Recent Updates in Pharmacological Properties of Chitooligosaccharides

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMarmouzi I.
dc.contributor.authorEzzat, Shahira M
dc.contributor.authorSalama M.M.
dc.contributor.authorMerghany R.M.
dc.contributor.authorAttar A.M.
dc.contributor.authorEl-Desoky A.M.
dc.contributor.authorMohamed S.O.
dc.contributor.otherUniversity Mohammed v in Rabat
dc.contributor.otherFacult� de M�dicine et Pharmacie
dc.contributor.otherLaboratoire de Pharmacologie et Toxicologie
dc.contributor.other�quipe de Pharmacocin�tique
dc.contributor.otherRabat
dc.contributor.otherMorocco; Pharmacognosy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr El-Ainy Street
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.other6th October12611
dc.contributor.otherEgypt; Department of Pharmacognosy and Medicinal Plants
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherBritish University in Egypt
dc.contributor.otherCairo
dc.contributor.other11837
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherNational Research Centre
dc.contributor.otherGiza
dc.contributor.otherEgypt; Faculty of Science and Techniques
dc.contributor.otherHassan II University of Casablanca
dc.contributor.otherMohammedia
dc.contributor.otherMorocco; Department of Molecular Biology
dc.contributor.otherGenetic Engineering and Biotechnology Research Institute (GEBRI)
dc.contributor.otherUniversity of Sadat City (USC)
dc.contributor.otherSadat City
dc.contributor.otherEgypt; Natural Wellness Scientific Office
dc.contributor.otherKuala Lumpur
dc.contributor.otherMalaysia
dc.date.accessioned2020-01-09T20:40:47Z
dc.date.available2020-01-09T20:40:47Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractChemical structures derived from marine foods are highly diverse and pharmacologically promising. In particular, chitooligosaccharides (COS) present a safe pharmacokinetic profile and a great source of new bioactive polymers. This review describes the antioxidant, anti-inflammatory, and antidiabetic properties of COS from recent publications. Thus, COS constitute an effective agent against oxidative stress, cellular damage, and inflammatory pathogenesis. The mechanisms of action and targeted therapeutic pathways of COS are summarized and discussed. COS may act as antioxidants via their radical scavenging activity and by decreasing oxidative stress markers. The mechanism of COS antidiabetic effect is characterized by an acceleration of pancreatic islets proliferation, an increase in insulin secretion and sensitivity, a reduction of postprandial glucose, and an improvement of glucose uptake. COS upregulate the GLUT2 and inhibit digestive enzyme and glucose transporters. Furthermore, they resulted in reduction of gluconeogenesis and promotion of glucose conversion. On the other hand, the COS decrease inflammatory mediators, suppress the activation of NF-B, increase the phosphorylation of kinase, and stimulate the proliferation of lymphocytes. Overall, this review brings evidence from experimental data about protective effect of COS. � 2019 Ilias Marmouzi et al.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100230018&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1155/2019/4568039
dc.identifier.doiPubMed ID 31781615
dc.identifier.issn23146133
dc.identifier.otherhttps://doi.org/10.1155/2019/4568039
dc.identifier.otherPubMed ID 31781615
dc.identifier.urihttps://t.ly/2dw29
dc.language.isoEnglishen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofseriesBioMed Research International
dc.relation.ispartofseries2019
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectchitooligosaccharideen_US
dc.subjectoligosaccharideen_US
dc.subjectunclassified drugen_US
dc.subjectantidiabetic activityen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectdrug activityen_US
dc.subjecthumanen_US
dc.subjectnonhumanen_US
dc.subjectReviewen_US
dc.titleRecent Updates in Pharmacological Properties of Chitooligosaccharidesen_US
dc.typeReviewen_US
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