IL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in rats

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAborehab N.M.
dc.contributor.authorWaly N.E.
dc.contributor.otherDepartment of Biochemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA University)6th October Giza 12611
dc.contributor.otherEgypt; Department of Physiology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherHelwan University
dc.contributor.otherCairo
dc.contributor.other11795
dc.contributor.otherEgypt; Department of Medical Education
dc.contributor.otherCreighton School of Medicine
dc.contributor.otherOmaha
dc.contributor.otherNE zip 68175
dc.contributor.otherUnited States
dc.date.accessioned2020-01-09T20:40:43Z
dc.date.available2020-01-09T20:40:43Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractIn this study, we investigated possible hepato-protective effects of N. Sativa, P. Ginseng, and C. Sempervirens in Aflatoxin B1 (AFB-1) induced hepatocellular carcinoma rat model. Fifty-four male albino rats were randomly assigned to experimental groups. Alcoholic extracts of aforementioned herbs were administered orally for 28 days at different doses. IL-6, hs-CRP, MDA, SOD and NFE2L2 were determined using ELISA. Histopathological changes in treated groups were examined. Herbal treatment significantly reduced IL-6, hs-CRP, and MDA (P < 0.001) whereas it significantly increased SOD (p < 0.001). C. Sempervirens 600 and N. Sativa 1000 increased NFE2L2 level compared to P. Ginseng 500 group (P value<0.01). Histopathological evaluation of treated groups showed different grades of healing of the liver. This study confirms a beneficial hepatoprotective effect for aforementioned herbal extracts orally administered in rat model of AFB1 induced HCC. This effect is putatively mediated via modulation of inflammatory cytokines as well as amelioration of oxidative stress. � 2019en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100367469&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.toxrep.2019.05.008
dc.identifier.doiPubMed ID :
dc.identifier.issn22147500
dc.identifier.otherhttps://doi.org/10.1016/j.toxrep.2019.05.008
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/W536X
dc.language.isoEnglishen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofseriesToxicology Reports
dc.relation.ispartofseries6
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectMSA University
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectC. Sempervirensen_US
dc.subjectHCCen_US
dc.subjectIL-6en_US
dc.subjectN. Sativaen_US
dc.subjectNFE2L2en_US
dc.subjectP. Ginsengen_US
dc.subjectalanine aminotransferaseen_US
dc.subjectalpha fetoproteinen_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectC reactive proteinen_US
dc.subjectCupressus Sempervirens extracten_US
dc.subjectginseng extracten_US
dc.subjectinterleukin 6en_US
dc.subjectmalonaldehydeen_US
dc.subjectNigella sativa extracten_US
dc.subjectplant extracten_US
dc.subjectsilymarinen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectunclassified drugen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectblack cuminen_US
dc.subjectblood samplingen_US
dc.subjectcell transformationen_US
dc.subjectcontrolled studyen_US
dc.subjectCupressusen_US
dc.subjectcytokine productionen_US
dc.subjectDNA binding assayen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectexperimental hepatocellular carcinomaen_US
dc.subjectginsengen_US
dc.subjectherbal medicineen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectliver functionen_US
dc.subjectliver protectionen_US
dc.subjectliver tissueen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectpriority journalen_US
dc.subjectraten_US
dc.titleIL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in ratsen_US
dc.typeArticleen_US
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