Computation of geometric representation of novel spectrophotometric methods used for the analysis of minor components in pharmaceutical preparations

Loading...
Thumbnail Image

Date

2015

Journal Title

Journal ISSN

Volume Title

Type

Article

Publisher

Elsevier

Series Info

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
151

Abstract

Novel spectrophotometric methods were applied for the determination of the minor component tetryzoline HCl (TZH) in its ternary mixture with ofloxacin (OFX) and prednisolone acetate (PA) in the ratio of (1:5:7.5), and in its binary mixture with sodium cromoglicate (SCG) in the ratio of (1:80). The novel spectrophotometric methods determined the minor component (TZH) successfully in the two selected mixtures by computing the geometrical relationship of either standard addition or subtraction. The novel spectrophotometric methods are: geometrical amplitude modulation (GAM), geometrical induced amplitude modulation (GIAM), ratio H-point standard addition method (RHPSAM) and compensated area under the curve (CAUC). The proposed methods were successfully applied for the determination of the minor component TZH below its concentration range. The methods were validated as per ICH guidelines where accuracy, repeatability, inter-day precision and robustness were found to be within the acceptable limits. The results obtained from the proposed methods were statistically compared with official ones where no significant difference was observed. No difference was observed between the obtained results when compared to the reported HPLC method, which proved that the developed methods could be alternative to HPLC techniques in quality control laboratories. � 2015 Elsevier B.V. All rights reserved.

Description

Scopus
MSA Google Scholar

Keywords

Amplitude modulation, Area under the curve, H-point, Prednisolone acetate, Sodium cromoglicate, Tetryzoline, Amplitude modulation, Binary mixtures, Geometry, Mixtures, Modulation, Quality control, Sodium, Spectrophotometers, Volatile fatty acids, Area under the curves, H-point, Prednisolone, Sodium cromoglicate, Tetryzoline, Spectrophotometry, antiinfective agent, antiinflammatory agent, decongestive agent, drug, imidazole derivative, ofloxacin, prednisolone, prednisolone acetate, tetryzoline, analogs and derivatives, computer analysis, procedures, spectrophotometry, Anti-Bacterial Agents, Anti-Inflammatory Agents, Computing Methodologies, Imidazoles, Nasal Decongestants, Ofloxacin, Pharmaceutical Preparations, Prednisolone, Spectrophotometry

Citation

Full Text link