Hypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in rats

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Borady, O.M
dc.contributor.authorOthman, M.S
dc.contributor.authorAtallah, H.H
dc.contributor.authorAbdel Moneim, A.E
dc.date.accessioned2020-06-02T16:38:49Z
dc.date.available2020-06-02T16:38:49Z
dc.date.issued5/19/2020
dc.descriptionSCOPUSen_US
dc.description.abstractThis study was aimed to evaluate the efficacy of synthesized selenium nanoparticles (SeNPs) capped with glucose and polyvinyl-pyrrolidone (PVP) on the hyperglycemia and prooxidants/antioxidants imbalance present in model streptozotocin (STZ)-induced diabetic rats. SeNPs were synthesized and characterized. Twenty-four albino male rats were grouped into four different groups. After the rats were induced to have type 2 diabetes by STZ, the SeNPs-treated groups received a dose of 0.5 mg/ml of SeNPs for seven days. Plasma glucose and insulin levels, pancreatic insulin expression, the levels of lipid peroxidation (LPO), nitric oxide (NO), glutathione peroxidase (GPx) and glutathione (GSH) were evaluated. TEM images revealed the formation of semispherical particles with average size between 40 and 50 nm. SeNPs administration successfully reduced the hyperglycemia, raised the levels of insulin in both the pancreas and the plasma and restored the damaged pancreatic tissue. SeNPs also showed enhancement of the elimination of the diabetes-induced oxidative stress injuries by decreasing the pancreatic LPO and NO levels. Furthermore, the activities of the antioxidant enzyme GPx and GSH levels of the diabetic rats were increased. In conclusion, SeNPs capped with PVP could be used in the future as an agent that could manage Diabetes mellitus.en_US
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dc.identifier.doihttps://doi.org/10.1016/j.heliyon.2020.e04045
dc.identifier.issn24058440
dc.identifier.otherhttps://doi.org/10.1016/j.heliyon.2020.e04045
dc.identifier.urihttps://t.ly/emLI
dc.language.isoenen_US
dc.publisherELSEVIER LTDen_US
dc.relation.ispartofseriesHeliyon;Volume 6, Issue 5, May 2020, Article number e04045
dc.subjectUniversity for Biochemistryen_US
dc.subjectDiabetesen_US
dc.subjectSeleniumen_US
dc.subjectNanoparticlesen_US
dc.subjectPolyvinyl-pyrrolidoneen_US
dc.subjectHyperglycemiaen_US
dc.subjectOxidative stressen_US
dc.subjectHyperglycemiaen_US
dc.subjectStreptozotocinen_US
dc.subjectMaterials scienceen_US
dc.subjectChemistryen_US
dc.subjectBiological sciencesen_US
dc.subjectVeterinary medicineen_US
dc.subjectHealth sciencesen_US
dc.titleHypoglycemic potential of selenium nanoparticles capped with polyvinyl-pyrrolidone in streptozotocin-induced experimental diabetes in ratsen_US
dc.typeArticleen_US

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