Mucoadhesive Nanoparticles as Carrier Systems for Prolonged Ocular Delivery of Gatifloxacin/Prednisolone Bitherapy

dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorKamal Ibrahim, Howida
dc.contributor.authorSadar El-Leithy, Iman
dc.contributor.authorAwad Makky, Amna
dc.date.accessioned2020-03-24T06:29:11Z
dc.date.available2020-03-24T06:29:11Z
dc.date.issued2010
dc.descriptionMSA Google Scholaren_US
dc.description.abstractA fluoroquinolone/glucocorticoid combination for the treatment of bacterial keratitis in the form of mucoadhesive nanoparticle suspensions was developed to prolong the release and improve patient compliance. Gatifloxacin/prednisolone loaded nanoparticles were prepared using Eudragit RS 100 and RL 100 and coated with the bioadhesive polymer, hyaluronic acid. FT-IR and DSC studies revealed no interaction between gatifloxacin and prednisolone. The effects of the drug:polymer ratio (D:P) and the RS/RL ratio were studied. The obtained nanoparticles were distinct and spherical with a solid dense structure. They have average particle size range of 315.2 to 973.65 nm. Increasing the D:P ratio significantly lowered the entrapment efficiency for both drugs (p < 0.05). The nanoparticle suspensions revealed significantly prolonged drug release comparing to the free drugs (p < 0.05) with no burst effect. Increasing the polymer concentration and the Eudragit RS ratio significantly decreased the release efficiency values. Gatifloxacin showed anomalous release (n = 0.4943) from 1:1 D:P ratio nanoparticle suspension and Fickian diffusion mechanism (n < 0.45) from formulas prepared at higher D:P ratios. Gatifloxacin showed better bioavailability and sustained action in aqueous humor and corneal tissue from the nanoparticles compared to the commercial eye drops. The resulting nanoparticle suspension is promising in reducing dose frequency and improving patient compliance.en_US
dc.description.sponsorshipAmerican Chemical Societyen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=130126&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1021/mp900279c
dc.identifier.issn1543-8384
dc.identifier.otherhttps://doi.org/10.1021/mp900279c
dc.identifier.urihttps://cutt.ly/ZtbhRZC
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofseriesMolecular pharmaceutics;VOL : 7 Isssue : 2
dc.subjectMucoadhesiveen_US
dc.subjectnanoparticle suspensionsen_US
dc.subjectEudragiten_US
dc.subjectbacterial keratitisen_US
dc.subjectgatifloxacinen_US
dc.subjectprednisoloneen_US
dc.titleMucoadhesive Nanoparticles as Carrier Systems for Prolonged Ocular Delivery of Gatifloxacin/Prednisolone Bitherapyen_US
dc.typeArticleen_US

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