Tamoxifen citrate/Coenzyme Q10 as smart nanocarriers Bitherapy for Breast Cancer: Cytotoxicity, genotoxicity, and antioxidant activity

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Leithy E.S.
dc.contributor.authorHassan S.A.
dc.contributor.authorAbdel-Rashid R.S.
dc.contributor.otherDepartment of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Pharmacy
dc.contributor.otherDepartment of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Therapeutic Chemistry Dept
dc.contributor.otherNational Research Center
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:37Z
dc.date.available2020-01-09T20:40:37Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractNanotechnology-based bitherapy has recently emerged as an effective strategy to overcome biomedical barriers against successful anticancer therapy. The study aimed to evaluate lipid nanocarriers loaded with tamoxifen citrate/coenzyme Q10 (TC/CoQ10) as bitherapy for selective targeting of breast cancer. Based on a previous study, four formulations of lipid nanocarriers were selected for in-vitro cell viability estimation using both MCF-7 and normal WISH cell lines. Oxidative status, cytopathological changes, and genetoxicity were also investigated. The results showed 100% mortality for tested cells without selectivity even at very low concentration for free drugs. On the other hand lipid nanocarriers revealed an increase in % cell viability for normal WISH cell line reaching 100% at 0.25 ?g/ml. The lipid nanocarrier formulated from stearic acid and lecithin showed LC 50 on MCF-7 cell line (1.6 ?g/ml) compared to (4.8 ?g/ml) on WISH cell line. The cell death pathway for unformulated bitherapy depended on necrosis rather than apoptosis. The Malondialdehyde concentration was decreased, while Glutathione level increased to near normal values in both MCF-7 and WISH cells. The results demonstrated a promising synergistic and selective action of TC/CoQ10 bitherapy on breast cancer cells when administered in lipid nanocarriers delivery system. � 2019 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=22204&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.jddst.2019.02.010
dc.identifier.doiPubMed ID :
dc.identifier.issn17732247
dc.identifier.otherhttps://doi.org/10.1016/j.jddst.2019.02.010
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/LXZw0
dc.language.isoEnglishen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofseriesJournal of Drug Delivery Science and Technology
dc.relation.ispartofseries51
dc.subjectAntioxidant activityen_US
dc.subjectBreast canceren_US
dc.subjectCoenzyme Q10en_US
dc.subjectCytotoxicityen_US
dc.subjectLipid nanocarriersen_US
dc.subjectTamoxifen citrateen_US
dc.subjectglutathioneen_US
dc.subjectmalonaldehydeen_US
dc.subjectnanocarrieren_US
dc.subjectphosphatidylcholineen_US
dc.subjectstearic aciden_US
dc.subjecttamoxifen citrateen_US
dc.subjectubidecarenoneen_US
dc.subjectantioxidant activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbitherapyen_US
dc.subjectbreast canceren_US
dc.subjectcancer cell cultureen_US
dc.subjectcell deathen_US
dc.subjectcell viabilityen_US
dc.subjectcomet assayen_US
dc.subjectcytopathologyen_US
dc.subjectdrug delivery systemen_US
dc.subjectgenotoxicityen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjecthuman cell cultureen_US
dc.subjectin vitro studyen_US
dc.subjectLC50en_US
dc.subjectMCF-7 cell lineen_US
dc.subjectmicroemulsionen_US
dc.subjectnanotechnologyen_US
dc.subjectparticle sizeen_US
dc.subjectultrasounden_US
dc.subjectWISH cell lineen_US
dc.subjectzeta potentialen_US
dc.titleTamoxifen citrate/Coenzyme Q10 as smart nanocarriers Bitherapy for Breast Cancer: Cytotoxicity, genotoxicity, and antioxidant activityen_US
dc.typeArticleen_US
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