Cobalt oxide nanoparticles modified coated graphite potentiometric sensor for quantification of sulfacetamide sodium in its pharmaceutical dosage form and spiked rabbit aqueous humor samples with greenness assessment
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Date
2023-09
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Elsevier Inc
Series Info
Microchemical Journal;195 (2023) 109435
Scientific Journal Rankings
Abstract
This study presents the fabrication of an innovative coated graphite electrode modified with cobalt oxide
nanoparticles, for potentiometric determination of Sulfacetamide sodium. The functionalized nano-electrode was
compared to a classical one; to study the advantages of addition of nanoparticles which was found to improve the
performance characteristics of the electrode including improved sensitivity and selectivity, as well as, extended
operational lifespan. The functionalized nano-electrode was more sensitive than the classical one with linearity
range (1 × 10− 7
–1 × 10− 2 M) and a limit of detection down to 2.24 × 10− 8 M. This small modification increased
the electrode’s potential stability by preventing the formation of a water layer on the surface of the solid contact
electrode. The electrochemical performance of the proposed sensors was evaluated according to the IUPAC
recommendation data and was found to be within the acceptable ranges. These developed potentiometric
platforms were applied to quantitatively analyze Sulfacetamide sodium in its pure solutions, pharmaceutical
dosage form and spiked rabbit aqueous humor with satisfactory recovery percentages without pre-extraction
procedure nor interference of the co-formulated drug; Prednisolone acetate and excipients. The proposed
method was statistically compared with the reported method in literature and no statistically significant dif-
ference was found. The proposed method was evaluated for its environmental sustainability utilizing the Green
Analytical Procedure index (GAPI) as a greenness assessment tool.
Description
Keywords
Coated graphite electrode, Potentiometry, Sulfacetamide sodium, GAPI