MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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RESEARCH & LANGUAGES CENTERS 18

Recent Submissions

Genomic prediction of phytase potential and stress tolerance in maize-associated plant growth-promoting rhizobacterium Enterobacter cloacae Mz49
(SpringerOpen, 2025-11-29) Mai A. Amer; Samira M. Hamed
The maize rhizobacterium Enterobacter cloacae Mz49 exhibits diverse plant growth-promoting and stress-adaptive traits, indicating strong potential for bioinoculant development. Mz49 was isolated from the Egyptian rhizosphere, and demonstrated in vitro production of indole-3-acetic acid (64.89 µg/mL), antioxidant activity (IC₅₀ = 11.71 µg/mL), and anti-inflammatory properties (IC₅₀ = 63.1 µg/mL). Whole-genome sequencing revealed a 5.34 Mb genome with 5,158 protein-coding genes linked to nutrient acquisition, abiotic stress tolerance, and secondary metabolite biosynthesis. Genes associated with nitrogen fixation (nirBD, ureABCDEFGJ, amtB), phosphate solubilization (pqqIFL, phoA, pstIPN), and phytohormone synthesis (iaaT, ysnE, ipdC, ppdC, amiE) were identified. Genome analysis also revealed phytase-related genes (agp, suhB), which contribute to the release of bioavailable phosphorus, an essential nutrient for maize growth. This genetic potential highlights the strain’s contribution to enhanced plant growth and nutrient-use efficiency, particularly under phosphorus-limited conditions. Additionally, stress-response genes (sodABC, katE, betB, proABCY, dnaJK, cspA) were identified, conferring resistance to oxidative, osmotic, thermal, and cold stresses. The presence of heavy metal resistance genes (arsenic, copper, zinc, nickel) suggests suitability for use in contaminated soils. AntiSMASH analysis identified biosynthetic gene clusters for siderophores, arylpolyenes, and non-ribosomal peptides. GC–MS profiling further detected bioactive compounds, including 2, 3-butanediol, D-pinitol, succinic acid, tyrosol, and azelaic acid, which are associated with plant growth promotion and defense responses. Collectively, these findings highlight Mz49’s potential for sustainable maize cultivation, particularly in phosphorus-limited or stress-prone soils. Future research should prioritize field trials to validate its efficacy and assess potential risks associated with its application.
Amygdalin synergizes with the TNF-α monoclonal antibody infiximab to modulate HSP90 and related necro-infammatory/oxidative stress pathways in a rat model of hepatic I/R
(Springer Science and Business Media Deutschland GmbH, 2025-12-17) Reem A. Mohamed; Mai El‑Sayed Ghoneim; Rasha A. Tawfq; Nermein F. El Sayed
Hepatic ischemia/reperfusion (I/R) injury remains a major limitation in liver surgery and transplantation. Amygdalin, a natural glycoside, is known for its antioxidant, anti-inflammatory, and hepatoprotective properties, but its combination with conventional agents is not studied. Accordingly, this study explores a combinatorial approach using a small dose of amygdalin (5 mg/kg) and low-dose infliximab (1.5 mg/kg), a tumor necrosis factor (TNF)-α inhibitor, as a pre-treatment to alleviate I/R-induced liver injury. It also investigates the unexamined role of heat shock protein (HSP)-90 in the modulation of necro-inflammatory pathways during hepatic ischemia/reperfusion injury. Rats were divided into six groups: sham, I/R, infliximab (1.5 and 3 mg/kg), amygdalin (5 mg/kg), and a combination of infliximab (1.5 mg/kg) with amygdalin. Treatments were administered intraperitoneally for three days before I/R induction. Both monotherapies and the combination significantly reduced hepatic expression of HSP90, TNF-α, and phosphorylated-mixed lineage kinase domain-like protein (p-MLKL), while restoring oxidative balance as evidenced by modulation of nuclear factor erythroid 2-related factor 2 (Nrf2), malondialdehyde (MDA), and superoxide dismutase (SOD). The combination therapy additionally suppressed nuclear factor kappa B (NF-κB) in a synergistic manner and enhanced Nrf2 expression compared to amygdalin monotherapy. Correlation analysis revealed strong associations between markers of necroinflammation and oxidative stress, reinforcing the mechanistic interplay between these pathways. HSP90 emerged in the current study as an intermediate modulator linking necroinflammation to oxidative responses. Importantly, the combined therapy exerted a synergistic effect by effectively modulating HSP90 and associated signaling cascades, underscoring its potential as a superior therapeutic strategy.
