MSA Repository "MSAR"
MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.
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Recent Submissions
Sodium hypochlorite accident—complications, management and potential prevention: a report of three cases
(AME Publishing Company, 2025-01-07) Ayat Gamal-AbdelNaser; Alaa Elnaggar; Menna Mekawy; Gerges Boshra; Neveen Ghareeb
Background: Sodium hypochlorite (NaOCl) is a powerful irrigant for endodontic treatment. But, when
extruded beyond the root apex, it becomes cytotoxic to patient’s tissues causing NaOCl accidents. The
complications include ulceration to the soft tissues and irritation of nerves causing long term symptoms.
Being under- or poorly-reported, this report presents cases for complications of NaOCl accident. Complying
to the suggested criteria for well-reported NaOCl accidents, the report aims to help—with others—in
clarifying the full picture of the situation Accordingly, a standardized plan for its prevention and management
would be possible.
Case Description: The current report presents three cases of females with post-NaOCl accident
symptoms after performing endodontic treatment for a maxillary anterior tooth. The three patients presented
after days of the accident with a deep ulcer in the buccal vestibule related to the treated tooth. Each case
suffered from a further different complication in the form of: paresthesia of the infraorbital nerve in the first
case, transient partial facial palsy beside the sensory deficit in the second case, and necrosis and deepening of
the oral ulcer in the third patient. The cases received roughly the same treatment of oral ulcer debridement
and dressing application, followed by antibiotic and analgesic prescription. Vitamin B12 supplements were
prescribed in case of neural deficits and warm fomentations were advised in case of extraoral swelling. In
all cases, post-operative instructions included strict hygiene of the intraoral lesion and daily repeated saline
irrigation. The oral ulcers healed within 8 weeks while the neurological deficits were improving by the fourth
month.
Conclusions: This report emphasizes on the importance of using packs, complying to strict hygiene and
prescribing vitamin B12 supplements in improving and accelerating healing of prolonged post-NaOCl
accident symptoms. The report may also help anticipate the prognosis of NaOCl accidents with different
severities and presentations. Showing the severity of the complications, the report further highlights on the
importance of the accident’s prevention, so that all these sequelae would be avoided.
Survival beneft of cancer‑directed surgery and the role of adjuvant therapy in malignant major salivary gland cancers: a propensity score matched retrospective analysis
(W.B. Saundersw, 2025-01-09) Ahmed Elkoumi; Omar Elkoumi; Mohamed Hamouda Elkasaby; Huzifa Khitiy; Mariam Khaled Elbairy; Ahmed Tawfk; Omar K. Habib; Abeer Shaalan
Background The primary objective of this study was to assess the beneft of cancer-directed surgery (CDS) on both overall
survival (OS) and cancer-specifc survival (CSS) of patients with malignant major salivary gland cancers (MMSGCs). The
secondary objective was to explore the benefts of adjuvant therapy on the survival outcomes of these patients.
Methods Patients diagnosed with MMSGC were extracted from the SEER database and subsequently categorized into two
cohorts: CDS and non-CDS. Propensity score matching (PSM) was used to mitigate confounding variables. The survival
beneft associated with CDS was evaluated using Kaplan–Meier analysis, log-rank tests, and Cox proportional hazard models.
Furthermore, the impact of adjuvant radiotherapy and chemotherapy was explored within the CDS subgroup.
Results A total of 7,029 patients with MMSGC were included. PSM was performed and resulted in a matched cohort between
both groups, including 595 patients in each group. Multivariable Cox proportional hazard indicated that patients who received
CDS had better OS (HR: 0.45, 95% CI [0.39 to 0.52], P<0.001) and CSS (HR: 0.46, 95% CI [0.40 to 0.52], P<0.001).
The 5- and 10-year OS for the CDS group was 42% (95% CI, 38 −46%), and 25% (95% CI, 21 −29%) consecutively, while
the 5- and 10-year OS for the non-CDS group was 20% (95% CI, 17 −24%), and 12% (95% CI, 9.7 −16%) consecutively.
Moreover, patients with younger age, localized tumors, and lower TNM stage could beneft more from CDS. Radiotherapy
as adjuvant therapy was found to be benefcial (HR: 0.69, 95% CI [0.55–0.85], p<0.001), while chemotherapy could not
signifcantly beneft these patients.
Conclusion CDS improved the OS and CSS survival in MMSGC patients. Specifc patient subgroups seemed to have a
superior beneft from CDS. Adjuvant radiotherapy could help enhance the survival outcomes of these patients while chemotherapy could not.
Ezetimibe Loaded Nanostructured Lipid Carriers Tablets: Response Surface Methodology, In-vitro Characterization, and Pharmacokinetics Study in Rats
(Springer New York, 2025-01-09) Dalia Elkhayat; Nevine S. Abdelmalak; Reham Amer; Heba H. Awad
Purpose The present study aims to overcome the poor oral bioavailability of ezetimibe (EZ), a selective Biopharmaceutics
Classification System (BCS) Class II cholesterol absorption inhibitor drug. EZ-loaded nanostructured lipid carriers (EZNLCs) were dried by lyophilization and incorporated in a convenient oral solid dosage form to enhance its dissolution, and
absorption and increase patient compliance. Response surface methodology (RSM) was employed to systematically optimize formulation variables, improving the efficiency of disintegration and drug release characteristics.
