MSA Repository "MSAR"

MSAR University's Digital Repository is a documentation and digitization of all university outcomes that are of effective value in the scientific and academic community and reflects the university's image, work, and effective contribution to society Through MSAR Digital Repository, the university managed to collect, store, archive and publish digital content - including documents, audio files, images and data sets - all in a safe place. MSAR is one of the strongest University Digital Repositories in Egypt and documented in the DSPACE community with its latest versions.

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    Fracture resistance of maxillary lateral incisors: effects of fiber post dimensions, material, and surface treatment
    (BioMed Central Ltd, 2026-07-04) Maria Reslan; Dana El Ballouli; Rana Walid Tawil; Mohamed Sayed; Maha Fouad; Alaa Mohamed Naguib; Hend Ashraf AbdelHadi; Abdelrahman Mustafa El Sokkary; Esraa AbdelGhany; Abdel Rahman O. El Mekkawi; Sahar Mokhtar; Ehab A. Farghaly; Rehab Ali Farag; Mohammad Rayyan
    Background: Fiber-reinforced posts are widely used to restore endodontically treated anterior teeth, yet the relative contributions of post length, diameter, material, and surface treatment to fracture resistance in maxillary lateral incisors remain unclear. Purpose: To determine the individual and interactive effects of fiber post length, diameter, material, and surface treatment on the fracture resistance and failure modes of endodontically treated maxillary lateral incisors restored with composite cores and monolithic zirconia crowns. Methods: In a controlled laboratory study (2 × 2 × 2 × 2 design; 16 groups; n = 10/group; N = 160), extracted maxillary lateral incisors received standardized endodontic treatment, fiber post placement, composite core build-ups, and monolithic 5Y-PSZ zirconia crowns. Factors were: post length (8 vs. 12 mm), diameter (0.9 vs. 1.1 mm), post material/system (tested glass-fiber post system vs. tested quartz-fiber post system), and surface treatment (ethanol-cleaned vs. airborne-particle abrasion + silane). A uniform 2-mm ferrule, PDL simulation, and epoxy embedding were used. Specimens were thermocycled (10,000 cycles, 5–55 °C) and loaded at 135° to the long axis with a 3-mm indenter until failure; maximum load (N) and failure mode (repairable vs. non-repairable) were recorded. Data were analyzed with fixed-effects factorial ANOVA (Tukey post hoc) and χ² tests (α = 0.05). Results: Mean fracture load ranged from 655 ± 62 N to 971 ± 65 N. Main effects were additive: 12-mm length (+ 86.9 N), 1.1-mm diameter (+ 76.7 N), the tested quartz-fiber post system (+ 55.0 N) and abrasion+silane (+ 36.3 N) increased load (all P ≤ .010), with no interactions (all P ≥ .075). Higher-strength configurations showed fewer catastrophic root fractures. Conclusions: Within the tested, anatomy-preserving ranges, longer and slightly 1.1 mm diameter posts, the tested quartz-fiber post system and abrasion-plus-silane conditioning can be combined to improve fracture resistance in restored maxillary lateral incisors, supporting strategies that maximise bonding while preserving dentine. Limitation/future work: As an in vitro static test with thermal ageing only, cyclic fatigue and long-term interface degradation remain uncertain and should be evaluated in fatigue models and clinical trials.
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    Epstein-Barr Virus MicroRNAs as Key Regulators of Lymphoma Pathogenesis: Immune Evasion Mechanisms and Therapeutic Opportunities
    (John Wiley and Sons Inc, 2026-06-28) Rasha Abu-Khudir; Ahmed S. Doghish; Hend H. Mohamed; Nehal I. Rizk; Haidy Adel Fahmy; Salma Zaki Fayez; Yara Ashraf; Ayatallah Elgohary; Hager Nasser Selim; Moustafa Mahmoud Abdelaziz; Osama A. Mohammed; Sherif S. Abdel Mageed; Rabab S. Hamad; Reda M. Mansour
    The ubiquitous human gamma-herpesvirus Epstein–Barr virus (EBV) infects over 90% of adults globally and was the first human virus identified with oncogenic potential. EBV enters a lifelong persistence in the host via a finely regulated life-cycle comprising primary infection, latency and lytic reactivation. Within infected B-cells and epithelial cells, EBV encodes a distinct repertoire of microRNAs (miRNAs), primarily from the BART (BamHI A rightward transcript) and BHRF1 (BamHI H rightward open reading frame) clusters, which play pivotal roles in modulating both viral and host gene expression. These viral miRNAs contribute to key oncogenic processes: by dampening apoptotic responses (e.g., via targeting PUMA, Bim, and PTEN), promoting proliferation of latently-infected B-cells, inhibiting host immune responses (e.g., via down-regulation of CXCL-11 by miR-BHRF1-3), and promoting epithelial-mesenchymal transition (EMT) and metastasis through modulation of E-cadherin and other adhesion molecules. In human lymphomas, such as Burkitt lymphoma, Hodgkin lymphoma, and EBV-positive diffuse large B-cell lymphoma, the interplay of latent viral gene expression, miRNA-mediated regulatory networks, and host microenvironmental factors underlies malignant transformation and disease progression. Emerging evidence also supports the utility of EBV-encoded miRNAs as diagnostic and prognostic biomarkers in EBV-associated cancers. Importantly, therapeutic strategies aimed at interrupting viral miRNA function, restoring host tumor-suppressor pathways, and re-sensitizing tumor cells to immune surveillance hold promise. This review synthesizes current mechanistic insights into EBV-encoded miRNAs in oncogenesis, elaborates on their roles in lymphoma pathogenesis, and evaluates the translational potential of miRNA-targeted therapies in EBV-associated malignancies.
