MSA Repository "MSAR"
MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.
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Recent Submissions
Metabolic Shift and Hyperosmolarity Underlie Age-Related Macular Degeneration
(MDPI, 2024-09-20) Laurent Schwartz; Jules Schwartz; Marc Henry; Ashraf Bakkar
Age-related macular degeneration (AMD) is both a poorly understood and devastating
disease. Here, we analyze the physico-chemical forces at stake, including osmolarity, redox shift,
and pressure due to inflammation. Hyperosmolarity plays a key role in diseases of the anterior
segment of the eye such as glaucoma, cataracts or dry eyes, and corneal ulceration. However,
its role in macular degeneration has been largely overlooked. Hyperosmolarity is responsible for
metabolic shifts such as aerobic glycolysis which increases lactate secretion by Muller cells. Increased
osmolarity will also cause neoangiogenesis and cell death. Because of its unique energetic demands,
the macula is very sensitive to metabolic shifts. As a proof of concept, subretinal injection of drugs
increasing hyperosmolarity such as polyethylene glycol causes neoangiogenesis and drusen-like
structures in rodents. The link between AMD and hyperosmolarity is reinforced by the fact that
treatments aiming to restore mitochondrial activity, such as lipoic acid and/or methylene blue, have
been experimentally shown to be effective. We suggest that metabolic shift, inflammation, and
hyperosmolarity are hallmarks in the pathogenesis and treatment of AMD.
Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses
(BMC Pediatrics, 2024) Hanan Mina Fouad; Amal Ahmed Mohamed; Nashwa Adel; Mohamed Abdulhay; Iman Khalifa; Randa Ibrahim; Naglaa Elsalway; Ghada Maher Thabet; Karima Nasraldin; Ingy Maher El-Hefny; Marwa S. Abd Elraouf; Dalia Ghareeb
Objectives to estimate insulin-like growth factor-1 (IGF-1) levels in apparently healthy infants and prepubertal
children and compare results among different nutritional statuses.
Methods Our cross-sectional work is a sub-study of a screening project for anemia and nutritional status. We
included 252 apparently healthy infants and children with a mean age of 3.7 ± 1.3 years (1.1–6.6), with equal gender
distribution. Data retrieved included breastfeeding and anthropometric measures. We tested the stored blood
samples for IGF-1 levels. The sample size was reached when all kits were consumed.
Results abnormal anthropometric measures were detected in 32.9%, either a single or multiple, and 86.5% were
breastfed. Girls had significantly higher serum IGF-1 levels than boys (P: <0.001), which was noticeable in girls with
abnormal nutritional status detected with anthropometry. Breastfeeding showed no significant association with IGF-1
levels. No significant difference was observed between IGF-1 levels between children with normal versus those with
abnormal growth measures. Children with overweight or obesity had significantly lower IGF-1 than children with
other body mass index (BMI) categories. Serum IGF-1 levels correlated positively with arm muscle area Z scores in
infants and toddlers and weight and BMI Z scores in children between three and four. Also, IGF-1 correlated positively
with the triceps skinfold Z score and arm muscle area Z score between four and five.
Conclusions Among studied infants and prepubertal children, serum IGF-1 was significantly higher in girls than boys
and was considerably lower in children with overweight or obesity. Breastfeeding showed no association with IGF-1
levels.
The MiR-200c/FOXP3 Network: A Promising Biomarker for Predicting Trastuzumab Response in HER2-Positive Breast Cancer
(Sage: Technology in Cancer Research & Treatment, 2023-10) Mohamed S. Othman,; Mohamed Tharwat Elabbasy,; Ahmed M. Aref,; Aya A. Altaleb; Marwa Hamdy Mohammed,; Doaa Atef Mohamed Soliman,; Nashwa El-Khazragy,
Purpose: Resistance to Trastuzumab is a significant challenge in the management of HER2-positive Metastatic Breast cancer
(HER2-MBC), and a better understanding of the molecular causes of resistance is required to develop more effective treatment
plans. While elevated plasma levels of miR-200 and FOXP3 have been linked to breast cancer progression and treatment
response, no clinical studies have confirmed these results. Methods: The study involved 40 patients with HER2-positive metastatic
breast cancer (HER2-MBC). The expression levels of miR-200c-3p and the FOXP3 gene were assessed in plasma samples at
two time points: baseline (BL) and after the consent completion of one cycle of Trastuzumab, utilizing quantitative polymerase
chain reaction (qPCR). Clinical response to Trastuzumab was evaluated 12 months post-therapy and correlated with the time to
progression (TTP) through Kaplan-Meier analysis. Results: Low plasma expression level of miR-200c-3p was detected before
therapy in HER2-MBC, compared to healthy controls, and decreased dramatically in the follow-up sample at disease progression,
while increased after one cycle of Trastuzumab therapy in patients who were sensitive to Trastuzumab. At baseline, a low expression
level of miR-200c was significantly associated with overexpression of FOXP3, poor prognosis, and shorter time to progression.
