Ion selective membrane electrodes for determination of Citalopram Hydrobromide in drug product and in presence of its degradation products

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorNebsen M.
dc.contributor.authorEl-Maraghy C.M.
dc.contributor.authorSalem H.
dc.contributor.authorAmer S.M.
dc.contributor.otherAnalytical Chemistry department
dc.contributor.otherCairo University
dc.contributor.otherKasr-El Aini Street
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Pharmaceutical Analytical Chemistry department
dc.contributor.otherHeliopolis University
dc.contributor.other3 Cairo Belbeis desert road
dc.contributor.otherEl-Horria
dc.contributor.otherCairo
dc.contributor.other2834
dc.contributor.otherEgypt; Analytical Chemistry department
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.other6th October city
dc.contributor.other11787
dc.contributor.otherEgypt; Pharmaceutical Analytical Chemistry department
dc.contributor.otherDeraya University
dc.contributor.otherMinia
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:47Z
dc.date.available2020-01-09T20:41:47Z
dc.date.issued2015
dc.descriptionScopus
dc.description.abstractThis paper presents a comparative study between three sensors developed to determine Citalopram Hydrobromide (CT) in the presence of its alkaline hydrolysis and oxidation induced degradation products using different ion association complexes. Sensor 1 was fabricated using phosphomolybdic acid, Sensor 2 used phosphotungestic acid and sensor 3 used the sodium tetraphenyl borate. Linear responses of CT were obtained within the concentration ranges of 1�10?6 to 1�10?2 mol L-1 for sensor 1 and 2 and 1�10?5 to 1�10?2 mol L-1 for sensor 3 over the pH range of 3.0�6.0. The selectivity coefficients of the developed sensors indicated excellent selectivity for CT. The proposed sensors displayed useful analytical characteristics for the determination of CT in bulk powder, pharmaceutical formulation, and in the presence of its degradation products and thus could be used for stability-indicating methods. The method was validated according to ICH guidelines. Statistical comparison between the results from the proposed method and the results from the reference HPLC method showed no significant difference regarding accuracy and precision. � 2015 by CEE (Center of Excellence in Electrochemistry).en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100224440&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn20084226
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/5x6eY
dc.language.isoEnglishen_US
dc.publisherCenter of Excellence in Electrochemistry, Univ. of Tehranen_US
dc.relation.ispartofseriesAnalytical and Bioanalytical Electrochemistry
dc.relation.ispartofseries7
dc.subjectCation exchangeren_US
dc.subjectCitalopram Hydrobromideen_US
dc.subjectDegradation productsen_US
dc.subjectIon selective electrodeen_US
dc.subjectPVCen_US
dc.titleIon selective membrane electrodes for determination of Citalopram Hydrobromide in drug product and in presence of its degradation productsen_US
dc.typeArticleen_US
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