Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEzzat, Shahira M
dc.contributor.authorShouman S.A.
dc.contributor.authorElkhoely A.
dc.contributor.authorAttia Y.M.
dc.contributor.authorElsesy M.S.
dc.contributor.authorEl Senousy A.S.
dc.contributor.authorChoucry M.A.
dc.contributor.authorEl Gayed S.H.
dc.contributor.authorEl Sayed A.A.
dc.contributor.authorSattar E.A.
dc.contributor.authorEl Tanbouly N.
dc.contributor.otherPharmacognosy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr El-Einy Street
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Science and Arts (MSA)
dc.contributor.other6th October
dc.contributor.other12566
dc.contributor.otherEgypt; Cancer Biology Department
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmacology and Toxicology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherHelwan University
dc.contributor.otherHelwan
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:49Z
dc.date.available2020-01-09T20:40:49Z
dc.date.issued2018
dc.descriptionScopus
dc.descriptionMSA Google Scholar
dc.description.abstractThe objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar Giza 9 (PFH-G9) contains the highest concentration of SDG (81.64 mg/g). The in vitro cytotoxic potentiality of PFH's of six flaxseed cultivars was screened against a panel of human cancer cell lines. PFH -G9 showed the most significant cytotoxic activity against ER-receptor positive breast cell lines MCF7 and T47D with IC50 13.8 and 15.8 ?g/ml, respectively. Moreover, PFH-G9 reduced the expression of the metastasis marker, 1-?, metalloproteinases and vascular endothelial growth factor (VEGF), one of the most potent stimulators of angiogenesis, while it increased the caspase-3 dependent apoptosis. Our study also showed that dietary intake of 10% of Giza 9 Flaxseeds (FS), fixed oil (FSO) or Flax meal (FSM) twice daily for 3 weeks in mice-bearing solid Ehrlich ascites carcinoma (EAC) resulted in reducing the tumor volume, the expression of estrogen, insulin growth factor, progesterone, VEGF and MMP-2, but enhanced expression of caspase-3. � 2018 The Author(s).en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=21100200805&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1038/s41598-017-18944-0
dc.identifier.doiPubMed ID 29323210
dc.identifier.issn20452322
dc.identifier.otherhttps://doi.org/10.1038/s41598-017-18944-0
dc.identifier.otherPubMed ID 29323210
dc.identifier.urihttps://t.ly/P5M8X
dc.language.isoEnglishen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofseriesScientific Reports
dc.relation.ispartofseries8
dc.subjectantineoplastic agenten_US
dc.subjectlignanen_US
dc.subjectplant extracten_US
dc.subjecttumor markeren_US
dc.subjectanimalen_US
dc.subjectapoptosisen_US
dc.subjectchemistryen_US
dc.subjectdrug effecten_US
dc.subjectexperimental mammary neoplasmen_US
dc.subjectfemaleen_US
dc.subjectflaxen_US
dc.subjectgeneticsen_US
dc.subjectHCT 116 cell lineen_US
dc.subjectHeLa cell lineen_US
dc.subjecthumanen_US
dc.subjectMCF-7 cell lineen_US
dc.subjectmetabolismen_US
dc.subjectmouseen_US
dc.subjectAnimalsen_US
dc.subjectAntineoplastic Agentsen_US
dc.subjectApoptosisen_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectFemaleen_US
dc.subjectFlaxen_US
dc.subjectHCT116 Cellsen_US
dc.subjectHeLa Cellsen_US
dc.subjectHumansen_US
dc.subjectLignansen_US
dc.subjectMammary Neoplasms, Experimentalen_US
dc.subjectMCF-7 Cellsen_US
dc.subjectMiceen_US
dc.subjectPlant Extractsen_US
dc.titleAnticancer potentiality of lignan rich fraction of six Flaxseed cultivarsen_US
dc.typeArticleen_US
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