A new acylated flavonol from the aerial parts of Asteriscus maritimus (L.) Less (Asteraceae)

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Date

2016

Journal Title

Journal ISSN

Volume Title

Type

Article

Publisher

Taylor & Francis

Series Info

Natural product research;VOL : 30 Issue : 15

Abstract

Phytochemical investigation of the flowering aerial parts of Asteriscus maritimus (L.) Less (Asteraceae) led to the isolation of a new compound: patuletin 7-O-β-D-[(2″′S) 6″(3″′-hydroxy-2″′-methyl-propanoyl)] glucopyranoside, together with five known metabolites; β-sitosterol 2, chlorogenic acid 3, P-hydroxy -methylbenzoate 4, luteolin 5 and protocatechuic acid 6. The structures of the isolated compounds were determined by comprehensive analyses of its 1D and 2D NMR, HRMS and compared with previously known analogues. The ethanolic extract of the flowering aerial parts of A. maritimus was found to be safe (LD50 = 4.6 mg/kg) and possess significant antioxidant and anti-inflammatory activities and this was in accordance with its high phenolic content (107.36 ± 0.051 mg GAE/g extract).

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Keywords

Asteriscus Maritimus, Acylated Flavonol, Antioxidant, Anti-inflammatory

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