Rumex Species: Phytochemistry, Pharmacology and Nutritional Potential for Food and Health Applications
(John Wiley and Sons Ltd, 2025-12-19) Mai Mohamed Gohar; Shahira Mohamed Ezzat; Balakyz Yeskaliyeva; Seham Salaheldin Elhawary; Farid Noshey Kirollos; Aya Khouchlaa; Abdelhakim Bouyahya; Daniela Calina; Javad Sharifi-Rad; William N. Setzer; Miquel Martorell
The genus Rumex (Polygonaceae), comprising about 193 species, is widely distributed across temperate and subtropical regions of Europe, Asia, Africa, and North America, and has long been used in traditional medicine worldwide. These species are rich in diverse phytochemicals, including anthraquinones, flavonoids, tannins, naphthalenes, and stilbenes, which contribute to a broad range of biological activities. This review provides an updated synthesis of current knowledge on the taxonomy, phytochemistry, and pharmacological properties of Rumex species. Particular attention is given to R. dentatus, R. vesicarius and R. crispus, which exhibit antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, antidiabetic, and anticancer effects in both in vitro and in vivo studies. Clinical and toxicological aspects, including oxalate accumulation and anthraquinone-associated adverse effects, are also discussed. Major research limitations include the lack of standardized extracts, insufficient clinical evidence, and poor bioavailability of key compounds. Enhancing bioavailability is vital because many bioactive compounds in Rumex are poorly absorbed and rapidly metabolized, which restricts their therapeutic potential. Environmental factors and phenological stages influencing phytochemical expression are highlighted as additional underexplored determinants of bioactivity. By integrating ethnopharmacological knowledge with experimental data, this review identifies future research priorities, including the optimization of formulation strategies, pharmacokinetic evaluation, and clinical validation. Collectively, these efforts may support the development of safe and effective Rumex-based nutraceuticals and therapeutic products.
Corrigendum to Socket Preservation Using PlateletRich Fibrin and Free Gingival Grafts
(Elsevier Inc., 2025-06) Haya Hesham Abdel-Latif Afif; Shaimaa Saieed Nasr; Munerah Saleh BinShabaib; Shatha Subhi Alharthi; Mona Shoeib
The funding section should be: ‘The authors would like to thank Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2025R63), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia for funding this project.’ Instead of: ‘The authors would like to thank Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2024R63), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia, for supporting this project.
Role of microRNA-183 based theranostics through targeting TPM1 in bladder cancer
(Springer Science and Business Media Deutschland GmbH, 2025-11-13) Samah Mamdouh; Tarek Aboushousha; Eman Hemida; Rady E. El-Araby; Khaled Elesaily; Gehan Hammad; Mona Magdy
Background: MicroRNA-183 (miR-183-5p), a noncoding RNA, is upregulated in bladder carcinoma (BC). Although it has been implicated in oncogenesis, its precise regulatory effects and biological functions remain unclear. Tropomyosin-1 (TPM1) was shown to be downregulated in solid tumors and was previously identified as a novel tumor suppressor gene. Objectives: Our study focuses on the prognostic, diagnostic, and therapeutic potential of miR-183-5p in bladder carcinoma and assess TPM1 gene targets and their modulatory functions. Methods: Urine cytology, cystectomy and transurethral resection (TUR) biopsies from 148 BC patients were collected. TPM1 protein and miR-183-5p expressions were assessed through immunohistochemistry (IHC) and real-time PCR respectively. In vitro assay investigated the effect of miR-183-5p on TPM1mRNA in bladder carcinoma cell lines, then confirmed by comparing miR-183-5p mimics in non-cancerous and urothelial carcinoma cell lines. Concomitant TPM1 gene expression was examined, and the theranostic miR-183-5p potential was evaluated. Results: Upregulation of miR-183-5p expression in BC tissue biopsies and urine cytologies was noted, contrasting the downregulation of TPM1 protein expression in the high-grade, high-stage, lymph node metastatic BC tissues (in comparison to non-cancerous, low-grade, low-stage non-lymph node metastasizing BCs). Moreover, the miR-183-5p oncogenic influence was responsive in targeting TPM1 gene at 3′UTR region, and miR‑183‑5p.1 restricted TPM1 expression in T24 cells. Conclusion: This study provides the first illustration of the miR-183-5p–TPM1 axis in bladder carcinoma, supporting the theranostic role of miR-183-5p as an onco-miR in BC progression, diagnosis, and prognostication. Key points: Upregulation of miR-183-5p: The study demonstrates significant upregulation of miR-183-5p in bladder carcinoma tissues and urine, especially in high-grade and metastatic cases, suggesting its potential as a non-invasive biomarker for BC diagnosis.Upregulation of miR-183-5p: The study demonstrates significant upregulation of miR-183-5p in bladder carcinoma tissues and urine, especially in high-grade and metastatic cases, suggesting its potential as a non-invasive biomarker for BC diagnosis. Urine-based Detection: miR-183-5p was effectively detected in urine samples, showing potential for early detection of BC through a non-invasive method, improving upon current diagnostic tools like cytology and cystoscopy. Tumor Suppressor Role of TPM1: The study confirms that TPM1 is significantly downregulated in BC, particularly in high-grade, muscle-invasive, and metastatic bladder cancers. Inverse Relationship: There is an inverse correlation between miR-183-5p expression and TPM1 levels, with miR-183-5p directly targeting TPM1 and suppressing its expression, contributing to cancer progression. Theranostic Role of miR-183-5p: This study positions miR-183-5p not just as a diagnostic marker but also as a potential therapeutic target (theranostic) that can be manipulated to inhibit bladder cancer progression. miR-183-5p and Disease Severity: The expression of miR-183-5p correlates with tumor grade, stage, and metastasis, making it a reliable marker for prognostication. High miR-183-5p levels are associated with worse clinical outcomes.