Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarag A.G.A.
dc.contributor.authorBasha M.A.
dc.contributor.authorAmin S.A.
dc.contributor.authorElnaidany N.F.
dc.contributor.authorElhelbawy N.G.
dc.contributor.authorMostafa M.M.T.
dc.contributor.authorKhodier S.A.
dc.contributor.authorIbrahem R.A.
dc.contributor.authorMahfouz R.Z.
dc.contributor.otherDermatology
dc.contributor.otherAndrology and STDs
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El Kom
dc.contributor.otherEgypt; Forensic Medicine & Clinical Toxicology
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El Kom
dc.contributor.otherEgypt; Faculty of Pharmacy
dc.contributor.otherClinical Pharmacy
dc.contributor.otherMSA University
dc.contributor.other6 October City
dc.contributor.otherEgypt; Faculty of Medicine
dc.contributor.otherMedical Biochemistry
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El Kom
dc.contributor.otherEgypt; Faculty of Medicine
dc.contributor.otherClinical Pathology
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El Kom
dc.contributor.otherEgypt; Faculty of Medicine
dc.contributor.otherPublic Health and Community Medicine
dc.contributor.otherMenoufia University
dc.contributor.otherShebin El Kom
dc.contributor.otherEgypt; Cleveland Clinic Lerner College of Medicine
dc.contributor.otherCase Western Reserve University
dc.contributor.otherCleveland
dc.contributor.otherOH
dc.contributor.otherUnited States
dc.date.accessioned2020-01-09T20:40:53Z
dc.date.available2020-01-09T20:40:53Z
dc.date.issued2018
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractTramadol, one of the most commonly abused drugs in Middle East, impacts spermatogenesis and disturbs reproductive hormones in animal studies. We aimed to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n=30) to age-matched control (n=30). Abusers had significantly low percentages of sperm motility, normal forms and vitality compared with control (95% CI ?40.7 to ?19.3, ?13.5 to ?9.3 and ?31.9 to ?9.7 respectively). Hypoandrogenism (95% CI ?4.5 to ?2.8), hyperprolactinaemia (CI (95%) 4.9 to 9.4) and hypergonadotropinaemia (95% CI 2.9 to 7.2 for FSH and 2.0 to 7.8 for LH) were observed in tramadol abusers vs controls. Smokers (26 of 30), concurrently abusing other drugs (11 of 30) and asymptomatic leucocytospermic (15 of 30) patients subgroups significantly abused tramadol beyond 3years (p=.02, <.001, =.03 respectively) and in excess >450mg/day (p=.02, =.01, =.005 respectively). Progressive motility (a+b%) was significantly low in young men <25years old (p=.03) subgroup. Tramadol abuse is associated with poor sperm quality, hyperprolactinaemia and hypergonadotropic hypogonadism. We recommend semen analysis for tramadol long-intakes, question sperm donors and follow-up studies to prevent and reverse tramadol-induced testicular damage. � 2018 Blackwell Verlag GmbHen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=27111&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1111/and.13026
dc.identifier.doiPubMed ID 29781510
dc.identifier.issn3034569
dc.identifier.otherhttps://doi.org/10.1111/and.13026
dc.identifier.otherPubMed ID 29781510
dc.identifier.urihttps://t.ly/z5rEZ
dc.language.isoEnglishen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofseriesAndrologia
dc.relation.ispartofseries50
dc.subjectopioidsen_US
dc.subjectprolactinen_US
dc.subjectsperm qualityen_US
dc.subjecttesticular functionen_US
dc.subjecttramadolen_US
dc.subjectfollitropinen_US
dc.subjectgonadotropinen_US
dc.subjectluteinizing hormoneen_US
dc.subjectprolactinen_US
dc.subjecttestosteroneen_US
dc.subjecttramadolen_US
dc.subjectgonadotropinen_US
dc.subjectnarcotic analgesic agenten_US
dc.subjectprolactinen_US
dc.subjecttestosteroneen_US
dc.subjecttramadolen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectasymptomatic leucocytospermiaen_US
dc.subjectasymptomatic leucocytospermiaen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdisorders of hormone metabolismen_US
dc.subjectdrug abuseen_US
dc.subjectdrug dependenceen_US
dc.subjectfollow upen_US
dc.subjecthumanen_US
dc.subjecthypergonadotropic hypogonadismen_US
dc.subjecthypergonadotropinemiaen_US
dc.subjecthypergonadotropinemiaen_US
dc.subjecthyperprolactinemiaen_US
dc.subjecthypoandrogenismen_US
dc.subjecthypoandrogenismen_US
dc.subjectmaleen_US
dc.subjectprolactin blood levelen_US
dc.subjectsemen analysisen_US
dc.subjectsmokingen_US
dc.subjectsperm donoren_US
dc.subjectsperm qualityen_US
dc.subjectspermatozoon motilityen_US
dc.subjectsubstance abuseen_US
dc.subjectadolescenten_US
dc.subjectcomplicationen_US
dc.subjectdrug effecten_US
dc.subjectepidemiologyen_US
dc.subjecthyperprolactinemiaen_US
dc.subjecthypogonadismen_US
dc.subjectmetabolismen_US
dc.subjectMiddle Easten_US
dc.subjectopiate addictionen_US
dc.subjectspermatogenesisen_US
dc.subjectspermatozoon motilityen_US
dc.subjecttestisen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAnalgesics, Opioiden_US
dc.subjectGonadotropinsen_US
dc.subjectHumansen_US
dc.subjectHyperprolactinemiaen_US
dc.subjectHypogonadismen_US
dc.subjectMaleen_US
dc.subjectMiddle Easten_US
dc.subjectOpioid-Related Disordersen_US
dc.subjectProlactinen_US
dc.subjectSemen Analysisen_US
dc.subjectSmokingen_US
dc.subjectSperm Motilityen_US
dc.subjectSpermatogenesisen_US
dc.subjectTestisen_US
dc.subjectTestosteroneen_US
dc.subjectTramadolen_US
dc.titleTramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young menen_US
dc.typeArticleen_US
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