Centaurea pumilio L. extract and nanoparticles: A candidate for healthy skin
dc.Affiliation | October University for modern sciences and Arts (MSA) | |
dc.contributor.author | Mostafa E. | |
dc.contributor.author | Fayed M.A.A. | |
dc.contributor.author | Radwan R.A. | |
dc.contributor.author | Bakr R.O. | |
dc.contributor.other | Department of Pharmacognosy | |
dc.contributor.other | Faculty of Pharmacy | |
dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
dc.contributor.other | Giza | |
dc.contributor.other | 11787 | |
dc.contributor.other | Egypt; Department of Pharmacognosy | |
dc.contributor.other | Faculty of Pharmacy | |
dc.contributor.other | University of Sadat City | |
dc.contributor.other | Egypt; Biochemistry and Biotechnology Department | |
dc.contributor.other | Faculty of Pharmacy & Drug Technology | |
dc.contributor.other | Heliopolis University | |
dc.contributor.other | Cairo | |
dc.contributor.other | Egypt | |
dc.date.accessioned | 2020-01-09T20:40:33Z | |
dc.date.available | 2020-01-09T20:40:33Z | |
dc.date.issued | 2019 | |
dc.description | Scopus | |
dc.description.abstract | Centaurea pumilio was the subject of phytochemical and biological studies, and its extract was used in the green synthesis of silver nanoparticles (AgNPs). Liquid chromatography/electrospray ionization mass spectrometry allowed the tentative identification of twenty-nine phytoconstituents of C. pumilio methanolic extract (CME), while column chromatography led to the identification of eight phenolic compounds. The neutral red uptake method showed the safety of CME and AgNPs on skin cells (HaCaT cell lines), while their high antioxidant potentials were demonstrated based on their oxygen radical absorbance capacity, and these results were confirmed in vivo. Additionally, CME and AgNPs had promising abilities to retard the ageing process and combat dark spots by potently inhibiting collagenase, elastase and tyrosinase, in addition to antimicrobial activity against skin infection-causing strains, especially Staphylococcus aureus, which was further confirmed by the significant phagocytic activity of neutrophils via engulfment. This study presents C. pumilio as a candidate for healthy skin. 2019 Elsevier B.V. | en_US |
dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=26590&tip=sid&clean=0 | |
dc.identifier.doi | https://doi.org/10.1016/j.colsurfb.2019.110350 | |
dc.identifier.doi | PubMed ID 31326622 | |
dc.identifier.issn | 9277765 | |
dc.identifier.other | https://doi.org/10.1016/j.colsurfb.2019.110350 | |
dc.identifier.other | PubMed ID 31326622 | |
dc.identifier.uri | https://t.ly/XAA01 | |
dc.language.iso | English | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartofseries | Colloids and Surfaces B: Biointerfaces | |
dc.relation.ispartofseries | 182 | |
dc.subject | Anti-ageing | en_US |
dc.subject | Centaurea | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Phenolics | en_US |
dc.subject | Bacteria | en_US |
dc.subject | Cell culture | en_US |
dc.subject | Ionization of liquids | en_US |
dc.subject | Liquid chromatography | en_US |
dc.subject | Mass spectrometry | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Silver nanoparticles | en_US |
dc.subject | Synthesis (chemical) | en_US |
dc.subject | Anti-ageing | en_US |
dc.subject | Anti-microbial activity | en_US |
dc.subject | Antioxidant potential | en_US |
dc.subject | Centaurea | en_US |
dc.subject | Ionization mass spectrometry | en_US |
dc.subject | Oxygen radical absorbance capacities | en_US |
dc.subject | Phenolics | en_US |
dc.subject | Silver nanoparticles (AgNps) | en_US |
dc.subject | Column chromatography | en_US |
dc.subject | antiinfective agent | en_US |
dc.subject | antioxidant | en_US |
dc.subject | Centaurea pumilio extract | en_US |
dc.subject | collagenase | en_US |
dc.subject | elastase | en_US |
dc.subject | ketoconazole | en_US |
dc.subject | monophenol monooxygenase | en_US |
dc.subject | plant extract | en_US |
dc.subject | silver nanoparticle | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | vancomycin | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal tissue | en_US |
dc.subject | antimicrobial activity | en_US |
dc.subject | antioxidant activity | en_US |
dc.subject | Article | en_US |
dc.subject | Candida albicans | en_US |
dc.subject | Centaurea | en_US |
dc.subject | Centaurea pumilio | en_US |
dc.subject | column chromatography | en_US |
dc.subject | cytotoxicity | en_US |
dc.subject | electrospray mass spectrometry | en_US |
dc.subject | Escherichia coli | en_US |
dc.subject | female | en_US |
dc.subject | HaCat cell line | en_US |
dc.subject | human | en_US |
dc.subject | IC50 | en_US |
dc.subject | in vivo study | en_US |
dc.subject | liquid chromatography-mass spectrometry | en_US |
dc.subject | nonhuman | en_US |
dc.subject | ORAC assay | en_US |
dc.subject | priority journal | en_US |
dc.subject | Pseudomonas aeruginosa | en_US |
dc.subject | rat | en_US |
dc.subject | Staphylococcus aureus | en_US |
dc.subject | Streptococcus pyogenes | en_US |
dc.subject | traditional medicine | en_US |
dc.title | Centaurea pumilio L. extract and nanoparticles: A candidate for healthy skin | en_US |
dc.type | Article | en_US |
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