Adaptation of hard gelatin capsules for oral delivery of aqueous radiopharmaceuticals

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorOmar S.M.
dc.contributor.authorAbdel-Rashid R.S.
dc.contributor.authorAlAssaly M.K.
dc.contributor.authorSakr T.M.
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAhram Canadian University
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherAin Helwan
dc.contributor.otherCairo
dc.contributor.other11795
dc.contributor.otherEgypt; Ministry of Interior
dc.contributor.otherMedical Services
dc.contributor.otherCairo
dc.contributor.otherEgypt; Faculty of Pharmacy
dc.contributor.otherOctober University of Modern Sciences and Arts
dc.contributor.otherCairo
dc.contributor.otherEgypt; Radioactive Isotopes and Generators
dc.contributor.otherAtomic Energy Authority
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:37Z
dc.date.available2020-01-09T20:40:37Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractPurpose: Oral administration of Iodine?131 (I?131) solutions causes high risk of contamination for patients and dispensers. The objective of the study was to adapt hard gelatin capsules (HGCs) for filling with radiopharmaceutical solutions without deformation. Methods: Polystyrene (PS) internally lining films with different thicknesses were used to protect HGCs. The insulated HGCs were evaluated for their physicochemical characteristics and rupturing time in different dissolution media. HGCs internally lined with PS were examined for withstand loading with different volumes and radioactivities of I?131 solutions. Radioactivity release was studied in deionized water and acidic media. Quality control of released I?131 was inspected for radiochemical purities. Results: There was a directly proportion between PS lining thickness and stability of HGCs after filling with 500�?l aqueous methylene blue solution. HGCs internally lined with PS 100�?m thickness withstand deformation for ? two months; however showed fast in-vitro rupturing time in different dissolution media. Internally lined HGCs loaded with different volumes and radioactivities of I?131 solutions resisted for one week without radioactive leakage. Yet, revealed complete release of I?131 after 20�min in dissolution media with great radiochemical purity. Conclusion: The study promises safely I?131 aqueous solution delivery via adapted HGCs. [Figure not available: see fulltext.]. � 2019, Springer Nature Switzerland AG.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=20710&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1007/s40199-019-00275-2
dc.identifier.doiPubMed ID 31175641
dc.identifier.issn15608115
dc.identifier.otherhttps://doi.org/10.1007/s40199-019-00275-2
dc.identifier.otherPubMed ID 31175641
dc.identifier.urihttps://t.ly/BXJjX
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.ispartofseriesDARU, Journal of Pharmaceutical Sciences
dc.relation.ispartofseries27
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectAdaptationen_US
dc.subjectHard gelatin capsulesen_US
dc.subjectIodine?131 solutionen_US
dc.subjectLiningen_US
dc.subjectPolystyreneen_US
dc.subjectdeionized wateren_US
dc.subjectgelatinen_US
dc.subjectiodine 131en_US
dc.subjectpolystyreneen_US
dc.subjectgelatinen_US
dc.subjectradioactive iodineen_US
dc.subjectradiopharmaceutical agenten_US
dc.subjectaqueous solutionen_US
dc.subjectArticleen_US
dc.subjectbiofilmen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug releaseen_US
dc.subjectdrug solubilityen_US
dc.subjectFourier transform infrared spectroscopyen_US
dc.subjectin vitro studyen_US
dc.subjectmass fragmentographyen_US
dc.subjectphysical chemistryen_US
dc.subjectquality controlen_US
dc.subjectradiation measurementen_US
dc.subjectradiation stabilityen_US
dc.subjectradioactivityen_US
dc.subjectradiochemistryen_US
