Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity
Date
2016
Journal Title
Journal ISSN
Volume Title
Type
Review
Publisher
Wiley-VCH Verlag
Series Info
Archiv der Pharmazie
349
349
Scientific Journal Rankings
Abstract
Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date. � 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Description
Scopus
MSA Google Scholar
MSA Google Scholar
Keywords
Anticancer, Kinase inhibitors, Quinoxalines, SAR, Synthetic strategies, antineoplastic agent, cyclin dependent kinase 1, cyclin dependent kinase 2, cyclin dependent kinase 4, cyclin dependent kinase 6, doxorubicin, Janus kinase 2 inhibitor, protein kinase inhibitor, protein tyrosine kinase inhibitor, quinoxaline derivative, vasculotropin inhibitor, antineoplastic agent, protein kinase inhibitor, protein tyrosine kinase, quinoxaline derivative, antineoplastic activity, biological activity, drug cytotoxicity, drug synthesis, drug targeting, human, nonhuman, priority journal, Review, structure activity relation, antagonists and inhibitors, chemical structure, chemistry, molecular model, synthesis, Antineoplastic Agents, Humans, Models, Molecular, Molecular Structure, Protein Kinase Inhibitors, Protein-Tyrosine Kinases, Quinoxalines, Structure-Activity Relationship