Synthesis and biodistribution of 99mTc-PyDA as a potential marker for tumor hypoxia imaging

dc.Affiliation	October University for modern sciences and Arts (MSA)
dc.contributor.author	Sakr, TM
dc.contributor.author	Essa, BM
dc.contributor.author	El-Essawy, FA
dc.contributor.author	El-Mohty, AA
dc.date.accessioned	2020-02-12T09:26:33Z
dc.date.available	2020-02-12T09:26:33Z
dc.date.issued	2014
dc.description	MSA Google Scholar	en_US
dc.description.abstract	The 99mTc-pyrimidine-4,5-diamine (99mTc-PyDA) complex was prepared. The yield under the optimum conditions (5 mg of PyDA, pH 8, 25 μg of SnCl2·2H2O) was 96 ± 3%. The complex is stable in vitro for 24 h. The complex was tested on mice as potential marker for tumor hypoxia imaging. The complex showed high tumor hypoxia uptake with the target/nontarget (T/NT) ratio as high as ∼3.	en_US
dc.description.sponsorship	Springer	en_US
dc.description.uri	https://www.scimagojr.com/journalsearch.php?q=27036&tip=sid&clean=0
dc.identifier.doi	https://doi.org/10.1134/S1066362214010159
dc.identifier.issn	1066-3622
dc.identifier.other	https://doi.org/10.1134/S1066362214010159
dc.identifier.uri	https://cutt.ly/krJOYot
dc.language.iso	en	en_US
dc.publisher	SPRINGER	en_US
dc.relation.ispartofseries	Radiochemistry;VOL : 56 Issue : 1
dc.subject	Technetium-99m	en_US
dc.subject	pyrimidine	en_US
dc.subject	labeling	en_US
dc.subject	biodistribution	en_US
dc.subject	hypoxia	en_US
dc.subject	tumor	en_US
dc.subject	imaging	en_US
dc.title	Synthesis and biodistribution of 99mTc-PyDA as a potential marker for tumor hypoxia imaging	en_US
dc.type	Article	en_US

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