Osteopontin expression in chronic plaque psoriasis: An association with the severity of disease

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAbdou A.G.
dc.contributor.authorEl Farargy S.
dc.contributor.authorSeleit I.
dc.contributor.authorAntar A.G.
dc.contributor.authorElhefny M.
dc.contributor.authorElnaidany N.F.
dc.contributor.otherDepartment of Pathology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenofiya University
dc.contributor.otherShebein Elkom
dc.contributor.otherEgypt; Department of Dermatology and Andrology
dc.contributor.otherFaculty of Medicine
dc.contributor.otherMenofiya University
dc.contributor.otherShebein Elkom
dc.contributor.otherEgypt; Department of Clinical Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherModern Sciences and Arts University
dc.contributor.otherOctober City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:28Z
dc.date.available2020-01-25T19:58:28Z
dc.date.issued2012
dc.descriptionScopus
dc.description.abstractObjective: To explore the possible role of osteopontin (OPN) in chronic plaque psoriasis and understand the role of inflammation in psoriasis. STUDY DESIGN: We investigated 36 patients with chronic plaque psoriasis using immunohistochemical technique for evaluation of OPN immunolocalization compared to normal skin biopsies of 10 normal subjects representing the control group. Results: OPN was expressed in the epidermis of all specimens, both in the psoriasis group and the control group without any significant differences except for the tendency of psoriatic lesions to show more cytoplasmic and nuclear pattern of OPN staining (55.56%) compared to normal skin (20%). Epidermal strong and diffuse immunostaining of OPN was associated with the severity of psoriasis, and there was a correlation of the intensity of OPN expression with the density of the dermal inflammatory infiltrate. Conclusion: Our study suggests that OPN is involved in the pathophysiology of psoriasis, and a possible association with disease severity. OPN acts by different mechanisms through its expression by lesional keratinocytes, inflammatory cells, and endothelial cells. Nuclear localization of OPN may have a more significant role in the pathogenesis of psoriasis. � Science Printers and Publishers, Inc.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=18392&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn8846812
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/dOgyL
dc.language.isoEnglishen_US
dc.relation.ispartofseriesAnalytical and Quantitative Cytology and Histology
dc.relation.ispartofseries34
dc.subjectInflammationen_US
dc.subjectOsteopontinen_US
dc.subjectPsoriasisen_US
dc.subjectosteopontinen_US
dc.subjectadulten_US
dc.subjectarticleen_US
dc.subjectcell nucleusen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectcorrelation analysisen_US
dc.subjectcytoplasmen_US
dc.subjectdisease associationen_US
dc.subjectdisease severityen_US
dc.subjectendothelium cellen_US
dc.subjectepidermisen_US
dc.subjectfemaleen_US
dc.subjecthair follicleen_US
dc.subjecthumanen_US
dc.subjectimmunohistochemistryen_US
dc.subjectimmunolocalizationen_US
dc.subjectinflammatory cellen_US
dc.subjectinflammatory infiltrateen_US
dc.subjectkeratinocyteen_US
dc.subjectmaleen_US
dc.subjectpathogenesisen_US
dc.subjectpathophysiologyen_US
dc.subjectpriority journalen_US
dc.subjectprotein expressionen_US
dc.subjectprotein localizationen_US
dc.subjectpsoriasis vulgarisen_US
dc.subjectPUVAen_US
dc.subjectsebaceous glanden_US
dc.subjectskin biopsyen_US
dc.subjectsweat glanden_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectBiopsyen_US
dc.subjectChilden_US
dc.subjectChronic Diseaseen_US
dc.subjectDermatitisen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectImmunohistochemistryen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectOsteopontinen_US
dc.subjectPsoriasisen_US
dc.subjectSeverity of Illness Indexen_US
dc.subjectYoung Adulten_US
dc.titleOsteopontin expression in chronic plaque psoriasis: An association with the severity of diseaseen_US
dc.typeArticleen_US
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