Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats
| dc.Affiliation | October University for modern sciences and Arts MSA | |
| dc.contributor.author | El-Shehry, Mona S. E. F | |
| dc.contributor.author | Amrymi, Rafa A | |
| dc.contributor.author | Atia, Tarek | |
| dc.contributor.author | Lotfy, Bassant M. M | |
| dc.contributor.author | Ahmed, Salma H. A | |
| dc.contributor.author | Qutb, Sarah A | |
| dc.contributor.author | Ali, Sara B | |
| dc.contributor.author | Mohamed, Ayman S | |
| dc.contributor.author | Mousa, Mohamed R | |
| dc.contributor.author | Damanhory, Ahmed A | |
| dc.contributor.author | Metawee, Mostafa E | |
| dc.contributor.author | Sakr, Hader I | |
| dc.date.accessioned | 2024-01-11T18:38:50Z | |
| dc.date.available | 2024-01-11T18:38:50Z | |
| dc.date.issued | 2023-12 | |
| dc.description | SJR 2024 0.625 Q1 H-Index 124 | |
| dc.description.abstract | Background: Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins. Aim: Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats. Methods: Eighteen rats were divided into three groups (n = 6): the control group, the phenylhydrazine-induced HA group and the Ech group, injected intraperitoneally with PHZ and supplemented with oral Ech daily for 6 days. Results: Ech resulted in a considerable increase in RBCs, WBCs, and platelets counts, hemoglobin, reduced glutathione, catalase, and glutathione-S-transferase levels, and a significant decrease in aspartate & alanine aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, creatinine, urea, urate, malondialdehyde & nitric oxide levels in anemic rats. Histopathological examination of liver and kidney tissue samples showed marked improvement. Conclusion: Ech ameliorated phenylhydrazine-induced HA with a hepatorenal protective effect owing to its anti-inflammatory and antioxidant properties. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=21100239256&tip=sid&clean=0 | |
| dc.identifier.citation | El-Shehry, M. S. E. F., Amrymi, R. A., Atia, T., Lotfy, B. M. M., Ahmed, S. H. A., Qutb, S. A., Ali, S. B., Mohamed, A. S., Mousa, M. R., Damanhory, A. A., Metawee, M. E., & Sakr, H. I. (2023). Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats. PeerJ, 11, e16576. https://doi.org/10.7717/peerj.16576 | |
| dc.identifier.doi | https://doi.org/10.7717/peerj.16576 | |
| dc.identifier.other | https://doi.org/10.7717/peerj.16576 | |
| dc.identifier.uri | http://repository.msa.edu.eg/xmlui/handle/123456789/5810 | |
| dc.language.iso | en | en_US |
| dc.publisher | PeerJ Inc | en_US |
| dc.relation.ispartofseries | PeerJ;11:e16576 | |
| dc.subject | Hemolytic Anemia, Echinochrome, Oxidative stress, Phenylhydrazine | en_US |
| dc.title | Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats | en_US |
| dc.type | Article | en_US |