MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 141
A Full content for MSA university Faculties Journals
MSA Theses 5
A digital collection of MSA University postgraduate theses, including PhD and Master’s theses, organized by academic degree and faculty.
MSA University Academic Graduation Projects 1153
A Full content for msa university Distinguished Graduation Projects Yearbook
MSA University Academic Research 3827
MSA University Campus 2
Images for MSA University " sites - building - landscape "

Recent Submissions

Driving logistics and supply chain agility through supply chain digital transformation strategy implementation with the moderating role of pharmaceutical supply chains internationalization
(October University for Modern Sciences and Arts MSA , Faculty of Management Sciences, 2026-08) Heba Mohamed Adel; Salma Badawi Fathi; Muhammad Salah Nafea; Safwat Adel El-Sharkawy
The purpose of this research paper is to study the impact of implementing supply chain digital transformation strategy (SCDTSI) on fostering the logistics and supply chain agility (LSCA). It investigates the moderating effect of logistics and supply chain internationalization (LSCI) on the SCDTSI-LSCA relationship across the global pharmaceutical supply chains in Egypt. After conducting a bibliometric thematic analysis, the authors detected and bridged theoretically three active literature research themes on logistics and supply chain digital transformation, agility, and internationalization. A research model was generated and tested empirically using 250 questionnaires answered by logistics and supply chain managers at 50 international, digital, and agile pharmaceutical supply chains operating in Egypt and globally. Quantitative data were analyzed using structural equation modeling by SmartPLS-v4. Results indicated that SCDTSI has a significant positive impact on LSCA, and LSCI was found to be a significant moderator in the SCDTSI-LSCA relationship. Adopting a mixed methods approach, the authors started with exploratory then explanatory qualitative interviews with logistics and supply chain experts to obtain a comprehensive analysis of this technologically-evolving industry. The authors contributed graphically by illustrating a supply chain map of these internationally-oriented digitally-transformed agile pharmaceutical networks in Egypt. This study presented practical and social implications to logistics and supply chain professionals and policy makers on implementing supply chain digital transformation strategies with the aid of creating global partnerships and strategic alliances to reinforce a digitally-driven logistics and supply chain agility within this vital pharmaceutical industry, which will then have an ecofriendly contribution to the society.
Comparative genomic and phenotypic biosafety assessment of plant-associated Klebsiella pneumoniae species complex strains isolated from faba bean root nodules
(Elsevier GmbH, 2026-09-18) Sameh H. Youseif; Fayrouz H. Abd El-Megeed; May S. Soliman; Monerah S.M. Alqahtani; Jawaher I. Alahadeb; Amr Ageez; Akram H. Mohamed; Amani A. El-Kholy
Plant-associated members of the Klebsiella pneumoniae species complex (KpSC) may harbor genomic traits of potential agricultural relevance while also carrying resistance- and virulence-associated determinants of biosafety concern. Here, whole-genome sequencing and comparative genomic analyses were used to characterize nine KpSC strains isolated from Vicia faba root nodules, comprising three Klebsiella quasipneumoniae and six Klebsiella variicola isolates. Genome-based taxonomic analysis identified four sequence types (ST-355, ST-3956, ST-4200, and ST-4574), with phylogenomic analysis indicating that genomic relatedness was more strongly associated with sequence type than isolation source. Comparative analyses revealed lineage-associated differences in resistance- and virulence-associated genomic profiles, while multidrug non-susceptibility was phenotypically observed in K. quasipneumoniae NGB-FR79 and K. variicola NGB-FR73 and NGB-FR75. The genomes also carried genes putatively associated with agriculturally relevant traits, including nitrogen fixation, phosphorus metabolism, iron acquisition, auxin-associated pathways, and adaptation to abiotic stresses. Phenotypic assays further evaluated tolerance to salt and elevated temperature. Collectively, these findings demonstrate that nodule-associated KpSC strains combine putative plant-beneficial genomic traits with resistance- and virulence-associated determinants, emphasizing the need for strain-level genomic and phenotypic biosafety assessment before consideration for agricultural applications.
Pioglitazone protects against thioacetamide-induced liver fibrosis via AMPK-mediated inhibition of the TGF-β/Smad fibrotic cascade
(Springer Science and Business Media Deutschland GmbH, 2026-09-15) Omnia A. Hawary; Walaa Wadie; Yasmin A. M. El-Said; Omnia F. Hassan
Hepatic fibrosis is a progressive liver disorder driven largely by inflammation and oxidative stress. AMP-activated protein kinase (AMPK) plays a pivotal role in regulating hepatic fibrogenesis and represents a promising therapeutic target. Therefore, this study aimed to investigate the hepatoprotective effects of pioglitazone (PIO) and to evaluate whether AMPK activation contributes to its protective actions against thioacetamide (TAA)-induced hepatic injury and fibrosis. Liver injury was induced by intraperitoneal administration of TAA (150 mg/kg, twice weekly) for 9 weeks. During the last 3 weeks, mice received PIO (3 mg/kg/day, orally). Hepatic injury and fibrosis were assessed using biochemical, histopathological, and molecular analyses. PIO treatment significantly attenuated TAA-induced hepatic injury and fibrosis, as demonstrated by improved liver histology, reduced plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels and gamma-glutamyl transferase (GGT) activity, restoration of plasma albumin, and decreased α-smooth muscle actin (α-SMA) expression. These beneficial effects were associated with increased hepatic p-AMPK expression and reduced oxidative stress, evidenced by decreased malondialdehyde (MDA) and nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) levels and restoration of reduced glutathione (GSH) content, as well as suppression of the transforming growth factor-β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) signaling pathway. PIO mitigates TAA-induced hepatic fibrosis, potentially through AMPK activation and subsequent suppression of the TGF-β/Smad signaling pathway, highlighting its potential as a promising antifibrotic agent.
