Spectrofluorimetric determination of certain biologically active phenothiazines in commercial dosage forms and human plasma

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohamed A.-M.I.
dc.contributor.authorAbdelmageed O.H.
dc.contributor.authorSalem H.
dc.contributor.authorNagy D.M.
dc.contributor.authorOmar M.A.
dc.contributor.otherPharmaceutical Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAssiut University
dc.contributor.otherAssiut
dc.contributor.otherEgypt; Pharmaceutical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherKing Abdulaziz University
dc.contributor.otherJeddah
dc.contributor.otherSaudi Arabia; Pharmaceutical Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMinia University
dc.contributor.otherMinia
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:24Z
dc.date.available2020-01-09T20:42:24Z
dc.date.issued2013
dc.descriptionScopus
dc.description.abstractA validated simple and sensitive spectrofluorimetric method was developed for the determination of chlorpromazine hydrochloride, promethazine hydrochloride, trifluperazine hydrochloride, thioridazine hydrochloride, perazine maleate and oxomemazine. The method was based on condensation of malonic acid/acetic anhydride (MAA) under the catalytic effect of the tertiary amine moiety of the studied phenothiazines to provide a deep yellow to brown colour with green florescence. Relative fluorescence intensity of the products was measured at ?exc 398 nm and ?em 432 nm. Different variables affecting the reaction were studied and optimized. The method was successfully applied for the determination of the studied drugs in commercial dosage forms. The lower detection limits allowed the application of this method for the determination of the compounds in plasma as an example of a biological fluid. In addition, the method was considered specific for the determination of tertiary amines in the presence of primary and secondary amines; as a result, it was deemed suitable for the determination of the cited drugs in the presence of their degradation products resulting from N-dealkylation or oxidation of the corresponding sulphoxides or sulphones. Copyright � 2012 John Wiley & Sons, Ltd.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26988&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1002/bio.2388
dc.identifier.doiPubMed ID 22786713
dc.identifier.issn15227235
dc.identifier.otherhttps://doi.org/10.1002/bio.2388
dc.identifier.otherPubMed ID 22786713
dc.identifier.urihttps://t.ly/BX3jM
dc.language.isoEnglishen_US
dc.relation.ispartofseriesLuminescence
dc.relation.ispartofseries28
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectacetic anhydrideen_US
dc.subjectdosage formsen_US
dc.subjectmalonic aciden_US
dc.subjectphenothiazinesen_US
dc.subjectplasmaen_US
dc.subjectspectrofluorimetric determinationen_US
dc.subjectdrug dosage formen_US
dc.subjectneuroleptic agenten_US
dc.subjectphenothiazine derivativeen_US
dc.subjectneuroleptic agenten_US
dc.subjectphenothiazine derivativeen_US
dc.subjectblooden_US
dc.subjectdrug dosage formen_US
dc.subjectevaluation studyen_US
dc.subjecthumanen_US
dc.subjectproceduresen_US
dc.subjectspectrofluorometryen_US
dc.subjectarticleen_US
dc.subjectmethodologyen_US
dc.subjectspectrofluorometryen_US
dc.subjectAntipsychotic Agentsen_US
dc.subjectDosage Formsen_US
dc.subjectHumansen_US
dc.subjectPhenothiazinesen_US
dc.subjectSpectrometry, Fluorescenceen_US
dc.subjectAntipsychotic Agentsen_US
dc.subjectDosage Formsen_US
dc.subjectHumansen_US
dc.subjectPhenothiazinesen_US
dc.subjectSpectrometry, Fluorescenceen_US
dc.titleSpectrofluorimetric determination of certain biologically active phenothiazines in commercial dosage forms and human plasmaen_US
dc.typeArticleen_US
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