Adipocyte of Obese Breast Cancer Patients Is Characterized by The Overexpression of Caveolin-1 Protein/Mediator the Main Constituent of the Plasma Membrane Vesicles Caveolae That Contain Proteins Contribute to Breast Cancer Progression
Date
2019
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Egyptian Society of Biological Sciences
Series Info
Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry;Article 1, Volume 12, Issue 1
Scientific Journal Rankings
Abstract
Breast cancer (BC) is the second leading mortality cause due to
poor survival rates compared to lung cancer all over the world.
Recently, lifestyle increased obesity among the population globally.
Since, the adipose tissues (AT) are the major contributor to the volume
of the breast and adipocytes cells, which constitute AT are one of the
major prominent cells play an effective role in cancer progression via
releasing different mediators and adipokines. Thus, AT may display a
crucial role in BC progression, especially in obese patients compared to
non-obese patients, which characterized by increased AT. Interestingly,
adipocytes are characterized by expressing caveolin-1 (Cav-1) protein.
Cav-1 constitutes the lipid raft of caveola which contains different
proteolytic enzymes inducing cancer metastasis. In this regard, the aim
of the present study was to explore the level of expression of Cav-1
protein in the tissue specimen of 5 non-obese vs. 15 obese patients using
immunohistochemistry (IHC) and immunoblotting techniques. Our
finding demonstrates that the level of Cav-1expression was statistically
significantly low in non-obese compared to obese BC patients (p <
0.05). Herein, our results revealed that the highest expression of Cav-1
in obese patients compared to non-obese (control) patients can be
considered as a biomarker for BC patients.
Description
MSA Google Scholar
Keywords
Breast cancer, adipose tissues
Citation
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