MSA Repository "MSAR"
MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.
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Amaranthus spinosus Linn. Extract as an Innovative Strategy to Regulate Biomarkers for Ovarian Hyperthecosis via Circular RNA (hsa-circ-0001577): Evidence From Biochemical, Metabolomics, Histological, and Phytochemical Profiling
(John Wiley and Sons Ltd, 2025-05-08) Naglaa M. Ammar; Mai O. Kadry; Asmaa S. Abd Elkarim; Reham S. Ibrahim; Ibrahim E. Sallam; Abd El-Nasser G. El Gendy; Sherif M. Afifi; Tuba Esatbeyoglu; Mohamed A. Farag; Abdelsamed I. Elshamy
Amaranthus species, including A. spinosus Linn, are well-known vegetables whose leaves, shoots, fragile stems, and grains
are commonly utilized as herbs in soups or sauces, aside from traditional uses to treat a wide range of illnesses. Ovarian
hyperthecosis is a common syndrome associated with metabolomics and endocrinology that lowers female fertility. The
investigation of novel biomarkers and targeted therapies for the detection and treatment of ovarian hyperthecosis is of interest. Types of noncoding RNAs known as circular RNAs (circRNAs) have covalently closed cyclic structures, are widely
distributed, and exhibit expression patterns that are particular to different stages of development. Ovarian hyperthecosis
was induced in rats via dehydroepiandrosterone (DHEA) followed by 1 month of treatment with 50 and 100 mg/kg of the
A. spinosus EtOH extract. Further, oxidative stress biomarkers including GSH and MDA were investigated in addition to
hormonal biomarkers, such as Luteinizing hormone and testosterone hormone, a metabolomics approach modeled using
orthogonal partial least squares discriminant analysis (OPLS-DA), and circRNA (hsa-circ-0001577). Furthermore, UHPLCESI-Orbitrap-MS analysis was used for metabolites profiling to identify active agents in the plant extract. Results revealed
a significant improvement in these biomarkers in the DHEA group treated with A. spinosus, especially at high doses, and
further confirmed via histopathological assays. Multivariate data analyses of serum metabolome indicated significant variations in serum profiles among normal, disease, and treated groups. Variable importance in the projection (VIP) values
guided the selection of differentiated metabolites, revealing significant changes in metabolite concentrations. UHPLC-ESIOrbitrap-MS analysis identified 72 bioactive metabolites belonging to phenolics, triterpenoidal saponins, and pyridines In conclusion, A. spinosus could be a management approach for ovarian hyperthecosis therapy via regulating circRNA (hsacirc-0001577), disturbed hormonal balance, and metabolomics biomarkers based assays.
Influence of the use of a denture adhesive on salivary cells and candidal activity: A randomized clinical trial
(Elsevier Inc, 2025-05-17) Ahmed N. Elsherbini; Zeinab A. Elshereef; Tasneem M. Soliman
Statement of problem: Complete denture movement is inevitable and leads to mechanical irritation. Additional retention such as with adhesives can reduce mechanical irritation by reducing the denture movement but may be a chemical irritant. Whether these irritations can have an adverse effect on the salivary cells and oral infections is unclear. Purpose: The purpose of this randomized clinical trial was to evaluate the effect of complete denture retention, with or without a denture adhesive, on salivary cellular changes and Candida albicans activity Material and methods: Forty healthy, nonanemic, completely edentulous, male and female participants, between 40 and 60 years old were enrolled and randomly allocated into 2 equal groups. In one group, participants received conventional complete dentures without an adhesive. In the other group, participants received conventional complete dentures with an adhesive (Corega Super; GlaxoSmithKline). Saliva samples were collected in sterile containers for both groups before denture insertion, 1 month after insertion, and 3 months after insertion. Exfoliated squamous cells were examined regarding nuclear size (nuclear/cytoplasmic (N/C) ratio), chromatin distribution, regularity of nuclear membrane, prominent nucleolus, nuclear bi- or multinucleation, and Candida albicans count. Results: After 1 month and after 3 months in the group without an adhesive, no change was seen in the histological composition. However, in the group with an adhesive at 1 month after insertion, superficial and intermediate squamous cells were seen, with occasional reactive nuclear changes, showing enlarged nuclei and moderate inflammation polymorph nuclear leukocytes (PNLs). At 3 months after insertion, superficial and intermediate squamous cells were seen, with remarkable reactive nuclear changes, showing enlarged nuclei, binucleation, prominent nucleoli, and marked inflammation (PNLs). Conclusions: Provision of a complete denture did not alter the salivary cells; however, the use of a denture adhesive can lead to inflammatory responses of the salivary cells. © 2025 Editorial Council for The Journal of Prosthetic Dentistry
Unearthing the hidden path of MANET’s nodes with signal strength measurements: Forensics challenges, survey and a novel approach for data collection, preservation and examination
(Elsevier Ltd, 2025-05-16) Omar Ragheb; Mena Safwat; Marianne A. Azer
Mobile Ad hoc Networks (MANETs) are self-configuring networks of mobile devices that communicate with each
other without the need for infrastructure. This makes them highly flexible and adaptable to changing environments, making them ideal for applications such as transportation and tactical domains. However, the mobility
feature of the network poses new challenges for digital forensics investigators due to their specific characteristics.
