Antioxidant activity and molecular docking study of Erythrin neillii polyphenolics

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorGabr S.K.
dc.contributor.authorBakr R.O.
dc.contributor.authorMostafa E.S.
dc.contributor.authorEl-Fishawy A.M.
dc.contributor.authorEl-Alfy T.S.
dc.contributor.otherDepartment of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherGiza
dc.contributor.other11787
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:40Z
dc.date.available2020-01-09T20:40:40Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractSpecies of genus Erythrina have a great contribution in folk medicine; various species are utilized as a tranquilizer, to treat insomnia, inflammation and colic. Besides, Erythrina species have reported antioxidant, hepatoprotective and anxiolytic activities. Erythrina neillii is a hybrid obtained through a cross between E. herbacea L. and E. humeana Spreng. It has not been well-studied for its chemical or biological profile; therefore it represents an interesting field of study. In this study, seven phenolic compounds; two hydrolysable tannins (1,3), one phenolic acid (2) and four known flavonoids (4�7) were isolated and characterized for the first time in E neillii and Erythrina genus except for vitexin (7). Isolated compounds were assessed for their antioxidant activities using ORAC assay. 2?-O-galloyl orientin (6) exhibited the highest activity followed by 2?-O-galloyl vitexin (5). Flexible molecular docking on heme oxygenase, an important stress protein that is involved in cellular protection, antioxidant and anti-inflammatory activities, justified the antioxidant activity of the isolated compounds. The best scoring was observed with 2?-O-galloyl orientin forming four binding interactions with residues, Arg 136 (two interactions), Met34 and Gly139. Erythrina neillii offered powerful and available antioxidant beside significantly active phytoconstituents. 2018 South African Association of Botanistsen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=17257&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.sajb.2018.12.011
dc.identifier.doiPubMed ID :
dc.identifier.issn2546299
dc.identifier.otherhttps://doi.org/10.1016/j.sajb.2018.12.011
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/b2jYZ
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesSouth African Journal of Botany
dc.relation.ispartofseries121
dc.subjectDockingen_US
dc.subjectErythrina neilliien_US
dc.subjectHeme oxygenaseen_US
dc.subjectORACen_US
dc.subjectPolyphenolicsen_US
dc.subjectantioxidanten_US
dc.subjectbiochemistryen_US
dc.subjectcellen_US
dc.subjectchemical bindingen_US
dc.subjectenzymeen_US
dc.subjectenzyme activityen_US
dc.subjectherben_US
dc.subjectmolecular analysisen_US
dc.subjectphenolic compounden_US
dc.subjectproteinen_US
dc.subjecttanninen_US
dc.subjectErythrina herbaceaen_US
dc.titleAntioxidant activity and molecular docking study of Erythrin neillii polyphenolicsen_US
dc.typeArticleen_US
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