Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis

dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorAlseekh, S
dc.contributor.authorEzzat, Shahira M
dc.contributor.authorFarag, M.A
dc.contributor.authorFernie, A.R
dc.contributor.authorSerag, A.
dc.contributor.authorDe Souza, L.P
dc.contributor.authorSalem, M.A
dc.date.accessioned2020-02-16T09:26:35Z
dc.date.available2020-02-16T09:26:35Z
dc.date.issued2020-01
dc.descriptionMSA Google Scholar
dc.descriptionSCOPUSen_US
dc.description.abstractPlant‐derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the complex chemistry and presence of most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug research. Analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) are used to comprehensively annotate the constituents of plant natural products for screening, drug discovery as well as for quality control purposes such as those required for phytomedicine. In this review, the current advancements in plant sample preparation, sample measurements, and data analysis are presented alongside a few case studies of the successful applications of these processes in plant natural product drug discovery. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipHorizon 2020 Framework Programme Alexander von Humboldt-Stiftungen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100403902&tip=sid&clean=0
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dc.identifier.doihttps://doi.org/10.3390/metabo10010037
dc.identifier.issn22181989
dc.identifier.otherhttps://doi.org/10.3390/metabo10010037
dc.identifier.urihttps://cutt.ly/8tykAGz
dc.language.isoen_USen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMetabolites;Volume 10, Issue 1, January 2020, Article number 37
dc.subjectPlant natural productsen_US
dc.subjectNMRen_US
dc.subjectMetabolomicsen_US
dc.subjectMetabolite extractionen_US
dc.subjectMass spectrometryen_US
dc.subjectLiquid chromatographyen_US
dc.subjectGas chromatographyen_US
dc.subjectDrug discoveryen_US
dc.titleMetabolomics in the context of plant natural products research: From sample preparation to metabolite analysisen_US
dc.typeArticleen_US

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