dc.subjectsolubilityen_US
dc.subjectchemistryen_US
dc.subjectdrug formulationen_US
dc.subjecthumanen_US
dc.subjectmicrocapsuleen_US
dc.subjectoral drug administrationen_US
dc.subjectAdministration, Oralen_US
dc.subjectCapsulesen_US
dc.subjectDrug Compoundingen_US
dc.subjectGelatinen_US
dc.subjectHumansen_US
dc.subjectIodine Radioisotopesen_US
dc.subjectRadiopharmaceuticalsen_US
dc.titleAdaptation of hard gelatin capsules for oral delivery of aqueous radiopharmaceuticalsen_US
dc.typeArticleen_US
dcterms.isReferencedBySaha, G.B., (2010) Characteristics of specific radiopharmaceuticals (chap. 7). Fundamentals of Nuclear Pharmacy 6th ed, pp. 115-152. , Springer, New York; Santos-Oliveira, R., Antunes, L.J., Radiopharmaceutical research and production in Brazil: a 30-year history of participation in the nuclear medicine scenario (2011) J Nucl Med Technol, 39 (3), pp. 237-239; Garcia-Pe�a, E., Caravalho, J., Watkins, J.W., Leifer, E.S., Esophageal passage of iodine-131 capsules (1997) J Nucl Med Technol, 25 (1), pp. 55-58; Kristensen, K., N�rbygaard, E., Safety and efficacy of radiopharmaceuticals Springer Science & Business Media, 2012, pp. 85-98. , editors, 4. 1984th ed: pub; Hung, J.C., Radioiodine dispensing and usage in a centralized hospital nuclear pharmacy (1997) Thyroid., 7 (2), pp. 289-294; Kamalakkannan, V., Puratchikody, A., Masilamani, K., Senthilnathan, B., Solubility enhancement of poorly soluble drugs by solid dispersion technique�a review (2010) J Pharm Res, 3 (9), pp. 2314-2321; Marques, M.R., Cole, E., Kruep, D., Gray, V., Murachanian, D., Brown, W.E., (2009) Liquid-Filled Gelatin Capsules. Pharmacopeial Forum; Kuentz, M., R�thlisberger, D., Determination of the optimal amount of water in liquid-fill masses for hard gelatin capsules by means of texture analysis and experimental design (2002) Int J Pharm, 236 (1), pp. 145-152; Howard, S.S., Alexander, S., (1964) Capsule containing a pharmaceutically useful radioactive material. U.S. patent no. 3,121,041, , U.S. Patent and Trademark Office, Washington, DC; Takada, K., Murakami, M., (2005) Glycyrrhizin preparations for transmucosal absorption. U.S. patent no. 6,890, 547. , U.S. Patent and Trademark Office, Washington, DC; El-Aasser, M.S., Fitch, R.M., (2012) Future Directions in Polymer Colloids: Springer Science & Business Media, p. 138; Sterns, R.H., Rojas, M., Bernstein, P., Chennupati, S., Ion-exchange resins for the treatment of hyperkalemia: are they safe and effective? (2010) J Am Soc Nephrol, 21 (5), pp. 733-735; Iconomopoulou, S., Andreopoulou, A., Soto, A., Kallitsis, J., Voyiatzis, G., Incorporation of low molecular weight biocides into polystyrene�divinyl benzene beads with controlled release characteristics (2005) J Control Release, 102 (1), pp. 223-233; Patil, P., Paradkar, A., Porous polystyrene beads as carriers for self-emulsifying system containing loratadine (2006) AAPS PharmSciTech, 7 (1), pp. E199-E205; Maria, A.V.W., Margarida, M.C.O., Marcela, Z., Ariane, J.S.B., Mohammed, Q., Ralph, S.O., Nanoradiopharmaceuticals for nanomedicine: building the future (2014) Recent Pat Nanomed, 4 (2), pp. 90-94; Sanagi, M.M., Lu, L.S., Nasir, Z., Ibrahim, W.A.W., Ahmedy, A.N., Determination of residual volatile organic compounds migrated from polystyrene food packaging into food simulant by headspace solid phase micro extraction-gas chromatography (2008) Malaysian Journal of Analytical Sciences, 12 (3), pp. 542-551; Rosell, M., Ginebreda, A., Barcel�, D., Simultaneous determination of methyl tert.