MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 140
A Full content for MSA university Faculties Journals
MSA Theses 5
A digital collection of MSA University postgraduate theses, including PhD and Master’s theses, organized by academic degree and faculty.
MSA University Academic Graduation Projects 1153
A Full content for msa university Distinguished Graduation Projects Yearbook
MSA University Academic Research 3735
MSA University Campus 2
Images for MSA University " sites - building - landscape "

Recent Submissions

Nanozymes as Emerging Therapeutics for Asthma: A Redox-Responsive and Immunomodulatory Strategy
(Multidisciplinary Digital Publishing Institute (MDPI), 2026-05-14) Manar T. El-Morsy; Nadine M. Askar; Ali Emad Khurkhash; Nagm Al-Din Mahrous; Yusuf Ahmed Elberry; Mohamed Ramadan Sayed; Norhan Ashraf Ahmed; Rowayda A. Ahmed; Yehia S. Mohamed; Sinclair Steele; Ahmad Ahmeda; Rudaynah Mohamed; Doaa S. R. Khafaga
Asthma is a chronic, etiologically diverse lung disease that contributes to worldwide morbidity and healthcare burdens. Although bronchodilators and corticosteroids remain the cornerstones of asthma treatment, their long-term use is associated with significant side effects. Furthermore, steroid resistance in severe asthma emphasizes the need for alternative therapeutic approaches. Nanotechnology has emerged as a viable alternative to these standard approaches, allowing for targeted, prolonged, and precise drug delivery. Nanozymes, or synthetic nanomaterials that imitate natural enzyme functions, are gaining popularity among nanomedicine platforms due to their redox-regulating and immunomodulatory properties. This review provides a comprehensive overview of the present landscape of nanozyme-based treatments for asthma, with a focus on carbon-based nanozymes, while discussing MOF-derived and single-atom nanozymes in terms of their physicochemical properties and potential applicability to airway inflammatory diseases. Moreover, we look at current advancements in nanozyme-enabled drug delivery systems, their biocompatibility profiles, and potential strategies for designing nanozyme therapies according to asthma endotypes. These findings establish nanozymes as a transformational and therapeutically promising platform for next-generation asthma treatment.
Association of vitamin B1/B6/B12 supplementation with sphingosine-1-phosphate signaling and its receptors in multiple sclerosis patients: relevance to LISPR1 and APOA1-AS
(Portland Press Ltd, 2026-05-21) Noha A. Mehana; Heba R. Ghaiad; Mohammed M. Nooh; Mai A. Amer; Lobna Talaat El-Ghoneimy; Maheera H. Safwat
MS is a lifelong autoimmune disorder striking the central nervous system (CNS). Despite the currently used disease-modifying therapies, patients are exposed to persistent neuropathy, pinpointing the need for supportive therapy. Neurotropic vitamins B1, B6, and B12 have been used to offer relief from immunological and neurological MS manifestations. The present study aimed to provide some mechanistic insights into the relationship of B1/B6/B12 vitamin supplementation with the development of MS regarding lipid metabolism and epigenetics. In this cross-sectional observational study, blood samples were obtained from 53 MS patients, including 25 patients, who had received daily vitamin B1/B6/B12 supplementation for over six months and 28 patients without supplementation. Plasma sphingosine-1-phosphate (S1P) and S1P receptor-1 (S1PR1) levels, lipid profile, and gene expression of ApoA1, sphingosine kinases 1&2 (SPHK1&2), S1PR1, as well as the lncRNAs APOA1-AS and LISPR1 were evaluated. Gene ontology and KEGG pathway enrichment analyses were conducted. Vitamin B1/B6/B12 supplementation was associated with a more favorable lipid profile. Supplemented patients also exhibited higher ApoA1 and lower APOA1-AS expressions compared with non-supplemented patients. Additionally, vitamin B1/B6/B12 supplementation was associated with lower expression levels of SPHK1, SPHK2, LISPR1, and S1PR1 and reduced circulating S1P concentrations. These findings imply significant associations between long-term vitamin B1/B6/B12 supplementation and alterations in lipid-related markers and sphingosine-associated signaling in MS patients. However, the observational design, selection bias, and small sample size limit causal inference and may not fully capture the heterogeneity of MS population. Besides, supplement adherence was self-reported and not objectively verified, and circulating vitamin levels were not measured.
Assessment of Accuracy and Orbital Volume Using Patient-Specific Titanium Implant Versus Patient-Specific Zirconia Implant for Orbital Floor Reconstruction in Blowout Fractures: A Randomized Clinical Trial
(Lippincott Williams and Wilkins, 2026-05-25) Ola Alaa El Morsy; Sameh Mekhemar; Mohamed Mounir; Shady El Assiouty; Samy Mounir
This randomized clinical trial aimed to compare patient-specific titanium and zirconia implants for orbital floor reconstruction with respect to reconstruction accuracy, orbital volume restoration, patient satisfaction, and cost-effectiveness. Twenty-four patients presenting with orbital blowout fractures underwent open reduction and internal fixation with orbital floor and/or medial wall reconstruction using patient-specific implants through a transconjunctival approach. Virtual surgical planning was performed by mirroring the contralateral intact orbit combined with digital fracture reduction. Postoperative evaluation included orbital volume measurements and 3-dimensional superimposition analysis to assess reconstruction accuracy. Patient satisfaction and implant manufacturing cost were also recorded. Both zirconia and titanium implants achieved comparable restoration of orbital volume and reconstruction accuracy, with no statistically significant differences between groups. Patient satisfaction scores were better in the zirconia group, although the difference was not statistically significant. Postoperative complications occurred only in the titanium group, including one case of globe restriction requiring partial implant removal and 2 cases suggestive of titanium hypersensitivity managed medically. Zirconia implants demonstrated a significantly lower manufacturing cost. Zirconia patient-specific implants provide anatomic and clinical outcomes similar to titanium implants, with a favorable cost profile, supporting their use as a viable alternative for orbital reconstruction.
Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations
(Nature Research, 2026-05-18) Ashraf S. A. El-Sayed; Moustafa O.Aboelez; Hend A. A. Ezelarab; Tassneim M. Ewedah; Ashraf F. El-Baz; Radwa Ashraf; Ayman Diab; Gehan Safwat; Amgad M. Rady; Rasha M. El-Mekkawy
The drug resistance is one of the challenges in cancer chemotherapy, due to the development of different drug-efflux pumps that expels the drug out of the cells, thus, searching for new compounds with multiple targets in tumor cells, could be an affordable chemotherapy. Alternariol monomethyl ether (AME) was preliminary recognized as a cytotoxic compound, however, its availability and equivocal activity are the hurdles for further applications. Alternaria alternata EFBL-025, PV342518.1, endophyte of Catharanthus roseus, exhibited the highest AME productivity (550 μg/l). Chemically, the structure of putative compound of A. alternata was committed from the TLC, HPLC and LC-MS/MS, with molecular mass 274.2 m/z, and typical fragmentation pattern of authentic AME. The purified AME of A. alternata exhibited a substantial activity against the MCF-7 (IC50 2.5 μM), HepG-2 (IC50 3.5 μM), Caco2 (IC50 3.9 μM), compared to OEC (IC50 13.5 μM), i.e with selectivity indices 5.4, 3.9 and 3.5, respectively. The AME has a highest inhibitory activity of Topoisomerase II (IC50 10.2 nM), than Topoisomerase I (IC50 16.7 nM), with a noticeable ability to arrest the division of MCF-7 cells at the G2/M and S phases by 1.5 and 2 folds, respectively, compared to the control. The AME of A. alternata significantly induces the total apoptosis, early apoptosis and necrosis of MCF-7 by 20, 22 and 2.9 folds. The docking analysis showed that AME had a favorable binding affinity for topoisomerases I/II with binding scores -7.72 and -6.06 kcal/mol, normalized to camptothecin and etoposide that have binding scores -9.44 and -6.82 kcal/mol, respectively. The molecular dynamics simulations explored the reliable stability of protein-AME complexes.
Development and evaluation of a propolis, tea tree oil, and jojoba oil nanoemulgel with enhanced antioxidant, anti-inflammatory, and wound-healing activities
(Nature Research, 2026-05-25) Mariam H. Saad; Soha M. Kandil; A. Farid; Gehan Safwat; Ayman A. Diab; Mohamed Taha
The wound healing’s acceleration depends on developing an innovative therapeutic strategy that reduces inflammation, regulates oxidative stress, promotes fibroblast proliferation, and collagen deposition. This study aimed to prepare and evaluate a green nanoemulsion-based formulation containing propolis, tea tree, and jojoba oils to integrate their biological activities for enhanced wound healing efficacy. Nanoemulsion formulations were prepared via a low-energy emulsification approach and characterized by zeta potential, hydrodynamic size (DLS), polydispersity index (PDI), and transmission electron microscopy (TEM). The in vitro antioxidant and anti-inflammatory activities were assessed. In addition, cytotoxicity was assessed using the MTT colorimetric assay against the HSF-1 normal skin cell line. Additionally, NO and IL-1β levels were measured on NHDF-Ad cells. A propolis nanoemulgel (PNEG) was produced using Carbopol 940 as a gelling agent. The in vivo wound healing efficacy of PNEG was tested by evaluating wound closure rate, malondialdehyde, superoxide dismutase, tumor necrosis factor-alpha, and histopathological alterations in healed tissues. The obtained results demonstrated that, the optimized formula displayed a zeta potential of − 28.6 ± 1.91 mV, a DLS of 187.8 ± 3.29 nm, and a 50% cytotoxic concentration (CC50) of 24.82 ± 0.16% and showed a significant antioxidant and anti-inflammatory activities. Furthermore, NO and IL-1β levels were significantly decreased by 35% and 40%, respectively, demonstrating potent anti-inflammatory activity. Additionally, the therapeutic activity was associated with inhibition of IL-1β/NO-driven inflammatory signaling, suppression of NF-κB, activation of the NRF2/HO-1 antioxidant axis, and modulation of BAX/Bcl-2 apoptotic pathways. The in vivo results indicated that PNEG accelerates wound closure significantly compared with both positive and negative control groups. SOD level increased significantly (p < 0.05), whereas MDA and TNF-α levels decreased compared with the control groups (p < 0.05). Furthermore, histopathological examination illustrated infiltration reduction of inflammatory cells, increased collagen deposition, and fast epithelialization. The developed green formula, resulting from both the low-energy, environmentally friendly preparation method and the natural origin of its constituents, was demonstrated to be an antioxidant and inflammatory and to accelerate wound healing, suggesting it could be used as a natural formula for topical wound healing application.