Spectrophotometric determination of sitagliptin and metformin in their pharmaceutical formulation
Date
2012
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Pharmacie Globale
Series Info
Pharmacie Globale;Volume: 3 Issue: 5 Pages: 1-4
Doi
Scientific Journal Rankings
Abstract
Two simple, accurate and precise spectrophotometric methods were developed and validated for the
determination of sitagliptin phosphate monohydrate (STA) and metformin hydrochloride (MTF). The first method
was based on measuring the absorbance of STA at 268 nm in the range of 25-500 µg mL-1. The second method was
the isosbestic point method. The total mixture concentration was calculated by measuring the absorbance at 257
nm. The proposed methods used to determine each drug in binary mixture. The results were statistically
compared using one-way analysis of variance (ANOVA). The developed methods were satisfactory applied to the
analysis of the pharmaceutical formulation and proved to be selective and accurate for the quality control of the
cited drugs in their pharmaceutical formulation.
Description
MSA Google Scholar
Keywords
University of metformin; sitagliptin phosphate; spectrophotometry.
Citation
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