Square wave voltammetric determination of rasagiline mesylate on hanging mercury drop electrode and its application in dosage form and biological fluids
Date
2016
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Institute of Electrical and Electronics Engineers Inc.
Electrochemical Science Group
Electrochemical Science Group
Series Info
International Journal of Electrochemical Science
11
11
Scientific Journal Rankings
Abstract
A new square wave voltammetric (SWV) method has been developed and validated for the determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4 x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The accuracy and precision of the method were within acceptable limits. The method was applied for determining the active ingredients in its tablets with % recoveries � relative standard deviation of 95.46 � 3.7 6 and in spiked human plasma with 94.3 � 2.8 9%, respectively. � 2016 The Authors.
Description
Scopus
Keywords
October University for Modern Sciences and Arts, جامعة أكتوبر للعلوم الحديثة والآداب, University of Modern Sciences and Arts, MSA University, Acetylene group, Hanging mercury drop electrode, Rasagiline mesylate, Square wave voltammetry