One challenge is how the investigator can prove the Chain of Custody (COC) in court in this highly volatile
network to ensure the integrity of the evidence. This paper studies the forensic challenges in several wireless
technologies, including the Internet of Things (IoT), Vehicular Ad-hoc Networks (VANETs), and, especially in
Mobile Ad-hoc Networks (MANETs), critically reviews several approaches to cover the challenges, and also
proposes a novel digital forensics framework that is built on Fog Computing (FC). Using regular communication
signal strength measurements, the proposed framework enables investigators to learn details about nodes’ locations over time and mobility characteristics without requiring changes to communication protocols or overwhelming nodes with additional tasks. This can help to ensure the availability and integrity of the digital
evidence and its admissibility in court. Additionally, the paper suggests a novel automated detection technique
for Hello Flood attacks in ad-hoc networks. The viability of the approach has been demonstrated on a network
simulator.
Nodules-associated Klebsiella oxytoca complex: genomic insights into plant growth promotion and health risk assessment
(BioMed Central Ltd, 2025-05-15) Sameh H. Youseif; Fayrouz H. Abd El‑Megeed; May S. Soliman; Amr Ageez; Akram H. Mohamed; Saher A. Ali; Amani A. El‑Kholy
The swift emergence of antibiotic resistance genes (ARGs) across interconnected One Health compartments poses
a signifcant global threat. Although plant growth-promoting (PGP) bacteria possess numerous attributes benefcial
to host plants, many of these bacteria also harbor ARGs, necessitating a focused assessment of their negative implica‑
tions. In this context, here we performed whole genome sequencing of 14 PGP endophytic strains isolated from root
nodules of faba beans, belonging to three Klebsiella oxytoca species complex (KoSC): K. grimontii (n=5), K. michiganensis (n=5), and K. pasteurii (n=4). We performed comparative genomics, molecular typing, and pangenome analyses
on these strains. We identifed signifcant diversity within the KoSC population, classifying the strains into fve sequence
types (STs), three of which are novel to this study (ST-542, ST-569, and ST-629). Phylogenomic analysis revealed
that the bacterial strains clustered more closely by ST than by their source of isolation. Annotation of gene clusters indi‑
cated that all assembled genomes are enriched with genes involved in PGP activities, alongside a robust array of genes
conferring tolerance to abiotic stresses. Importantly, our fndings disclosed that the 14 assembled genomes harbored
multiple ARGs, conferring resistance to various antibiotic classes, with 71% of the population classifed as multidrugresistant based on the in vitro antibiotic susceptibility assay. Furthermore, all genomes contained an array of virulence
factors critical for survival, pathogenesis, bioflm formation, and root colonization. In conclusion, this study substantiates
the hypothesis that certain PGP bacteria may serve as potential reservoirs of multidrug resistance, posing signifcant
public health risks. Thus, the future advancement of bacteria-based biofertilizers should integrate environmental con‑
siderations and monitor their impact on antibiotic resistance dissemination in soil ecosystems.
When good brand communities go bad: an empirical investigation of oppositional behavior
(Routledge, 2025-05-14) Ahmed Eldegwy; Omneya A. Marzouk
This paper conceptualizes and empirically tests a model that examines oppositional behavior toward extracurricular activities (EAs) by integrating two separate streams of literature: higher education and sociology. Drawing on an empirical survey of 353 undergraduate students who hold leadership positions in EAs, this model was tested using structural equation modelling. The results suggest that identification with EAs influences the dislike of both other EAs and their members. Moreover, EA leaders who dislike other EAs and their members are more likely to engage in oppositional behavior – specifically, trash-talking other EAs. The results offer managerial implications as they shed light on a previously under-investigated phenomenon in the educational industry. The oppositional behavior construct and the resulting polarization of the student body may hold the potential to degrade the quality of students’ out-of-class experiences.