The synergistic effect of biosynthesized silver nanoparticles from a combined extract of parsley, corn silk, and gum arabic: In vivo antioxidant, anti-inflammatory and antimicrobial activities

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorHelmy, A
dc.contributor.authorEl-Shazly, M
dc.contributor.authorSeleem, A
dc.contributor.authorAbdelmohsen, U
dc.contributor.authorSalem, M.A
dc.contributor.authorSamir, A
dc.contributor.authorRabeh, M
dc.contributor.authorElshamy, A
dc.contributor.authorSingab, A.N.B
dc.date.accessioned2020-03-25T09:13:11Z
dc.date.available2020-03-25T09:13:11Z
dc.date.issued2020
dc.descriptionScopusen_US
dc.description.abstractView references (62) Microbial resistance, oxidative stress, and inflammatory conditions are among the leading causes of death worldwide. In the current work, silver nanoparticles (AgNPs) were biosynthesized using the aqueous extracts of parsley, corn silk (CS), gum Arabic (GA) or combination of the three extracts. The formed nanoparticles were characterized using three techniques including transmission electron microscopy (TEM), UV-visible spectrophotometer and Fourier-transform infrared spectroscopy (FTIR). The antioxidant, anti-inflammatory, and antimicrobial activities were tested for the formed nanoparticles, the aqueous extracts of each of the three plants and their combination. Oxidative stress was induced by alloxan which promoted the development of diabetes mellitus in rats. Inflammation was induced by injecting carrageenan in rats' paws. Pathogenic microorganisms causing serious urinary tract infection (UTI) were selected for the antimicrobial assay. All aqueous extracts and the biosynthesized AgNPs showed variable degrees of antioxidant, anti-inflammatory and antimicrobial activities, however, the AgNPs biosynthesized by the combination of the three aqueous extracts was the most effective one. LC/MS was done to identify the compounds present in the crude extracts that may be responsible for the observed biological activities. LC/MS resulted in the identification of 13 compounds. Docking experiments on COX-1 (cyclooxygenase-1) and COX-2 (cyclooxygenase-2) were performed to determine the compounds responsible for the anti-inflammatory activity of the extracts. The results showed that silver nanoparticles synthesized by the combination of the three aqueous extracts are considered promising candidates for the development of antioxidant, anti-inflammatory and antimicrobial agentsen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100432452&tip=sid&clean=0
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dc.identifier.doihttps://doi.org/10.1088/2053-1591/ab6e2d
dc.identifier.issn20531591
dc.identifier.otherhttps://doi.org/10.1088/2053-1591/ab6e2d
dc.identifier.urihttps://t.ly/rq1gR
dc.language.isoen_USen_US
dc.publishernstitute of Physics Publishingen_US
dc.relation.ispartofseriesMaterials Research Express;Volume 7, Issue 2, 2020, Article number 025002
dc.subjectuniversity of anti-inflammatoryen_US
dc.subjectantimicrobialen_US
dc.subjectantioxidanten_US
dc.subjectcorn silken_US
dc.subjectgum Arabicen_US
dc.subjectparsleyen_US
dc.subjectsilver nanoparticlesen_US
dc.titleThe synergistic effect of biosynthesized silver nanoparticles from a combined extract of parsley, corn silk, and gum arabic: In vivo antioxidant, anti-inflammatory and antimicrobial activitiesen_US
dc.typeArticleen_US

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