Evaluation the role of quinoa seeds in attenuation the brain cellular senescence and aging induced by D-galactose and γ-radiation in rats: insights into autophagy, telomerase activity, amyloid-β and tau proteins
(Springer Science and Business Media Deutschland GmbH, 2026-09-19) Merehan Alaa-ElDin Mohamed; Mustafa M. M. Elbakry; Nermeen M. Elbakary; Said S. Moselhy; Youssef A. Said
The gradual loss of cognitive function, manifested by impaired learning and spatial memory, is a hallmark of brain senescence during aging. However, effective natural interventions targeting multiple mechanisms involved in aging-related neurodegeneration remain limited. This study assessed the possible protective efficacy of quinoa seed powder (QSP) against D-galactose (D-gal)- and γ-radiation-induced brain senescence in rats. Fifty male albino rats (n = 10/group) were randomly allocated into five experimental groups. Aging was induced by D-gal administration and fractionated whole-body γ-radiation (1.5 Gy/week for four consecutive weeks; total dose 6 Gy). Behavioral performance, oxidative stress biomarkers, telomerase activity, autophagy markers, neurodegenerative proteins, histopathological alterations, antioxidant activity of quinoa ethanolic extract (QEE), and molecular docking were evaluated. QSP significantly (P < 0.05) attenuated oxidative stress, as evidenced by decreased malondialdehyde levels and increased catalase activity and reduced glutathione content. Furthermore, QSP significantly reduced amyloid-β 1–42 (Aβ42) and Tau protein accumulation, increased telomerase activity, and enhanced autophagy-related modulation through upregulation of microtubule-associated protein 1 light chain 3 beta (LC3B) and downregulation of mammalian target of rapamycin (mTOR) expression. In vitro analysis showed that QEE exhibited potent antioxidant activity, with EC50 values of 16.67 and 23.01 mg/mL for TAC and FRAP, respectively, and an IC50 value of 5.91 mg/mL against DPPH radicals. Docking analysis showed that kaempferol exhibited the most favorable binding affinities among the tested quinoa constituents toward mTOR (− 7.579 kcal/mol) and catalase (− 7.286 kcal/mol), with short-timescale molecular dynamics analyses providing additional structural support for the predicted interaction profiles. These findings suggest that QSP exerts multi-target neuroprotective effects through attenuation of oxidative stress and modulation of autophagy-related pathways, supporting its potential as a natural strategy for mitigating aging-associated neurodegenerative changes.
Cuspal displacement, marginal adaptation, and nanoleakage in maxillary premolars restored with a novel auto-cured bulk-fill composite versus a light-cured bulk-fill composite: an in-vitro study
(BioMed Central Ltd, 2026-09-21) Khaled Wagih Al–Saudi; Mohamed Ahmed Basha; Aalaa Mohamed Nabil Amin; Dina Yehia Rehab; Shaymaa Mohamed Nagi; Khaled Beshr; Diaaeldin Farag
Background: STELA is a newly introduced auto-cured bulk-fill composite proposed as an alternative to amalgam. It does not require light activation and provides an unlimited depth of cure, in addition to acceptable esthetic and mechanical properties. Objectives: To evaluate cuspal displacement, marginal adaptation, and nanoleakage in mesio-occluso-distal (MOD) Class II preparations of maxillary premolars restored with an auto-cured bulk-fill composite compared with a light-cured bulk-fill composite. Materials and methods: Sixty maxillary human premolars extracted for orthodontic purposes were randomly assigned to two groups (n = 30) according to the bulk-fill composite used. Standardized MOD Class II preparations were made and restored using either Group 1: STELA Capsule (SDI, Australia) or Group 2: Tetric N-Ceram Bulk Fill (Ivoclar Vivadent, Liechtenstein). Each group was subdivided into three subgroups (n = 10) based on the test performed. In Subgroup 1, cuspal displacement was recorded after post-cavity preparation and at (5 min, 24 h) post-restoration using a digital microscope. The remaining restored specimens underwent thermocycling and mechanical loading. Subsequently, marginal adaptation (Subgroup 2) was examined using scanning electron microscopy. Nanoleakage (Subgroup 3) was evaluated using silver nitrate tracing. Statistical analysis was performed using the independent-samples t-test and Fisher’s exact test (P ≤ 0.05). Results: STELA Capsule demonstrated significantly lower cuspal displacement at both 5 min and 24 h post-restoration compared with Tetric N-Ceram Bulk Fill (P < 0.001). Following thermocycling and mechanical loading, STELA Capsule also exhibited better marginal adaptation (P = 0.033) and reduced nanoleakage (P < 0.001) compared with the Tetric N-Ceram Bulk Fill. Conclusions: The STELA composite with its dedicated primer showed favorable laboratory outcomes compared with Tetric N-Ceram Bulk Fill used with Tetric N-Bond. This restorative protocol can serve as a viable clinical alternative to light-cured bulk-fill composites, particularly for restoring MOD Class II preparations in maxillary premolars. Clinical relevance: The novel auto-cured bulk-fill composite with its dedicated primer demonstrated excellent performance in reinforcing weakened premolars. It exhibited superior results in reducing cuspal displacement, improving marginal adaptation, and minimizing nanoleakage compared to a light-cured bulk-fill composite, indicating its potential for clinical use.