MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 140
A Full content for MSA university Faculties Journals
MSA Theses 5
A digital collection of MSA University postgraduate theses, including PhD and Master’s theses, organized by academic degree and faculty.
MSA University Academic Graduation Projects 1153
A Full content for msa university Distinguished Graduation Projects Yearbook
MSA University Academic Research 3777
MSA University Campus 2
Images for MSA University " sites - building - landscape "

Recent Submissions

Induction of diferential cytotoxicity and ROS‑driven severe genomic DNA damage and intrinsic mitochondrial apoptosis by erbium oxide nanoparticles in p53‑compromised human NSCLC cells
(Springer Science and Business Media Deutschland GmbH, 2026-07-23) Hanan R. H. Mohamed; Alaa H. Elsewedy; Shahd Mosaad; Aya A. Osman; Habiba M. Zaki; Mayada E. Borai; Ayman Diab; Gehan Safwat
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, with current therapeutic strategies limited by systemic toxicity, drug resistance, and poor tumor selectivity. These limitations highlight the urgent need for safer, targeted therapeutic strategies. In this context, erbium oxide nanoparticles (Er2O3NPs) have attracted attention in biomedical research due to their unique physicochemical characteristics, yet their potential as anticancer agents against NSCLC remains fully unexplored. This study was consequently conducted to assess the anticancer efficacy and underlying mechanisms of Er2O3NPs in human A549 NSCLC cells, alongside with evaluating their safety in normal WI-38 lung fibroblasts. Cytotoxicity was determined using the MTT assay, and genomic DNA integrity was assessed via the alkaline Comet assay. Oxidative stress and mitochondrial function were evaluated through 2′,7′-dichlorodihydrofluorescein diacetate (2,7-DCFH-DA) and Rhodamine-123 staining, respectively. Apoptotic induction was analyzed using DAPI nuclear staining and chromatin diffusion assays, while qRT-PCR quantified the expression of apoptosis- and mitochondria-related genes. Er2O3NPs exhibited concentration-dependent cytotoxicity in A549 cells (IC50 = 93.46 µg/ml) and lower toxicity in WI-38 fibroblasts (IC50 = 147.5 µg/ml), yielding a selectivity index of 1.58. Mechanistically, treating A549 cells at the IC50 concentration for 72 h induced severe genomic DNA damage, excessive ROS generation, and pronounced mitochondrial membrane depolarization. DAPI staining revealed characteristic apoptotic nuclear changes, including chromatin condensation and fragmentation, while the chromatin diffusion assay demonstrated extensive DNA dispersion indicative of advanced apoptotic DNA degradation. Moreover, qRT-PCR analysis showed significant downregulation of p53, Bcl-2, and ND3 gene expression. Given the inherent mutant p53 status of A549 cells, this transcriptional downregulation indicates that Er2O3NPs bypass canonical wild-type p53 transcriptional activation, triggering instead an ROS-driven intrinsic mitochondrial apoptotic signaling pathway. In conclusion, Er2O3NPs induce preferential cytotoxicity in NSCLC cells through ROS-mediated severe genomic DNA damage and intrinsic mitochondrial dysfunction within a p53-compromised genetic background. These findings suggest that Er2O3NPs hold potential as a nanotherapeutic candidate for NSCLC. However, further in vivo studies, targeted delivery systems, and direct protein-level evaluations are warranted to fully clarify these mechanisms and advance their clinical applicability.
Biomass pyrolysis over ZIF-67 catalyst: thermogravimetric, pyrolysis vapors, kinetics, thermodynamics and artificial neural network modelling
(Elsevier Ltd, 2026-07-22) Samy Yousef; Vilmantė Kudelytė; Nerijus Striūgas; Mohammed Ali Abdelnaby
Zeolite Imidazole Frame-67 (ZIF-67), a thermally stable subclass of metal-organic frameworks (MOFs), has recently emerged as a promising flexible catalyst for upgrading biomass pyrolysis process and reducing reaction complexity. This research explores the catalytic pyrolysis behavior of wood pellets (WP) biomass over ZIF-67 using thermogravimetric analysis (TGA), TG-Fourier Transform Infrared (TG-FTIR) spectroscopy, and gas chromatography-mass spectrometry (GC-MS). Thermal decomposition kinetics and thermodynamic parameters were evaluated using serval modelling approaches, while artificial neural network (ANN) technique was employed to predict pyrolysis behaviour of WP and ZIF-67/WP samples under untested conditions. Biomass samples containing 10, 20 and 30 wt% ZIF-67 were examined to determine the optimum catalyst loading. The TGA results revealed that biomass underwent thermal decomposition below 600 °C, with a mass loss of 77-86 wt%, followed by the decomposition of ZIF-67 at higher temperatures. The addition of ZIF-67 significantly influenced the composition of the evolved vapors, with 20 wt% catalyst providing the highest catalytic activity by promoting the formation of naphthalene, 1,2,3,4 tetrahydro-2-phenyl-rich vapor, which accounted for approximately 85% of the total identified aromatic GC-MC peak area under the investigated conditions. Kinetics analysis demonstrated that the optimum ZIF-67 loading reduced the activation energy from 233 to 427 kJ/mol (WP) to 159-295 kJ/mol, indicating a substantial reduction in the energy barrier of pyrolysis. Furthermore, the catalyst lowered thermodynamics parameters (enthalpy, Gibbs free energy, and entropy), confirming improved reaction feasibility. The constructed ANN models accurately predicted the pyrolysis behaviour of both WP and ZIF-67/WP samples, achieving R2 exceeding 0.9999. These results demonstrate that incorporating 20 wt% of ZIF-67 into the biomass pyrolysis process effectively reduces the reaction energy requirements and enhances the selectivity of pyrolysis vapors towards valuable aromatic hydrocarbons, highlighting its potential as an efficient catalyst for sustainable biomass valorisation and the production of advanced biofuels and renewable chemicals.
