Insulin Mucoadhesive Liposomal Gel for Wound Healing: a Formulation with Sustained Release and Extended Stability Using Quality by Design Approach

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorDawoud M.H.S.
dc.contributor.authorYassin G.E.
dc.contributor.authorGhorab D.M.
dc.contributor.authorMorsi N.M.
dc.contributor.otherDepartment of Pharmaceutics
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.other(MSA University)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Department of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAl-Azhar University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Department of Pharmaceutics and Industrial Pharmacy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:38Z
dc.date.available2020-01-09T20:40:38Z
dc.date.issued2019
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe present study deals with the formulation of topical insulin for wound healing with extended stability and sustained release, by applying quality by design concepts. Insulin has been promoted as a promising therapeutic wound healing agent. Topical formulation of insulin faced major problems, as it cannot be delivered safely to the wound with a controlled rate. Formulation of insulin-loaded vesicles in optimized bio-adhesive hydrogels has been explored to ensure a safe delivery of insulin to wounds in a controlled manner. Quality by design (QbD) was applied to study the effect of several critical process parameters on the critical quality attributes. Ishikawa diagram was used to identify the highest risk factors, which were screened by a fractional factorial design and augmented by Box�Behnken design. The optimized formula was incorporated into a mucoadhesive gel, which was further subjected to stability and clinical studies. An optimized formula was obtained with a particle size of 257.751�nm, zeta potential ? 20.548�mv, 87.379% entrapment efficiency, and a release rate of 91.521�?g/cm2/h. The results showed that liposomal insulin remained stable for 6�months in aqueous dispersion state at 4�C. Moreover, the release was sustained up to 24�h. The clinical study showed an improvement in the wound healing rate, 16 times, as the control group, with magnificent reduction in the erythema of the ulcer and no signs of hypoglycemia. Insulin-loaded liposomal chitosan gel showed a promising drug delivery system with high stability and sustained release. � 2019, American Association of Pharmaceutical Scientists.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19374&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1208/s12249-019-1363-6
dc.identifier.doiPubMed ID 30963353
dc.identifier.issn15309932
dc.identifier.otherhttps://doi.org/10.1208/s12249-019-1363-6
dc.identifier.otherPubMed ID 30963353
dc.identifier.urihttps://t.ly/vejlA
dc.language.isoEnglishen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofseriesAAPS PharmSciTech
dc.relation.ispartofseries20
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectinsulinen_US
dc.subjectishikawa diagramen_US
dc.subjectliposomesen_US
dc.subjectquality by designen_US
dc.subjectwound healingen_US
dc.subjectchitosanen_US
dc.subjectinsulinen_US
dc.subjectliposomeen_US
dc.subjectchitosanen_US
dc.subjectinsulinen_US
dc.subjectliposomeen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectcase studyen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug designen_US
dc.subjectdrug diffusionen_US
dc.subjectdrug formulationen_US
dc.subjectdrug hydrolysisen_US
dc.subjectdrug qualityen_US
dc.subjectdrug stabilityen_US
dc.subjectencapsulationen_US
dc.subjectexperimental designen_US
dc.subjectfactorial designen_US
dc.subjectgelen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectin vitro studyen_US
dc.subjectliposomal deliveryen_US
dc.subjectmucoadhesionen_US
dc.subjectparticle sizeen_US
dc.subjectpriority journalen_US
dc.subjectrandomized controlled trialen_US
dc.subjectsingle blind procedureen_US
dc.subjectsustained drug releaseen_US
dc.subjectviscometryen_US
dc.subjectwound healingen_US
dc.subjectzeta potentialen_US
dc.subjectdelayed release formulationen_US
dc.subjectdrug delivery systemen_US
dc.subjectdrug effecten_US
dc.subjecthydrogelen_US
dc.subjectpharmacologyen_US
dc.subjectwound healingen_US
dc.subjectChitosanen_US
dc.subjectDelayed-Action Preparationsen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectHydrogelsen_US
dc.subjectInsulinen_US
dc.subjectLiposomesen_US
dc.subjectParticle Sizeen_US
dc.subjectWound Healingen_US
dc.titleInsulin Mucoadhesive Liposomal Gel for Wound Healing: a Formulation with Sustained Release and Extended Stability Using Quality by Design Approachen_US
dc.typeArticleen_US
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