Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMahmoud W.R.
dc.contributor.authorNissan Y.M.
dc.contributor.authorElsawah M.M.
dc.contributor.authorRefaey R.H.
dc.contributor.authorRagab M.F.
dc.contributor.authorAmin K.M.
dc.contributor.otherPharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr Elini St
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Drug Research Center
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmacology and Toxicology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:31Z
dc.date.available2020-01-09T20:40:31Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractTwenty four 6-aminocoumarin based derivatives were synthesized according to two schemes. All the compounds were screened for their acetylcholinesterase inhibitory activity where compound 5b proved to be the most potent AChE inhibitor with (IC50 = 37 nM) compared to tacrine and donepezil (IC50 = 55.0 and 59.0 nM, respectively). Six compounds 2f, 2g, 4b, 5b, 8b and 9b revealed superior activity over donepezil and a conclusive structure activity relationship study was conducted explaining the obtained results. Furthermore, compounds 2f, 4b and 5b were investigated for their neurobehavioral effect in vivo. All the tested compounds showed improvement of neurobehavioral experiments using donepezil as reference drug. In addition, compounds 2f, 4b and 5b were able to reduce extracellular deposition of amyloid beta 42 in a comparable manner to donepezil. The binding modes of the synthesized compounds were evaluated in silico via molecular docking in the active site of AChE, as well as molecular dynamics simulation study. A pharmacophore model was generated for the newly synthesized compounds. � 2019 Elsevier Masson SASen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=17464&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.ejmech.2019.111651
dc.identifier.doiPubMed ID 31479975
dc.identifier.issn2235234
dc.identifier.otherhttps://doi.org/10.1016/j.ejmech.2019.111651
dc.identifier.otherPubMed ID 31479975
dc.identifier.urihttps://t.ly/LXMJA
dc.language.isoEnglishen_US
dc.publisherElsevier Masson SASen_US
dc.relation.ispartofseriesEuropean Journal of Medicinal Chemistry
dc.relation.ispartofseries182
dc.subjectAcetylcholinesterase inhibitorsen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectCoumarin derivativesen_US
dc.subject2 (4 fluorophenyl) 3 (2 oxo 2h chromen 6 yl)thiazolidin 4 oneen_US
dc.subject2 (4 methoxyphenyl) 3 (2 oxo 2h chromen 6 yl)thiazolidin 4 oneen_US
dc.subject2 [(2 oxo 2h chromen 6 yl)amino] n phenylacetamideen_US
dc.subject2 [4 (methylthio)phenyl] 3 (2 oxo 2h chromen 6 yl)thiazolidin 4 oneen_US
dc.subject5 (4 bromrobenzylidene) 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject5 (4 chlorobenzylidene) 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject5 (4 fluorobenzylidene) 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject5 (4 methoxybenzylidene) 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject5 benzylidene 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject5 [4 (dimethylamino)benzylidene] 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject5 [4 (methylthio)benzylidene] 2 [(2 oxo 2h chromen 6 yl)imino]thiazolidin 4 oneen_US
dc.subject6 (benzylideneamino) 2h chromen 2 oneen_US
dc.subject6 [(2 morpholino 2 oxoethyl)amino] 2h chromen 2 oneen_US
dc.subject6 [(2 oxo 2 phenylethyl)amino] 2h chromen 2 oneen_US
dc.subject6 [(4 bromobenzylidene)amino] 2h chromen 2 oneen_US
dc.subject6 [(4 chlorobenzylidene)amino] 2h chromen 2 onen_US
dc.subject6 [(4 flurobenzylidene)amino] 2h chromen 2 oneen_US
dc.subject6 [(4 methoxybenzylidene)amino] 2h chromen 2 oneen_US
dc.subject6 [[2 (4 methoxyphenyl) 2 oxo ethyl]amino) 2h chromen 2 oneen_US
dc.subject6 [[2 oxo 2 (4 phenylpiperazin 1 yl)ethyl]amino] 2h chromen 2 oneen_US
dc.subject6 [[4 (dimethylamino)benzylidene]amino] 2h chromen 2 oneen_US
dc.subject6 [[4 (methylthio)benzylidene]amino] 2h chromen 2 oneen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectcholinesterase inhibitoren_US
dc.subjectcoumarin derivativeen_US
dc.subjectdonepezilen_US
dc.subjectn (4 fluorophenyl) 2 [(2 oxo 2h chromen 6 yl)amino]acetamideen_US
dc.subjectn (4 methoxyphenyl) 2 [(2 oxo 2h chromen 6 yl)amino]acetamideen_US
dc.subjectnootropic agenten_US
dc.subjecttacrineen_US
dc.subjectunclassified drugen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectcholinesterase inhibitoren_US
dc.subjectcoumarin derivativeen_US
dc.subjectadulten_US
dc.subjectAlzheimer diseaseen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectcognitionen_US
dc.subjectcomputer modelen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug synthesisen_US
dc.subjectenzyme activityen_US
dc.subjectenzyme inhibitionen_US
dc.subjectescape latencyen_US
dc.subjectIC50en_US
dc.subjectin vivo studyen_US
dc.subjectmaleen_US
dc.subjectmemory consolidationen_US
dc.subjectmolecular dockingen_US
dc.subjectmolecular dynamicsen_US
dc.subjectMorris water maze testen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectnovel object recognition testen_US
dc.subjectpharmacophoreen_US
dc.subjectspatial memoryen_US
dc.subjectstructure activity relationen_US
dc.subjectY-maze testen_US
dc.subjectanimalen_US
dc.subjectchemical structureen_US
dc.subjectchemistryen_US
dc.subjectdose responseen_US
dc.subjectmetabolismen_US
dc.subjectsynthesisen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAnimalsen_US
dc.subjectCholinesterase Inhibitorsen_US
dc.subjectCoumarinsen_US
dc.subjectDose-Response Relationship, Drugen_US
dc.subjectMaleen_US
dc.subjectMiceen_US
dc.subjectMolecular Docking Simulationen_US
dc.subjectMolecular Structureen_US
dc.subjectStructure-Activity Relationshipen_US
dc.titleNeurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivativesen_US
dc.typeArticleen_US
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