Antidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic rats

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorM Abdallah, Hossam
dc.contributor.authorM Salama, Maha
dc.contributor.authorH Abd-Elrahman, Enas
dc.contributor.authorA El-Maraghy, Shohda
dc.date.accessioned2020-03-02T09:33:51Z
dc.date.available2020-03-02T09:33:51Z
dc.date.issued2011
dc.descriptionMSA Google Scholaren_US
dc.description.abstractThe n-butanol fraction (BF) of bark of Pecan tree, Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3′ sulfate (6) and caryatin-3′ methyl ether-7-O-β-d-glucoside (7) while five known phenolics (1–5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozocin diabetic rats. All the isolated compounds showed significant hypoglycaemic and antioxidant activities, except 5 and 6. A marked AR-inhibitory effect was identified for compounds 2, 3 and 7.en_US
dc.description.sponsorshipElseviren_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=11300153405&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.phytol.2011.07.004
dc.identifier.issn1874-3900
dc.identifier.otherhttps://doi.org/10.1016/j.phytol.2011.07.004
dc.identifier.urihttps://cutt.ly/CtqiGIJ
dc.language.isoenen_US
dc.publisherElseiveren_US
dc.relation.ispartofseriesPhytochemistry Letters;VOL : 4 Issue : 3
dc.subjectPecan barken_US
dc.subjectAldose reductaseen_US
dc.subjectMethoxy flavonoidsen_US
dc.subjectSulphated flavonoidsen_US
dc.subjectAntidiabeticen_US
dc.titleAntidiabetic activity of phenolic compounds from Pecan bark in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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