Design, synthesis, molecular docking and biological evaluation of some new thiophene derivatives as anti-cancer agents

Abstract

Structure-based design, synthesis and biological evaluation of newly synthesized small molecules anti-cancer agents were described. On continuation of applying scaffold hopping theory, a series of substituted 2-amino, 3- cyanothiophene based on the structural features of Sorafenib was designed, synthesized and evaluated as cytotoxic agents against MCF7 and HCT 116 cell lines. Substituting the amino group of 2-aminothiophene with different pharmacophoric groups led to discovery of two potent lead compounds IIIb and IIIc with excellent cytotoxic activity against MCF7 and HCT 116 cell lines.