The reaction of beta-amino-alpha,gamma-dicyanocrotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohareb, Rafat M.
dc.contributor.authorEl-Sharkawy, Karam A.
dc.contributor.authorSherif, Sherif M.
dc.date.accessioned2019-12-28T10:35:46Z
dc.date.available2019-12-28T10:35:46Z
dc.date.issued2008
dc.descriptionAccession Number: WOS:000262205800006en_US
dc.description.abstractCondensation of beta-amino-alpha,gamma-dicyanocrotononitrile (1) with acetophenone gave 2-amino-4-phenylpenta-1,3-diene-1,1,3-tricarbonitrile (2). The latter product was used in a series of heterocyclization reactions with different reagents such as diazonium salts, hydrazines, hydroxylamines and elemental sulfur to give pyridazine, pyrazole, isoxazole and thiophene derivatives, respectively. On the other hand, it gave pyridine derivatives with aromatic aldehydes folowed by reaction with cyanomethylene reagents. The MIC values for the newly synthesized product were measured against E. coli, B. cereus, B. subtilis and C. albicans.en_US
dc.description.sponsorshipAlexander von Humboldt FoundationAlexander von Humboldt Foundationen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19398&tip=sid&clean=0
dc.identifier.citationCited References in Web of Science Core Collection: 21en_US
dc.identifier.doihttps://doi.org/10.2478/v10007-008-0030-3
dc.identifier.issn1330-0075
dc.identifier.otherhttps://doi.org/10.2478/v10007-008-0030-3
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/19103577
dc.language.isoenen_US
dc.publisherHRVATSKO FARMACEUTSKO DRUSTOV (HFD)-CROATION PHARMACEUTICAL SOC.en_US
dc.relation.ispartofseriesACTA PHARMACEUTICA;Volume: 58 Issue: 4 Pages: 429-444
dc.relation.urihttps://t.ly/1d3eA
dc.subjectUniversity of pyridine; isoxazole; pyridazine; thiophene; antimicrobial activityen_US
dc.subjectMOLLUSCICIDAL ACTIVITY; ANTITUMOR AGENTS; INHIBITORS; DISCOVERY; ANALOGS; POTENT; ACID; RINGen_US
dc.titleThe reaction of beta-amino-alpha,gamma-dicyanocrotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activitiesen_US
dc.typeArticleen_US

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