MSA Repository "MSAR"
MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.
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Evaluation of the Effect of Low-Level Laser Therapy Versus Photodynamic Therapy on the Level of Serum IL-17 and Salivary IL-4 in Patients Suffering from Erosive/Atrophic Oral Lichen Planus: A Case Control Study
(National Information and Documentation Centre, 2024-12-15) M. A. Sabry; M. E. Gheith; A. A. Hussine; A. M. Elsayed; S. H. Elkady; D. M. Abd El- Aziz
Background: One of the most common treatment modalities of oral lichen planus (OLP) is topical corticosteroids (TCS). However, it has
several side effects which are harmful to the patients. One such promising treatment modality is low level laser therapy (LLLT) as well as
photodynamic therapy (PDT) which are considered safe and reliable in reducing the painful symptoms of the disease with minimal side
effects. The inflammatory mediators; cytokines as (IL- 4 & IL- 17) were found to play a crucial role in the pathogenesis of atrophic/erosive
OLP.
Objective: The aim of this study is to investigate and compare the effect of PDT, LLLT & TCS by measuring the pain scale VAS, IL- 4 in
saliva and IL- 17 in serum to detect the response of OLP patients to these different modalities.
Methods: The study was conducted on 30 patients divided into 3 groups. Each group received either of 3 treatments; PDT, LLLT or TCS,
then VAS, salivary IL-4 and serum IL-17 were measured by ELISA at base line, immediately after the first session, at 2 and 4 months from
base line to detect the efficiency of each type of treatment.
Results: The use of PDT and LLLT were effective and superior to TCS in treatment of OLP in adult patients. Cytokines were reduced in the 3
groups and VAS was markedly reduced by LLLT. No correlation was found between any of the used parameters, this shows that each one of
the parameters was efficient on its own in monitoring the effectiveness of the three treatment modalities used.
Conclusions: the use of LLLT and PDT was effective in treatment of OLP in adult patients.
Pharmacovigilance in the Community: A Special‑Interest Group of the International Society of Pharmacovigilance
(Adis International Ltd, 2025-01-08) Mohamed A. Elhawary; Rebecca Noss; Loubna Alj; Manal Younus; Mayada Alkhakany; Hadir Rostom; Angela Caro‑Rojas; Thamir M. Alshammari
Pharmacovigilance (PV) continues to evolve globally and
has changed in the last few decades from depending on a
reactive approach based on spontaneous reporting of adverse
drug reactions (ADRs) to a more proactive and patient-centred approach [1]. To keep pace with these developments,
PV stakeholders should adopt a multidisciplinary framework
to release the untapped potential of their PV allies in the
community [2].
Community pharmacists are often regarded as "the frst
point of contact" among healthcare professionals (HCPs) due
to their high accessibility to the public [3]. However, on a
daily basis, patients collect their medications from the pharmacy without seeking any clarifcation. Pharmacy staf often
inquire, "Do you have any questions for the pharmacist?"
to which the response is frequently "no" [4]. This recurring dialogue in general does not allow the pharmacists to
inform the patients of any essential information with regard
to their medication. This lack of communication is a barrier
to adverse event reporting, if it occurs, and undermines trust
in healthcare systems. In turn, this can negatively impact on
compliance with medications and increase the susceptibility
to accepting misleading information.
Therefore, community pharmacists and other HCPs,
should be familiar with ways to communicate risk. It is
important for HCPs to be aware of the integrated PV landscape, which addresses all circumstances where safety issues
may occur (e.g., medication error, abuse, poor quality, misuse, and drug addiction and falsifed products) and to include
not only conventional medicines but also biological products
and herbal medicines.
Micro CT evaluation of marginal discrepancies of endocrown restored molars with different intrapulpal depths and materials of fabrication. (in-vitro study)
(BioMed Central Ltd, 2025-01-27) Mohamed Aly Mohamed Badr Elagwany; Amina Mohamed Hamdy; Maged Mohamed Zohdy; Aliaa Mahrous; Ahmed Tawfik; Soha Osama Nabih
Objective The purpose of this study was to evaluate the effect of different preparation depths (0, 2 and 4 mm) of
different restoration designs (classic endocrown design versus overlay design) on marginal adaptation of restorations
fabricated of two different restorative materials (lithium disilicate and PEEK).
