Square wave voltammetric determination of rasagiline mesylate on hanging mercury drop electrode and its application in dosage form and biological fluids

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Date

2016

Journal Title

Journal ISSN

Volume Title

Type

Article

Publisher

Institute of Electrical and Electronics Engineers Inc.
Electrochemical Science Group

Series Info

International Journal of Electrochemical Science
11

Abstract

A new square wave voltammetric (SWV) method has been developed and validated for the determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4 x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The accuracy and precision of the method were within acceptable limits. The method was applied for determining the active ingredients in its tablets with % recoveries � relative standard deviation of 95.46 � 3.7 6 and in spiked human plasma with 94.3 � 2.8 9%, respectively. � 2016 The Authors.

Description

Scopus

Keywords

October University for Modern Sciences and Arts, جامعة أكتوبر للعلوم الحديثة والآداب, University of Modern Sciences and Arts, MSA University, Acetylene group, Hanging mercury drop electrode, Rasagiline mesylate, Square wave voltammetry

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