Antioxidant and apoptotic effects of caffeic acid phenethyl ester induced marked inhibition on human breast cancer cell line

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Refaei M.F.
dc.contributor.authorEl-Naa M.M.
dc.contributor.otherDepartment of Molecular Biology
dc.contributor.otherGenetic Engineering and Biotechnology Institute
dc.contributor.otherMenoufiya University
dc.contributor.otherEgypt; Department of Pharmacology and Toxicology
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:32Z
dc.date.available2020-01-25T19:58:32Z
dc.date.issued2011
dc.descriptionScopus
dc.description.abstractCancer is a disease that is marked by high cell proliferation and metastasis which remains incurable even now. The present study aims at investigating the anti-proliferative and apoptotic effects of Caffeic Acid Phenethyl Ester (CAPE) against human carcinogenesis. This fact was established in vitro by our assessment of a ZR-75-1 human breast cancer cell line. Present data showed that 15 ?M CAPE induced a significant inhibition of cell viability after 48 h (nearly 50%). Cell death was characterized by morphology and chromatin condensation changes, of a typical apoptosis. Moreover, there was a scavenging reduction activity in vitro towards both nitric oxide (>47%) and superoxide dismutase reduction (169.3�3.7 ?U L-1). In addition, malondialdehyde was non significantly inhibited compared with untreated tumor cells. The CAPE has significant inhibitory and anti-proliferative effects on tumor cancer cells in vitro. This inhibition may be related to its antioxidant effects and achieved throughout its apoptotic effect. These findings provide the possibility for the future use of CAPE in human clinical trials therapy. � 2011 Academic Journals Inc.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=11300153309&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.3923/ajb.2011.82.89
dc.identifier.doiPubMed ID :
dc.identifier.issn18159923
dc.identifier.otherhttps://doi.org/10.3923/ajb.2011.82.89
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/py8q9
dc.language.isoEnglishen_US
dc.relation.ispartofseriesAsian Journal of Biochemistry
dc.relation.ispartofseries6
dc.subjectAnti-proliferativeen_US
dc.subjectAnti-tumoren_US
dc.subjectAntioxidant enzymesen_US
dc.subjectApoptosisen_US
dc.titleAntioxidant and apoptotic effects of caffeic acid phenethyl ester induced marked inhibition on human breast cancer cell lineen_US
dc.typeArticleen_US
dcterms.isReferencedByAbdel-Latif, M., Wmdle, H., El-Homasany, B., Sabra, K., Kelleher, D., Caffeic acid phenethyl ester modulates Helicobacter pylori-induced nuclear factor-kappa B and activator protein-1 expression in gastric epithelial cells (2005) Br. J. Pharmacol, 146, pp. 1139-1147; Aso, K., Kanno, S., Tadano, T., Satoh, S., Ishikawa, M., Inhibitory effect of propolis on the growth of human leukemia U937 (2004) Biol. Pharm. Bull, 27, pp. 727-730; Cavaliere, V., Papademetrio, D.L., Lorenzetti, M., Valva, P., Preciado, M., Caffeic acid phenylethyl ester and MG-132 have apoptotic and antiproliferative effects on leukemic cells but not on normal mononuclear cells (2009) Transl. Oncol, 2, pp. 46-58; Chen, M.F., Keng, P.C., Lin, P.Y., Yang, C.T., Liao, S.K., Chen, W.C., Caffeic acid phenethyl ester decreases acute pneumonitis after irradiation in vitro and in vivo (2005) BMC Cancer, 5, pp. 1-9; Chen, M.J., Chang, W.H., Lin, C.C., Liu, C.Y., Wang, T.E., Caffeic acid phenethyl ester induces apoptosis of human pancreatic cancer cells involving caspase and mitochondrial dysfunction (2008) Pancreatology, 8, pp. 566-576; Engel, L., Young, N., Human breast carcinoma cells in continuous culture: A review (1978) Cancer Res, 38, pp. 4327-4339; Esterbauer, H., Cheeseman, K.H., Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxnonenal (1990) Methods Enzymol, 186, pp. 407-421; Fidan, H., Sahin, O., Yavuz, Y., Kilbas, A., Cetinkaya, Z., Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats (2007) Crit. Care Med, 35, pp. 2822-2829; Hileman, E.A., Achanta, G., Huang, P., Superoxide dismutase: An emerging target for cancer therapeutics (2001) Expert Opin. Ther. Targets, 5, pp. 697-710; Hong-Fang, J., Xue-Juan, L., Hong-Yu, Z., Natural products and drug discovery (2009) EMBO Rep, 10, pp. 194-200; Hutchins, D., Steel, C., Regulation of ICAM-1 (CD54) expression in human breast cancer cell lines by interleukin 6 and fibroblast-derived factors (1994) Int. J. Cancer, 1, pp. 80-84; Ichikawa, H., Satoh, K., Tobe, T., Yasuda, I., Ushio, F., Free radical scavenging activity of propolis (2002) Redox Rep, 7, pp. 347-350; Jang, J.W., Kay, C.S., You, C.R., Kim, C.W., Bae, S.H., Simultaneous multitarget irradiation using helical tomotherapy for advanced hep atocellular carcinoma with multiple extrahepatic metastases (2009) Int. J. Radiat. Oncol. Biol. Phys, 74, pp. 412-418; Jung, W.K., Lee, D.Y., Choi, Y.H., Yea, S.S., Choi, I., Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma (2008) Life Sci, 82, pp. 797-805; Kane, A., Yang, I., Interferon-gamma in brain tumor immunotherapy (2010) Neurosurg. Clin. N. Am, 21, pp. 77-86; Kim, H., Lee, H.S., Chang, K.T., Ko, T.H., Baek, K.J., Kwon, N.S., Chloromethyl ketones block induction of nitric oxide synthase in murine macrophages by preventing activation of nuclear factor-kappa (1995) B. J. Immunol, 154, pp. 4741-4748; Kuo, H.C., Kuo, W.H., Lee, Y.J., Lm, W.L., Chou, F.P., Tseng, T.H., Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo (2006) Cancer Lett, 234, pp. 199-208; Lingwood, R.J., Boyle, P., Milburn, A., Ngoma, T., Arbuthnott, J., The challenge of cancer control in Africa (2008) Nat. Rev. Cancer, 8, pp. 398-403; Miranda, K.M., Espey, M.G., Wink, D.A., A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite (2001) Nitric Oxide Biol. Chem, 5, pp. 62-71; Motomura, M., Kwon, K., Suh, S., Leec, Y., Kimd, Y., Propolis induces cell cycle arrest and apoptosis in human leukemic U937 cells through Bcl-2/Bax regulation (2008) Environ. Toxicol. Pharmacol, 26, pp. 61-67; Murad, N.A., Harhansyah, Ngah, W.Z.W., Yusof, Y.A.M., Antiprohferative, antioxidant and apoptosis effects of Zingber officinal and 6-Gingerol on HepG2 cells (2007) Asian J. Biochem, 2, pp. 421-426; Park, J.H., Lee, J.K., Kim, H.S., Chung, S.T., Eom, J.H., Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice (2004) Int. Immunopharmacol, 4, pp. 429-436; Rigas, B., Novel agents for cancer prevention based on nitric oxide (2007) Biochem. Soc. Trans, 35, pp. 1364-1368; Scheller, S., Krol, W., Swiacik, J., Owczarek, S., Gabrys, J., Shani, J., Antitumoral property of ethanolic extract of propolis in mice-bearing Ehrlich carcinoma, as compared to bleomycin (1989) Z. Naturforsch. C, 44, pp. 1063-1065; Song, J.J., Cho, J.G., Hwang, S.J., Cho, C.G., Park, S.W., Chae, S.W., Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells (2008) Acta Otolaryngol, 128, pp. 1303-1307; Sun, Y., Oberley, L.W., Li, Y., A simple method for clinical assay of superoxide dismutase (1988) Clm. Chem, 34, pp. 497-500; Takebayashi, H., Oida, H., Fujisawa, K., Yamaguchi, M., Hikida, T., Hormone-induced apoptosis y Fas-nuclear receptor fusion proteins: Novel biological tools for controlling apoptosis in vivo (1996) Cancer Res, 56, pp. 4164-4170; Tseng, T.H., Lee, Y.J., Evaluation of natural and synthetic compounds from East Asiatic folk medicinal plants on the mediation of cancer (2006) Anticancer Agents Med. Chem, 6, pp. 347-365; Ukeda, H., Sarker, A., Kawana, D., Sawamura, M., Flow-injection assay of superoxide dismutase based on the reduction of highly water-soluble tetrazolium (1999) Anal. Sci, 15, pp. 353-357; Van't land, B., Bhjlevens, N., Marteijn, J., Timal, S., Donnelly, P., de Witte, T., Rabet, L., Role of curcumin and the inhibition of NF- B in the onset of chemotherapy-induced mucosal barrier injury (2004) Leukemia, 18, pp. 276-284
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