp. 265-275; Ohkawa, H., Ohishi, N., Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction (1979) Anal. Biochem., 95 (2), pp. 351-358; Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R., Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids (1982) Anal. Biochem., 126 (1), pp. 131-138; Sedlak, J., Lindsay, R.H., Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent (1968) Anal. Biochem., 25 (1), pp. 192-205; Nishikimi, M., Appaji, N., Yagi, K., The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen (1972) Biochem. Biophys. Res. Commun., 46 (2), pp. 849-854; Aebi, H., Catalase in vitro (1984) Methods Enzymol., 105, pp. 121-126; Paglia, D.E., Valentine, W.N., Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase (1967) J. Lab. Clin. Med., 70 (1), pp. 158-169; Factor, V.M., Kiss, A., Woitach, J.T., Wirth, P.J., Thorgeirsson, S.S., Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis (1998) J. Biol. Chem., 273 (25), pp. 15846-15853; Bradley, P.P., Priebat, D.A., Christensen, R.D., Rothstein, G., Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker (1982) J. Invest. Dermatol., 78 (3), pp. 206-209; Ortega-Garcia, F., Blanco, S., Peinado, M.A., Peragon, J., Polyphenol oxidase and its relationship with oleuropein concentration in fruits and leaves of olive (Olea europaea) cv. �Picual� trees during fruit ripening (2008) Tree Physiol., 28 (1), pp. 45-54; Suo, H., Zhao, X., Qian, Y., Sun, P., Zhu, K., Li, J., Sun, B., Lactobacillus fermentum suo attenuates HCl/ethanol induced gastric injury in mice through its antioxidant effects (2016) Nutrients, 8 (3), p. 155; Sangiovanni, E., Vrhovsek, U., Rossoni, G., Colombo, E., Brunelli, C., Brembati, L., Trivulzio, S., Dell'Agli, M., Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies (2013) PLoS One, 8 (8), p. e71762; Konturek, P.C., Duda, A., Brzozowski, T., Konturek, S.J., Kwiecien, S., Drozdowicz, D., Pajdo, R., Hahn, E.G., Activation of genes for superoxide dismutase, interleukin-1beta, tumor necrosis factor-alpha, and intercellular adhesion molecule-1 during healing of ischemia-reperfusion-induced gastric injury (2000) Scand. J. Gastroenterol., 35 (5), pp. 452-463; Chen, S., Zhu, K., Wang, R., Zhao, X., Preventive effect of polysaccharides from the large yellow croaker swim bladder on HCl/ethanol induced gastric injury in mice (2014) Exp. Ther. Med., 8 (1), pp. 316-322; Kornman, K.S., Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of aging (2006) Am. J. Clin. Nutr., 83 (2), pp. 475S-483S; Boss, A., Bishop, K.S., Marlow, G., Barnett, M.P., Ferguson, L.R., Evidence to support the anti-cancer effect of olive leaf extract and future directions (2016) Nutrients, 8 (8); Cherdantseva, L.A., Potapova, O.V., Sharkova, T.V., Belyaeva, Y.Y., Shkurupiy, V.A., Association of Helicobacter pylori and iNOS production by macrophages and lymphocytes in the gastric mucosa in chronic gastritis (2014) J. Immunol. Res., 2014, p. 762514; Khalatbary, A.R., Zarrinjoei, G.R., Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma (2012) Iran. Red. Crescent Med. J., 14 (4), pp. 229-234; Bitler, C.M., Viale, T.M., Damaj, B., Crea, R., Hydrolyzed olive vegetation water in mice has anti-inflammatory activity (2005) J. Nutr., 135 (6), pp. 1475-1479; Moudache, M., Colon, M., Nerin, C., Zaidi, F., Phenolic content and antioxidant activity of olive by-products and antioxidant film containing olive leaf extract (2016) Food Chem., 212, pp. 521-527; Visioli, F., Bellosta, S., Galli, C., Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages (1998) Life Sci., 62 (6), pp. 541-546; Li, H.L., Sun, B.Z., Ma, F.C., Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma (2004) World J. Gastroenterol., 10 (13), pp. 1862-1866; Sulzbach, D.E.O.H.S., Biolchi, V., Richardt Medeiros, H.R., Bizerra Gandor Jantsch, D.B., Knabben, D.E.O.B.D.L.K., Reckziegel, R., Goettert, M.I., Pozzobon, A., Effect of helicobacter pylori on NFKB1, p38alpha and TNF-alpha mRNA expression levels in human gastric mucosa (2016) Exp. Ther. Med., 11 (6), pp. 2365-2372; Samaka, R.M., Abdou, A.G., Abd El-Wahed, M.M., Kandil, M.A., El-Kady, N.M., Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters (2006) J. Egypt. Nat. Cancer Inst., 18 (4), pp. 363-374; Zhao, W., Zhu, F., Shen, W., Fu, A., Zheng, L., Yan, Z., Zhao, L., Fu, G., Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats (2009) Acta Biochim. Biophys. Sin. (Shanghai), 41 (4), pp. 301-308; Lee, S.E., Song, H.J., Park, S.Y., Nam, Y., Min, C.H., Lee, D.Y., Jeong, J.Y., Sohn, U.D., Effect of ECQ on iodoacetamide-induced chronic gastritis in rats (2013) Korean J. Physiol. Pharmacol., 17 (5), pp. 469-477; Bayram, B., Ozcelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I.M., Wagner, A.E., Rimbach, G., A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression (2012) Rejuvenation Res., 15 (1), pp. 71-81; Paredes-Gonzalez, X., Fuentes, F., Jeffery, S., Saw, C.L., Shu, L., Su, Z.Y., Kong, A.N., Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin (2015) Biopharm. Drug Dispos., 36 (7), pp. 440-451; Boss, A., Kao, C.H., Murray, P.M., Marlow, G., Barnett, M.P., Ferguson, L.R., Human intervention study to assess the effects of supplementation with olive leaf extract on peripheral blood mononuclear cell gene expression (2016) Int. J. Mol. Sci., 17 (12)
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