Metabolomic profiling and biological investigation of Tabebuia Aurea (Silva Manso) leaves, family Bignoniaceae

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMahmoud B.K.
dc.contributor.authorHamed A.N.E.
dc.contributor.authorSamy M.N.
dc.contributor.authorAbdelmohsen U.R.
dc.contributor.authorAttia E.Z.
dc.contributor.authorFawzy M.A.
dc.contributor.authorRefaey R.H.
dc.contributor.authorSalem M.A.
dc.contributor.authorPimentel-Elardo S.M.
dc.contributor.authorNodwell J.R.
dc.contributor.authorDesoukey S.Y.
dc.contributor.authorKamel M.S.
dc.contributor.otherDepartment of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMinia University
dc.contributor.otherMinia
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherDeraya University
dc.contributor.otherNew Minia City
dc.contributor.otherEgypt; Departmentof Biochemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMinia University
dc.contributor.otherMinia
dc.contributor.otherEgypt; Department of Pharmaceutical Chemistry
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University of Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Biochemistry
dc.contributor.otherUniversity of Toronto
dc.contributor.otherToronto
dc.contributor.otherON
dc.contributor.otherCanada
dc.date.accessioned2020-01-09T20:40:44Z
dc.date.available2020-01-09T20:40:44Z
dc.date.issued2019
dc.descriptionScopus
dc.description.abstractBoth ethyl acetate and aqueous fractions of Tabebuia aurea leaves exhibited noteworthy antioxidant and nephroprotective activities against carbon tetrachloride (CCl4)-induced nephrotoxicity in rats, as evidenced by the remarkable improvements of renal serum biomarkers and histopathological features. Additionally, the ethyl acetate fraction displayed a prominent in vitro antitrypanosomal activity against Trypanosoma brucei; consequently, the leaves were subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, ten metabolites were characterized, mostly dominated by flavonoids. Interestingly, two identified constituents viz., 3,9,12,15-octadecatetraenoic acid (9) and 9,11,13-octadecatrienoic acid (10) are reported firstly herein from the genus Tabebuia. Furthermore, among the dereplicated constituents, rutin (5) and kaempferol 3-O-rutinoside (6) exhibited the highest docking scores as effective antitrypanosomal compounds. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24819&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1080/14786419.2019.1698571
dc.identifier.doiPubMed ID 31797686
dc.identifier.issn14786419
dc.identifier.otherhttps://doi.org/10.1080/14786419.2019.1698571
dc.identifier.otherPubMed ID 31797686
dc.identifier.urihttps://t.ly/7OGVA
dc.language.isoEnglishen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofseriesNatural Product Research
dc.subjectantioxidanten_US
dc.subjectantitrypanosomalen_US
dc.subjectBignonia aureaen_US
dc.subjectmetabolomic profilingen_US
dc.subjectnephroprotectiveen_US
dc.subjectTabebuia argenteaen_US
dc.subjectTabebuia aureaen_US
dc.titleMetabolomic profiling and biological investigation of Tabebuia Aurea (Silva Manso) leaves, family Bignoniaceaeen_US
dc.typeArticleen_US
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