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    Framing Inclusive Heritage Urbanism Reconfiguring Publicness in Mosque-Centered Precincts in Historic Cairo
    (Publisher Mansoura University, Faculty of Engineering, 2026-06-12) Ghada S. Ghazala
    Mosque-centered precincts in historical cities face a continuous tension between touristic-led redevelopments, security management policies and urban life of commons. Recently in Historic Cairo state-led interventions occur in major mosque-centered settings with upgrading intent by enhancing visual order, crowd control and visitors’ experience, yet socio-spatial inclusivity stayed insufficiently incorporated in those implications. This study discourses this gap by initiating the Heritage Socio-spatial Inclusivity Framework (HSIF) to assess inclusivity across major mosque-centered realms – AL-Hussein Mosque & Al-Sayida Zeinab Mosque precincts . HSIF synthesized urban design & heritage conservation concepts through indicators covering aspects like communal livability, users experience, governance & heritage sustainability. The study aimed to propose context-sensitive guidelines that balance tourism pressures, governance and locals’ rights to urban heritage, through operationalizing HSIF as a diagnostic tool afore prescriptive model. Empirically; the study adopted a triangulated methodology of analysis by integrating users’ surveys, mapped on-site observations & historical precedence of urban morphological evolutions. The outcomes demonstrated an operational imbalance; as the state-led interventions helped enhancing the precincts’ vitality, temporal inclusivity, visual and spatial experience yet a vivid weakness in participatory governance, access equity and heritage incorporation in everyday life was witnessed. These results exhibited that inclusivity in rich-heritage precincts exists yet reshaped in a form of consumption-oriented publicness marginalizing commons needs and authenticity. Therefore, the study proposed three clusters of context-sensitive guidelines and their implementations each address a weakness while strategically leveraging high performing indicators for inclusive outcomes; paving the road for a sustaining users’ sense of inclusivity in rich-heritage precincts.
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    Clinical Outcomes of Extraction-Guided Driftodontics
    (Journal of Clinical Orthodontics, 2026-06) Dalia El-Bokle; Neal D Kravitz
    Three adolescent cases demonstrate the clinical application of “driftodontics” following strategic premolar extractions. Natural dental drift appeared to facilitate spontaneous tooth movement during the early treatment phase, including canine descent, incisor retroclination, and space redistribution. The findings illustrate the potential of natural dental drift as an adjunctive mechanism in malocclusion management, with possible implications for simplifying and shortening orthodontic treatment. Keywords: case studies, dental drift, driftodontics, malocclusion management, premolar extractions.
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    Fiscal Antibodies: How Public Health Expenditures Strengthen National Economic Vulnerability to Climate Change
    (Multidisciplinary Digital Publishing Institute (MDPI), 2026-06-12) Abdelmoneim Bahyeldin Mohamed Metwally; Mai M. Yasser
    This study investigates the relationship between public health expenditures and national climate vulnerability, measured by the Notre Dame Global Adaptation Initiative (ND-GAIN) Index, across 62 developed and developing countries from 2000 to 2023. Motivated by contradictory findings in the prior literature and a lack of large-scale panel econometric evidence, this research aims to determine whether health investments significantly increase climate vulnerability. Using a dynamic generalized method of moments (GMM), the findings show that public health expenditure per capita has a statistically significant positive impact on the ND-GAIN composite index. Findings show that public health expenditure per capita has a statistically significant positive impact on the ND-GAIN composite index—where higher ND-GAIN values indicate lower climate vulnerability and greater adaptive capacity—implying that increased public health spending is associated with reduced national climate vulnerability. In high-income countries, health spending may improve adaptive capacity by leveraging established infrastructure and governance. As a result, policymakers should make funding for public health a top priority in their plans for adapting to climate change. This is because investing in health alone is not enough; they also need to invest in infrastructure, governance, and adaptive capacity, especially in developing countries.