Materials and methods Sixty mandibular natural molars were collected as abutments for the restorations of this
study, and grouped in three main groups of different cavity depths (0, 2 and 4). Each group was divided into two
subgroups according to material of fabrication to (L) for lithium disilicate (IPS emax CAD, Ivoclar vivadent, Switzarland)
and (P) for PEEK (Bio-hpp, Bredent, Germany). CAD/CAM milling technology was used for fabrication of restorations.
After cementation of restorations over abutments, hydrothermal aging was performed, and then marginal adaptation
was evaluated via micro CT technology.
Results Regarding cavity depths, there was a significant difference between different groups (p<0.001). The
highest value was found in samples with 4 mm extension (84.35±18.16), followed by samples with 2 mm extension
(66.52±21.86), while the lowest value was found in samples without pulpal extension (59.41±22.16). Post hoc
pairwise comparisons showed samples with 4 mm extension to have a significantly higher value than samples
without extension (p<0.001). Regarding materials of fabrication, PEEK (85.32±12.37) had a significantly higher value
than Emax (54.86±20.86) (p<0.001).
Conclusions Increasing intrapulpal cavity depths increases vertical marginal gap of lithium disilicate or PEEK
restorations. Endocrowns fabricated of lithium disilicate show less marginal discrepancies than that of endocrowns
fabricated of PEEK.
Seaweed valorization as anaerobic co-substrate with fat, oil, and grease: Biomethane potential and microbial dynamics
(Elsevier Ltd, 2025-02-05) Shah Faisal; Adel W. Almutairi; Irfan Saif; Li Ting; Qingyuan Wang; Ahmad Mustafa; Reham Ebaid
The present study explored the anaerobic co-digestion (AcD) of seaweed Gracilaria vermiculophylla with fat, oil, and grease (FOG) at 75, 50, and 25 % w/w of volatile solids (VS). Mono-digestion of FOG and SW led to a methane production of 133 and 109 mL/(g.d) with 40 days lag-phase, lower than 235 mL/(g.d) of AcD at FOG-50:SW-50 with reduced lag-phase of 20 days. The palmitic and oleic acid reduction was 95 % in the reactors FOG-50:SW-50, followed by FOG-25:SW-75, which was 84 %, as compared to FOG mono-digestion (47 %). Relative abundance of Firmicutes, Chloroflexi, and Bacteroidetes were enriched during AcD. The relative abundance of Methanosaeta was enhanced (40–90 %) in FOG-50:SW-50 compared with FOG-100:SW-0 as the reduction in Methanosaeta was replaced by Methanoculleus (30 %) and RuMen-M2 (10 %). The present study offers essential perspectives for the AcD of FOG with SW, showcasing the benefits of SW as a co-substrate for improved methane recovery from FOG.
Ondansetron alleviates testosterone-induced BPH in rats through cross regulation of the 5-HT/AR/P-STAT3 and the non-canonical NF-κB pathways
(Elsevier B.V., 2025-02-01) Reem A. Mohamed; Maha M. Shouman
Benign prostatic hyperplasia (BPH) is a widespread age-related health issue. Every year, new pathological cues
are revealed in the pathogenesis of BPH, however, the role of serotonin, Janus tyrosine kinase (JAK)-2/signal
transducer and activator of the transcription (STAT)-3 and non-canonical nuclear factor-kappa B (NF-κB p52)
pathways and their interaction with the androgen receptor (AR) in BPH are still not fully investigated.
Accordingly, the aim of the current study was to unveil the possible modulatory effect of ondansetron alone and
in combination with tamsulosin on these pathways and their utilization as therapeutic targets. Five groups of rats
were utilized; group 1 received corn oil to serve as normal control, while the other groups administered
testosterone (3 mg/kg, subcutaneously) dissolved in corn oil for 2 weeks followed by the co-administration of
either tamsulosin (0.2 mg/kg, orally), ondansetron (2 mg/kg, intraperitoneally) or their combination for another
15 days along with testosterone injections. All treatments improved kidney function (creatinine and blood urea
nitrogen), decreased oxidative stress (reduced glutathione and malondialdehyde), attenuated inflammation (NF-
κB, cyclooxygenase-2), decreased AR expression, NF-κB p52, P-STAT3, transforming growth factor beta-1 in
addition to markers of epithelial-mesenchymal transition (alpha smooth muscle actin and vimentin) this was
associated with an increase in the prostatic content of serotonin, improvement in the histopathological picture
and overall shrinkage in relative prostate weight. These results show that ondansetron is a very promising
treatment for BPH especially in combination with tamsulosin and unveiled NF-κB p52 and serotonin as novel
therapeutic targets in the management of BPH.