Design, synthesis, molecular docking and biological evaluation of some new thiophene derivatives as anti-cancer agents
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Date
2019
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
ejpmr
Series Info
EUROPEAN JOURNAL OF PHARMACEUTIAND MEDICAL RESEARCHCAL;2019,6(12), 160-167
Doi
Scientific Journal Rankings
Abstract
Structure-based design, synthesis and biological evaluation of newly synthesized small molecules anti-cancer
agents were described. On continuation of applying scaffold hopping theory, a series of substituted 2-amino, 3-
cyanothiophene based on the structural features of Sorafenib was designed, synthesized and evaluated as cytotoxic
agents against MCF7 and HCT 116 cell lines. Substituting the amino group of 2-aminothiophene with different
pharmacophoric groups led to discovery of two potent lead compounds IIIb and IIIc with excellent cytotoxic
activity against MCF7 and HCT 116 cell lines.
Description
Keywords
Thiophene Derivatives and Structure-based Drug design, VEGFR-2, Angiogenesis, Anti-Cancer Agents