-butyl ether and its degradation products, other gasoline oxygenates and benzene, toluene, ethylbenzene and xylenes in Catalonian groundwater by purge-and-trap-gas chromatography�mass spectrometry (2003) J Chromatogr A, 995 (1), pp. 171-184; Perkasa, D.P., Erizal, E., Darmawan, D., Rasyid, A., Effect of gamma irradiation on mechanical and thermal properties of fish gelatin film isolated from lates calcarifer scales (2013) Indonesian Journal of Chemistry, 13 (1), pp. 28-35; Cilurzo, F., Selmin, F., Minghetti, P., Montanari, L., Lenardi, C., Orsini, F., Poletti, G., Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules (2005) AAPS PharmSciTech, 6 (4), pp. E586-E593; Rockville, M., Disintegration and dissolution of dietary supplements h2040i, pp. 732-736. , USP USP 31�NF 262008; (2003) Manual for reactor produced radioisotope, , International Atomic Energy Agency, Vienna; (2008), 2 (3), pp. 422-426. , Roydan. United States pharmacopeia (USP 32) and the 27th edition of the national formulary (NF 27). Rockville: The United States Pharmacopeial Convention. Pustaka Kesehatan; Socrates, G., Six membered ring heterocyclic compounds In: Infrared and Raman Characteristic Group Frequencies: Tables and Charts 3Rd Ed: Wiley, 2001, p. 171; Ofner, C.M., Zhang, Y.E., Jobeck, V.C., Bowman, B.J., Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity (2001) J Pharm Sci, 90 (1), pp. 79-88; Suriyanarayanan, S., Cywinski, P.J., Moro, A.J., Mohr, G.J., Kutner, W., (2012) Chemosensors Based on Molecularly Imprinted Polymers, p. 325. , Haupt K, molecular imprinting Top Curr Chem, Springer Science & Business Media; Shepson, P., Edney, E., Corse, E., Ring fragmentation reactions in the photooxidations of toluene and o-xylene (1984) J Phys Chem, 88 (18), pp. 4122-4126; Digenis, G.A., Gold, T.B., Shah, V.P., Cross-linking of gelatin capsules and its relevance to their in vitro-in vivo performance (1994) J Pharm Sci, 83 (7), pp. 915-921; Ellis, B., Smith, R., Oriented polystyrene sheet and film (2008) Polymers: A Property Database, pp. 327-328. , 2nd Ed, CRC Press, Taylor & Francis Group; Bullwinkel, M., Gu, J., Campbell, G., Sukanek, P., The effect of polymer molecular weight and solvent type on the planarization of spin-coated films (1995) J Electrochem Soc, 142 (7), pp. 2389-2394; Islam, M.M., Zaman, A., Islam, M.S., Khan, M.A., Rahman, M.M., Physico-chemical characteristics of gamma-irradiated gelatin (2014) Prog Biomater, 3 (1), p. 21; Chiwele, I., Jones, B.E., Podczeck, F., The shell dissolution of various empty hard capsules (2000) Chem Pharm Bull, 48 (7), pp. 951-956; Zhang, X., Do, M.D., Casey, P., Sulistio, A., Qiao, G.G., Lundin, L., Lillford, P., Kosaraju, S., Chemical cross-linking gelatin with natural phenolic compounds as studied by high-resolution NMR spectroscopy (2010) Biomacromolecules., 11 (4), pp. 1125-1132; Mercade-Prieto, R., Sahoo, P.K., Falconer, R.J., Paterson, W.R., Wilson, D.I., Polyelectrolyte screening effects on the dissolution of whey protein gels at high pH conditions (2007) Food Hydrocoll, 21 (8), pp. 1275-1284; Duconseille, A., Astruc, T., Quintana, N., Meersman, F., Sante-Lhoutellier, V., Gelatin structure and composition linked to hard capsule dissolution: a review (2015) Food Hydrocoll, 43, pp. 360-376; Yang, X.J., Zheng, P.J., Cui, Z.D., Zhao, N.Q., Wang, Y.F., De Yao, K., Swelling behaviour and elastic properties of gelatin gels (1997) Polym Int, 44 (4), pp. 448-452; Miyawaki, O., Norimatsu, Y., Kumagai, H., Irimoto, Y., Kumagai, H., Sakurai, H., Effect of water potential on sol-gel transition and intermolecular interaction of gelatin near the transition temperature (2003) Biopolymers., 70 (4), pp. 482-491; Swidan, M., Sakr, T., Motaleb, M., El-Bary, A.A., El-Kolaly, M., Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging (2015) J Radioanal Nucl Chem, 303 (1), pp. 531-539; Swidan, M., Sakr, T., Motaleb, M., El-Bary, A.A., El-Kolaly, M., Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging (2014) J Label Compd Radiopharm, 57 (10), pp. 593-599
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