MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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MSA Journals 140
A Full content for MSA university Faculties Journals
MSA Theses 5
A digital collection of MSA University postgraduate theses, including PhD and Master’s theses, organized by academic degree and faculty.
MSA University Academic Graduation Projects 1153
A Full content for msa university Distinguished Graduation Projects Yearbook
MSA University Academic Research 3768
MSA University Campus 2
Images for MSA University " sites - building - landscape "

Recent Submissions

Gamma Radiation–Induced Synthesis of Pectin/Arabic Gum‑Based Nanocomposite Hydrogels for Enhanced Water Remediation
(Springer Nature, 2026-07-11) Asmaa Sayed; D. M. Aboelkhir; Razan Mohamed; Ayman Amin; Ghada A. Mahmoud
Industrial dye contamination represents a major environmental concern, necessitating efficient and sustainable remediation strategies. In this study, a CuO@pectin/Arabic gum-g-diethylaminoethyl methacrylate (CuO@pectin/Arabic gum-g-DEAEMA) nanocomposite hydrogel was developed via gamma irradiation–induced copolymerization, providing a clean and initiator-free synthesis route. Successful incorporation of CuO nanoparticles was confirmed by DLS, EDX, and XRD analyses, while TGA demonstrated enhanced thermal stability. SEM observations revealed a rough and wrinkled surface morphology favorable for dye adsorption. BET analysis further showed that CuO incorporation increased the surface area from 14.05 to 28.22 m2 g⁻1 and the total pore volume from 0.08685 to 0.2201 cm3 g⁻1, confirming improved porosity and accessibility of adsorption sites. Adsorption studies showed that methylene blue (MB) removal follows a pseudo-second-order kinetic model, indicating chemisorption, while the Freundlich isotherm suggests heterogeneous multilayer adsorption. The CuO-containing hydrogel exhibited significantly improved adsorption performance compared with the pristine system. In addition, the nanocomposite demonstrated antibacterial activity against Gram-positive bacteria, indicating potential resistance to biofouling. The developed hydrogel combines green synthesis, enhanced porosity, improved adsorption efficiency, and multifunctional performance, making it a promising candidate for sustainable wastewater treatment applications.
TPGS-decorated lipopolymersomes encapsulating piperine for myocardial infarction: response surface optimization, in vivo Cardioprotection, and physiologically based pharmacokinetic modeling
(Taylor and Francis Ltd., 2026-07-14) Marwa H. S. Dawoud; Heba T. Elbalkiny; Mai A. Zaafan; Nabila M. Sweed
Piperine, derived from black pepper, exhibits powerful cardioprotective activity. However, its poor solubility limits its clinical translation for myocardial infarction (MI) management. This study aims to develop piperine-loaded lipopolymersomes for MI, to assess systemic and cardiac exposure. Lipopolymersomes were prepared using emulsification-solvent evaporation method, followed by surface coating with TPGS. The lipid-to-polymer ratio and nanoparticles-to-drug ratio were optimised for ideal particle size, zeta potential, and encapsulation efficiency. Oral pharmacokinetics and physiologically based pharmacokinetic (PBPK) modelling were conducted to evaluate bioavailability enhancement and predict cardiac exposure. Cardioprotective efficacy was assessed using an isoprenaline-induced mouse model of MI. TPGS-decorated lipoloymerosomes (O1-TPGS) exhibited a size of 188.56 ± 8.33 nm, a zeta potential of −19.67 ± 2.81 mV, and 98.67 ± 4.80%. entrapment efficiency. The formulation provided sustained piperine release over 72 h. Piperine oral systemic exposure was increased by 1.5-fold. PBPK simulation predicted a three-fold increase in cardiac concentration and area under the curve for O1-TPGS versus unformulated piperine. O1-TPGS normalised heart rate, reduced creatinine kinase-MB and troponin-I, and suppressed NLRP3, mTOR, NF-κB, and IL-6 than standard piperine, with superior preservation of myocardial architecture. TPGS-modified lipopolymersomes markedly enhanced the systemic and cardiac bioavailability of piperine, translating this pharmacokinetic improvement into superior cardioprotective effects in isoprenaline-induced MI.
From Global Competitiveness to Composite Index of Systemic Competitiveness (CISC): Developing the CISC Through a Comparative Analysis of Saudi Arabia and Egypt
(SAGE Publications Inc., 2026-07-19) Ahmed Maree; Ramy Abdelhamid Aldallal; Yasser Tawfik
This study introduces the Composite Index of Systemic Competitiveness (CISC), a new framework to quantify national competitive potential by the examination of three interdependent pillars: governance efficiency, economic mass, and competitiveness drag. A focus on Saudi Arabia and Egypt from 2020 to 2023, this research examines how institutional performance, economic diversification strategies, and structural constraints affect development pathways in alignment with the United Nations Sustainable Development Goals (SDGs), especially SDG 8 (Decent Work and Economic Growth) and SDG 10 (Reduced Inequalities). Cross-national, quantitative case study is the research design. The CISC combines internationally aggregated measurements of indicators from only 2020 to 2023 for Egypt and KSA from institutions such as the World Bank, IMF, and Transparency International, for example, economic resilience variables, governance norms, non-oil GDP growth, and measures to mitigate inequality. Sensitivity tests ensure index reliability through tests of robustness. As a limitation for the study, data used in the study is a 4 years data for both Egypt and KSA from 2020 to 2023. Saudi Arabia exhibits remarkable CISC developments, fueled by governance reform and economy diversification in line with Vision 2030, speeding up to SDG 8. Conversely, Egypt is hindered by budget constraints, institutional fragility, and persisting inequalities, restraining SDG 10 ambitions. The implications show that balance synergism among macroeconomic policy, institutional responsibility, and distributive policies are essential to unlock sustainable development. The CISC presents a revolutionary way of measuring systemic competitiveness in the form of direct ratio correlation with SDG standards. The instrument provides policymakers with a diagnostic tool that can help them determine reform priorities to reconcile economic growth and social cohesiveness and long-term sustainability. The CISC facilitates the realignment of efforts with systemic competitiveness drivers, allowing evidence-based policy-making for maximizing national development results and global economic positioning. Governments and institutions can utilize this framework to navigate structural risks while following inclusive growth agendas.
