Alginate coated chitosan nanogel for the controlled topical delivery of Silver sulfadiazine

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Feky G.S.
dc.contributor.authorEl-Banna S.T.
dc.contributor.authorEl-Bahy G.S.
dc.contributor.authorAbdelrazek E.M.
dc.contributor.authorKamal M.
dc.contributor.otherPharmaceutical Technology Department
dc.contributor.otherNational Research Center
dc.contributor.otherDokkiCairo
dc.contributor.otherEgypt; Faculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherEgypt; Spectroscopy Department
dc.contributor.otherPhysics Division
dc.contributor.otherNational Research Centre
dc.contributor.otherDokki
dc.contributor.otherGiza
dc.contributor.otherEgypt; Physics Department
dc.contributor.otherFaculty of Science
dc.contributor.otherMansoura University
dc.contributor.otherMansoura
dc.contributor.otherEgypt; Physics Department
dc.contributor.otherFaculty of Science
dc.contributor.otherTaibah University
dc.contributor.otherAl-Ula
dc.contributor.otherSaudi Arabia
dc.date.accessioned2020-01-09T20:41:11Z
dc.date.available2020-01-09T20:41:11Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractBurn wounds environment favors the growth of micro-organisms causing delay in wound healing. The traditional treatment with antimicrobial creams offer inaccurate doses. The aim of the present study is to formulate and evaluate different silver sulfadiazine loaded nanogel formulations. A factorial design experiment was used for the identification of critical process parameters and for the optimization of the respective process conditions. The prepared drug loaded nanogels were characterized for their particle size, zeta potential, entrapment efficiency and swelling index in order to demonstrate their physicochemical properties, in addition, FTIR, TEM, SEM and in vitro release were used for characterization. The release profile of all tested nanogels showed an initial burst followed by a slow and continuous release rate. An optimum nanogel formulation was predicted by the JMP� software according to the stated prediction expressions and was composed of 0.4% sodium alginate (ALG) and 0.414% Silver sulfadiazine (SSD). The optimized formulation showed higher therapeutic efficacy in vivo when compared to market product. � 2017 Elsevier Ltden_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=25801&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2017.08.104
dc.identifier.doiPubMed ID 28962758
dc.identifier.issn1448617
dc.identifier.otherhttps://doi.org/10.1016/j.carbpol.2017.08.104
dc.identifier.otherPubMed ID 28962758
dc.identifier.urihttps://t.ly/7OJ2B
dc.language.isoEnglishen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofseriesCarbohydrate Polymers
dc.relation.ispartofseries177
dc.subjectChitosanen_US
dc.subjectDrug deliveryen_US
dc.subjectNanogelsen_US
dc.subjectSilver sulfadiazineen_US
dc.subjectSodium alginateen_US
dc.subjectTripolyphosphateen_US
dc.subjectAlginateen_US
dc.subjectChitinen_US
dc.subjectChitosanen_US
dc.subjectDrug deliveryen_US
dc.subjectMicroorganismsen_US
dc.subjectParticle sizeen_US
dc.subjectPolyethylenesen_US
dc.subjectSilveren_US
dc.subjectSodiumen_US
dc.subjectSodium alginateen_US
dc.subjectCritical process parametersen_US
dc.subjectEntrapment efficiencyen_US
dc.subjectNanogelsen_US
dc.subjectPhysicochemical propertyen_US
dc.subjectProcess conditionen_US
dc.subjectSilver sulfadiazinesen_US
dc.subjectTherapeutic efficacyen_US
dc.subjectTripolyphosphatesen_US
dc.subjectNanostructured materialsen_US
dc.subjectalginic aciden_US
dc.subjectchitosanen_US
dc.subjectdrug carrieren_US
dc.subjectnanoparticleen_US
dc.subjectsulfadiazine silveren_US
dc.subjectadministration and dosageen_US
dc.subjectchemistryen_US
dc.subjectgelen_US
dc.subjecttopical drug administrationen_US
dc.subjectAdministration, Topicalen_US
dc.subjectAlginatesen_US
dc.subjectChitosanen_US
dc.subjectDrug Carriersen_US
dc.subjectGelsen_US
dc.subjectNanoparticlesen_US
dc.subjectSilver Sulfadiazineen_US
dc.titleAlginate coated chitosan nanogel for the controlled topical delivery of Silver sulfadiazineen_US
dc.typeArticleen_US
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