Acupuncture combined with moxibustion therapy for acne vulgaris among adolescents: A randomized controlled trial
(Churchill Livingstone, 2026-07-18) Siham M. Fahmy; Reham M. Abdelrahim; Ahmed M. Tawfick; Marian M. Shafeek
Objective: To assess the efficacy of acupuncture combined with moxibustion compared to standard medical treatments for alleviating symptoms of moderate to severe acne vulgaris in adolescents. Methods: One hundred adolescents with moderate to severe acne vulgaris randomly assigned to the control group received conventional medications, and the experimental group received acupuncture with moxibustion therapies three times weekly. Both groups received interventions for four weeks. The main outcome was assessed by grading and counting inflammatory lesions, and the secondary outcomes were assessed by the Skindex-16 scale in both groups before and after the intervention period. Results: Both groups demonstrated significant improvement following treatment (p < 0.001). The experimental group showed significantly greater improvement in outcomes in the Skindex-16 emotional and total scores (p < 0.001), as well as functional scores (p = 0.001), while no significant differences were observed between the groups in symptom scores (p = 0.079) or lesion counts (p = 0.239). The percentage of improvement showed greater reductions across all measured outcomes in the experimental group, with statistically significant differences observed in most domains. Conclusion: Acupuncture and moxibustion effectively improve both skin lesions and psychosocial well-being in adolescents with acne vulgaris.
Performance Of Flowable Giomer Versus Nanofilled Flowable Composite With Or Without Giomer Coat In Conservative Occlusal Cavities: 18 Months Randomized Clinical Trial
(Cairo University, Faculty of Dentistry, 2026-07-01) Amina Ahmed Gaafar; Eman Aly Abouauf; Hebaallah Mohamed Taher
Aim: This study was conducted to evaluate clinical performance of flowable giomer and flowable resin composite coated with S-PRG in comparison to flowable resin composite as a preventative resin restoration in patients requiring minimally invasive simple class I cavities in permanent molars over 18 months test period. Subjects and methods: Patients with occlusal cavities in permanent molars with ICDAS score 2, were randomly assigned into three groups (n=14 each group, total =42). Group A1 received Flowable giomer, group A2 received Flowable Resin Composite with S-PRG coat applied biannually and group A3 (control) received flowable resin composite. All materials were utilized using the manufacturers’ instructions. Evaluation of restoration was carried out using FDI criteria and probes. Incidence of new carious lesions was evaluated using DIAGNOdent pen. All outcomes were measured at baseline (1 week after placement), after 6, 12, and 18 months. Results: DIAGNOdent scores showed significant intragroup improvements over time, while intergroup differences emerged at later follow-ups. Based on FDI criteria, no significant differences were found between materials. All restorations demonstrated 100% success and survival at 18 months. Conclusion: All tested materials showed similar clinical performance and absence of incidence of new carious lesions after 18 months follow-up.
Heavy Metal Adsorption on Microplastics: Adsorption Mechanisms, Influencing Factors, Analytical Techniques, Toxicological Implications, and Remediation Strategies
(John Wiley and Sons Inc, 2026-07-21) Amr G. Dardeer; Nashwa A. Shaaban; Ahmed Tawfik; Mohamed A. Hassaan; Uyiosa Osagie Aigbe; Ahmed El Nemr
Microplastics (MPs) act as reactive surfaces and carriers in aquatic systems, influencing the mobility, bioavailability, and toxicity of heavy metals. Recent research has clarified how heavy metals adsorb onto MPs, focusing on adsorption pathways, physicochemical factors, analytical methods, toxicological impacts, and remediation strategies. Metal binding to MPs depends on factors such as polymer type, particle size, aging, surface properties, zeta potential, pH, salinity, dissolved organic matter, temperature, and the presence of biofilms. Adsorption occurs through mechanisms including electrostatic interactions, surface complexation, ion exchange, pore filling, hydrogen bonding, van der Waals forces, cation–π interactions, surface precipitation, and biofilm-mediated binding. MP–metal interactions vary with environmental conditions; for example, salinity and dissolved organic matter can enhance or reduce adsorption, depending on metal speciation, polymer characteristics, and experimental conditions. Toxicological studies show that MPs carrying heavy metals can increase bioaccumulation and combined toxicity by promoting transport and cellular uptake. However, strong adsorption and limited desorption may sometimes reduce the bioavailability of dissolved metals. The Mediterranean Sea is a key case study due to its semi-enclosed nature, high urbanization, maritime activity, wastewater discharge, and significant plastic pollution, all of which heighten the importance of MP–metal interactions. There is an urgent need for standardized adsorption protocols, thorough in situ and ex situ characterization, ecologically relevant toxicological studies, and integrated remediation strategies addressing both MPs and associated heavy metals.