Adaptive Shooting Analysis of Magnetized Micropolar Flow in Transpiration-Controlled Riga Channels with Radiative and Cross-Diffusion Effects
(Springer Nature, 2026-07-05) Sameh E. Ahmed; Anas A. M. Arafa; Sameh A. Hussein; M. Khalil
Electromagnetically controlled transport in microstructured fluids is of considerable interest in advanced thermofluidic and microfluidic technologies, particularly when heat and mass transfer are strongly coupled. This study investigates steady micropolar fluid flow and coupled thermo-solutal transport in a transpiration-controlled channel driven by an upper Riga plate. The mathematical model accounts for non-uniform Riga-induced Lorentz forcing, thermal radiation, Joule dissipation, and Soret–Dufour cross-diffusion effects, leading to a highly nonlinear system of coupled boundary-value equations. The novelty of the work lies in examining the combined influence of these mechanisms within a confined micropolar channel configuration, which has received limited attention in the existing literature. The governing equations are transformed into a dimensionless form and solved using a fourth-order Hybrid Block Runge–Kutta shooting scheme with analytical initialization. The results demonstrate that micropolar material parameters suppress the velocity, microrotation, and concentration fields while enhancing the temperature distribution. Stronger electromagnetic forcing generated by the Riga plate and larger modified Hartmann effects significantly attenuate the flow and microrotation characteristics. Moreover, Dufour and Soret cross-diffusion mechanisms substantially modify thermal and concentration transport, whereas increasing thermal and mass Peclet numbers enhance local heat and mass transfer rates. These findings provide new insight into the control of coupled momentum, thermal, and species transport in electromagnetically actuated micropolar channel flows and offer useful guidance for the design of advanced thermal-management and microfluidic systems.
Comparative Bioassay-Guided Fractionation of Citrus Species: Phytochemical Characterization and Nanoformulation of a Polyphenol-Rich Leaf Fraction from Citrus aurantifolia for Skin Anti-Aging Applications
(Multidisciplinary Digital Publishing Institute (MDPI), 2026-07-01) Noha Swilam; Khaled A. Nematallah; Amgad Albohy; Noha M. Badawi; Sameh S. Gad; Maha M. Shouman; Saeed S. Al-Ghamdi; Abdullah R. Alzahrani; Nahla Ayoub
Background: Skin aging is driven by oxidative stress and ultraviolet (UV) exposure, leading to extracellular matrix degradation and loss of skin elasticity. This study aimed to identify the most biologically active Citrus species using a bioassay-guided approach and evaluate its potential for dermal applications. Methods: Hydroalcohol extracts and ethyl acetate fractions of Citrus sinensis, Citrus aurantifolia, and Citrus reticulata leaves were screened for antioxidant, enzyme-inhibitory, and polyphenol content. The most active fraction was characterized by UPLC-PDA and LC–MS/MS, formulated into Span-based nanovesicles, and evaluated for physicochemical properties and drug release. Biological activity was assessed using an in vitro scratch wound-healing assay on human dermal fibroblasts and a UVA-induced photoaging mouse model, supported by molecular dynamics simulations. Results: The ethyl acetate fraction of C. aurantifolia (CAE) exhibited the highest biological activity among the tested samples. This fraction showed potent antioxidant activity (DPPH IC50 = 3.53 ± 0.05 µg/mL), marked inhibition of elastase (91.3%), collagenase (92.0%), and tyrosinase (80.2%), and a high total flavonoid content (110.49 mg rutin equivalents/g). Phytochemical profiling of CAE tentatively identified fourteen compounds, predominantly flavonoids, with hesperidin (30.4 mg/g) as a major constituent. The optimized nanovesicles (184 ± 0.9 nm, PDI 0.10, EE% 75.0%) enabled sustained hesperidin release. CAE and CAEnp enhanced fibroblast migration and accelerated wound closure at 24 h (p < 0.05). In vivo, CAEnp improved UVA-induced histopathological alterations and modulated oxidative stress-related markers by reducing p62/SQSTM1 by 28.7%, Keap1 expression to 21% compared with the CAE-treated group, and enhancing Nrf2, ARE, and NQO1 expression by 54.1%, 28.3%, and 57%, respectively. Molecular dynamics simulations supported stable hesperidin binding to elastase and suggested possible modulation of collagenase flexibility. Conclusions: The polyphenol-rich leaf fraction from C. aurantifolia, identified through comparative bioassay-guided fractionation, demonstrated antioxidant, enzyme-inhibitory, wound-healing, and photoprotective effects, particularly after nanoformulation. These findings support its potential for further development as a natural topical anti-aging candidate.