Silymarin and Curcumin has a Potential Hepato-Protective Effect against Chemically-Induced Liver Dysfunction

Abstract

The liver is important, essential, and vital organ in the body due to their function in body. Detection of hepatic dysfunction depends on the lab tests such as: Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) and alkaline phosphatase (ALP). Curcumin has been shown to protect liver in much models of liver injury by inhibiting oxidative damage. Twenty four adult male albino rats their average weight 150-200 g were divided into four group six rats in each group ; group1: served as a normal group, group 2:subjected to 0.5mg/kg ccl4 dissolved in olive oil s.c every other day for 3 weeks, group 3:subjected to ccl40.5mg/kg dissolved in olive oil s.c every other day in addition to Curcumin 200 mg/kg /d orally every day for 3 weeks, group 4: subjected to ccl40.5 mg/kg dissolved in olive oil s.c every other day in addition to silymarin 200mg/kg orally every day for 3 weeks. The administration of ccl4 cause hepatic dysfunction and increase in serum ALT, AST and ALP level. The administration of Curcumin and silymarin along with ccl4 showed a decrease in serum ALT, AST and ALP level. The hepatic-protective effect of Curcumin and silymarin are relating to reduced liver enzymes as ALT, AST and ALP in hepatic dysfunction that produced by CCl4 toxicity through an antioxidant effects, exerting anti-inflammatory and free radical diminish.