A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt
Date
2011
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Verlag der Zeitschrift für Naturforschung
Series Info
Z. Naturforsch.;66 c, 251 – 259
Scientific Journal Rankings
Abstract
A bioactivity-guided fractionation of the ethyl acetate fraction of the ffowers of Onopordum alexandrinum L.(Asteraceae) yielded a new ffavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known ffavonoids; 6-methoxy-apigenin (hispidulin)(1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity using 2, 2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 4, 6, 9, and 10 have not been previously reported from ffowers of O. alexandrinum L., and this is the first report of acacetin-7-O-galacturonide (9) in nature which has also shown significant hepatoprotective and free radical scavenging effects. The isolated compounds were
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Keywords
Onopordum alexandrinum, Acacetin-7-O-galacturonide, Hepatoprotective