Methods RSM was adopted to study the effects of (A) increasing the amount of the super-disintegrant, crosscarmelose
sodium, (CCS), and (B) varying the ratio between the used drying excipients Avicel and mannitol (A: M) on the disintegration time (R1), and the percentage drug released after 24 h (R2). Thirteen EZ-NLCs tablets were prepared and subjected to
pre-compression and post-compression evaluation. Furthermore, a bioequivalence study was conducted by administering
EZ-NLCs and ezetrol® tablets to Sprague Dawley male rats.
Results The optimized EZ-NLCs tablet (prepared with the ratio of Avicel: mannitol (7.5:0) using 30 mg CCS), revealed
a disintegration time of 3.85±0.03 min, and 98±3.09% of the drug were released at the end of the 24 h. EZ-NLCs tablet
displayed a maximum concentration (Cmax) of 3.57±0.27 ng/mL and an area under the curve (AUC0−24) of 22.44±2.68
ng.hr/mL, while those of ezetrol® were 2.79±0.15 ng/mL and 15.36±0.86 ng.hr/mL, respectively.
Conclusion The assessed relative bioavailability demonstrated the superiority of EZ-NLCs tablet over ezetrol® with 1.5 fold
improvement which proves that EZ-NLCs tablet could be a good candidate to enhance the oral bioavailability of EZ.
Unraveling the Link between Corruption and Stock Market Performance in the MENA Region: Insights from Panel ARDL Model. (Empirical study)
(Ain shams University, 2024-06-26) Sarah Sobhy Mohamed Hassan; Yasser Tawfik Halim Tawfik; Mohamed Samy Tawfik El Deeb; Esmat Mostafa Mohamed Kamel
Purpose: The primary purpose of this study undertaking is to
investigate the relationship between corruption and financial
market indicators across diverse groups of countries. Our goal is
to scrutinize the potential effects of corruption on trading
volumes, market capitalization, and trading ratios, while
considering the influence of GDP and inflation. Through a
thorough examination of both nations characterized by clean
governance and those plagued by corruption, our research seeks
to contribute to the understanding of how corruption impacts
financial markets.
Design/Methodology/Approach:
Diverging from the
predominant trend in previous studies that treated the MENA
region as a collective dataset, our methodology involves
classifying MENA countries into two distinct categories based on
their corruption levels. We employ a quantitative approach using
panel data that spans a diverse array of nations. Our analysis
utilizes various econometric models, including random-effects
and fixed-effects models (ARDL), to scrutinize the relevant
relationships. To account for potential influences on observed
outcomes, we integrate control variables, specifically inflation
and GDP, into the models.
Findings: Our findings demonstrate significant variations in the
impact of corruption on financial market indicators across
different country groups. Corruption exhibits negative
associations with market capitalization, trading volumes, and
positive association with trading ratios. Additionally, the control
variables GDP and inflation contribute distinctively to these
relationships. The results also highlight the significance of
corruption as a determinant of financial market performance in
both corrupt countries and clean countries.
Originality/Value: This study adds significant value to the
existing knowledge base by conducting a thorough investigation
into the relationship between corruption and financial market
indicators. Through the integration of diverse econometric
methods and considering the moderating effects of GDP and
inflation, our research offers a comprehensive insight into the consequences of corruption in countries characterized by both
integrity and corruption. Embracing this inclusive approach
provides policymakers, investors, and researchers with
substantial insights into the intricate dynamics between
corruption and the functioning of financial markets.
In conclusion, this research enhances the understanding of
corruption's implications for financial markets, emphasizing the
significance of context and control variables. By shedding light
on the nuanced interactions, this study contributes to a more
comprehensive comprehension of corruption's multifaceted
impact on financial market indicators.
THE EFFECT OF POLY (N-ISOPROPYLACRYLAMIDE) BASED MICROGEL APPLICATION ON THE MICROTENSILE BOND STRENGTH TO DENTIN: AN IN VITRO STUDY
(EGYPTIAN DENTAL JOURNAL, 2024-07-10) Mona Mohamed Fadel; Dina Mohamed Wahied; Reham Mohsen; Aliaa Mohamed Abdel Rahman El Wakeel
Objective: This study was carried out to determine the effect of polyNIPAM microgel
particles on the microtensile bond strength (µTBS) of universal adhesive to dentin before and after
thermocycling.
Materials and methods: Superficial dentin discs were prepared from young human upper premolars. Specimens were divided into three groups GI: All-Bond Universal adhesive was applied
directly to etched dentin. G2: 2% polyNIPAM microgel was added to the adhesive before being
applied to etched dentin. G3: 2% polyNIPAM microgel was applied on etched dentin before application of the adhesive. In all groups, after light activation of the adhesive, resin composite (Filtek
Z350 XT), was applied incrementally on the treated dentin specimens. A total of 120 beams were
prepared. Half of these beams were subjected to 5000 cycles of 5°C to 55°C using a PCR thermocycler. Microtensile bond strength testing was performed on all specimens. The fractured dentin side
of all specimens was inspected using a scanning electron microscope (SEM) at 200X magnification.
Three sticks from each group were gold sputter coated and examined with SEM at 2000X.
Results: The statistical analysis showed that before thermocycling, there was a statistically
significant difference in the mean µTBS values of all the tested groups p <0.001. G1T0 showed the
highest statistically significant mean µTBS values. After thermocycling, G1T1 showed the lowest
statistically significant mean µTBS values p= 0.001. Failure mode analysis and SEM analysis
confirmed and explained the µTBS results.
Conclusion: The addition of polyNIPAM microgel to etched dentin preserved the bond
durability, particularly after thermocycling.