Conclusions: The findings suggest that miR-200c-3p may be a promising biomarker for predicting the response to
Trastuzumab in HER2-MBC patients.
β‑glucan nanoparticles alleviate acute asthma by suppressing ferroptosis and DNA damage in mice
(Apoptosis : an international journal on programmed cell death
, 2024-09-21) Bassam W. Ebeed; Islam Ahmed Abdelmawgood; Mohamed A. Kotb; Noha A. Mahana; Ayman Saber Mohamed; Marwa A. Ramadan; Abeer Mahmoud Badr; Manar Nasr; Osama Mohsen Qurani; Reem Mohamed Hamdy; Nada Yasser Abd El‑Hakiem; Mariam Khaled Fahim; Mariam Morris Fekry; Jehane I. Eid
Asthma is a severe respiratory disease marked by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG), a
polysaccharide constituent of fungal cellular structures, exhibits potent immunomodulatory activities. The investigational
focus was on the anti-asthmatic and anti-ferroptotic properties of beta-glucan nanoparticles (BG-NPs) in a murine model of
allergic asthma induced by ovalbumin (OVA). BG was extracted from Chaga mushrooms (Inonotus obliquus), and its BGNPs
were characterized utilizing techniques including FT-IR, UV visible spectroscopy, zeta potential analysis, DLS, XRD,
and TEM. The Balb/C mice were allocated into five groups: control, untreated asthmatic, dexamethasone (Dexa)-treated
(1 mg/kg), BG-treated (100 mg/kg), BG-NPs-treated (45 mg/kg), and BG-treated (100 mg/kg). Treatment with BG-NPs
markedly diminished the entry of inflammatory cells into the respiratory passage, serum IgE concentrations, DNA damage,
and markers of oxidative stress through the reduction of malonaldehyde (MDA) levels and enhancing the levels of reduced
glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). Furthermore, BG-NPs
reduced iron deposition and promoted the transcriptional activity of the GPx4 gene in pulmonary cells, attenuating ferroptosis.
The results demonstrated that BG-NPs reduced asthma by inhibiting oxidative stress, inflammation, DNA damage, and
ferroptosis. Our results suggest that BG-NPs could be used as potential treatments for allergic asthma.
Eco-friendly production of biodiesel from Carthamus tinctorius L. seeds using bismuth oxide nanocatalysts derived from Cannabis sativa L. Leaf extract
(Institution of Chemical Engineers, 2024-08) Abbasi, Tehreem Usman; Ahmad, Mushtaq; Alsahli, Abdulaziz Abdullah; Asma, Maliha; b, Rozina; Mussagy, Cassamo Ussemane; Abdellatief, Tamer M.M; Pastore, Carlo; Mustafa, Ahmad
Global challenges in environmental protection, social welfare, and economic growth necessitate increased energy production and related services. Biofuel production from waste biomass presents a promising solution, given its widespread availability. This study focuses on converting highly potent Carthamus tinctorius L. seed oil (51 % w/w) into sustainable biofuel using a novel, highly reactive, recyclable, and eco-friendly bismuth oxide (Bi2O3) nano-catalyst derived from Cannabis sativa L. leaf extract. The physio-chemical properties of the synthesized biodiesel were analyzed using Gas Chromatography/Mass Spectroscopy (GC-MS), Nuclear Magnetic Resonance (NMR), and Fourier-Transform Infrared Spectroscopy (FTIR). Additionally, the green Bi2O3 nanoparticles were characterized through Scanning Electron Microscopy (SEM), Energy Diffraction X-Ray (EDX), and X-Ray Diffraction (XRD). Optimal conditions for biodiesel production were determined using Response Surface Methodology (RSM) in combination with Central Composite Design (CCD), focusing on molar ratio, catalyst loading, and reaction duration. The highest output (94 %) of C. tinctorius-derived biodiesel (CTBD) was achieved under the following conditions: a temperature (75 °C) for time duration (100 min), a methanol to oil ratio (6:1), and a catalyst loading (0.69 wt%). The resulting biodiesel met international standards, with a sulphur content of 0.00097 wt%, and an acid value of (0.34 mg KOH/g). This study demonstrates that converting C. tinctorius waste seed oil into clean bioenergy is an effective waste management strategy that minimizes environmental impact.