Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients
| dc.Affiliation | October university for modern sciences and Arts MSA | |
| dc.contributor.author | Farag, Azza Gaber Antar | |
| dc.contributor.author | Shoeib, Mohamed Abd AlMoneam | |
| dc.contributor.author | labeeb, Azza Zagloul | |
| dc.contributor.author | Sleem, Asmaa Shaaban | |
| dc.contributor.author | Khallaf, Hagar M | |
| dc.contributor.author | Khalifa, Amany Salah | |
| dc.contributor.author | Elshaib, Mustafa Elsayed | |
| dc.contributor.author | Elnaidany, Nada Farag | |
| dc.contributor.author | Hanout, Hayam Mohamed Aboelnasr | |
| dc.date.accessioned | 2023-01-03T11:24:31Z | |
| dc.date.available | 2023-01-03T11:24:31Z | |
| dc.date.issued | 2022-12 | |
| dc.description.abstract | Background: Vitiligo is an acquired depigmented skin disorder. It has a genetic and autoimmune background. Human beta defensin-1(HBD-1) plus its gene polymorphism were linked to some autoimmune disorders. Objective: To elucidate the possible role of HBD-1 in the pathogenesis of non-segmental vitiligo (NSV) through evaluation of HBD-1 serum levels and its single nucleotide polymorphism (SNP) in patients having NSV, in addition, to correlating the results with the extent of vitiligo in those patients. Methods: A current case-control study included 50 patients having NSV and 50 controls. The authors used Vitiligo Area Scoring Index (VASI) score to assess vitiligo severity and laboratory investigations to assess serum HBD-1 level using ELISA and defensin-beta1 (DEFB1) SNP using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=24247&tip=sid&clean=0 | |
| dc.identifier.doi | https://doi.org/10.1016/j.abd.2022.04.002 | |
| dc.identifier.other | https://doi.org/10.1016/j.abd.2022.04.002 | |
| dc.identifier.uri | http://repository.msa.edu.eg/xmlui/handle/123456789/5308 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier BV | en_US |
| dc.relation.ispartofseries | Anais Brasileiros de Dermatologia; | |
| dc.subject | Genes; | en_US |
| dc.subject | Polymorphism, | en_US |
| dc.subject | genetic; | en_US |
| dc.subject | Vitiligo | en_US |
| dc.title | Human beta-defensin 1 circulating level and gene polymorphism in non-segmental vitiligo Egyptian patients | en_US |
| dc.type | Article | en_US |