Development and validation of smart spectrophotometric-chemometric methods for the simultaneous determination of chlorpheniramine maleate and etilefrine hydrochloride in bulk powder and in dosage form combinations

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorMohsen A.M.
dc.contributor.authorBadawey A.M.
dc.contributor.authorShehata M.A.
dc.contributor.authorElkhateeb S.Z.
dc.contributor.otherAnalytical Chemistry Department
dc.contributor.otherMSA University
dc.contributor.other6th October City
dc.contributor.otherGiza
dc.contributor.otherEgypt; Analytical Chemistry Department
dc.contributor.otherCairo University
dc.contributor.otherKasrElinist
dc.contributor.other11562
dc.contributor.otherCairo
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:42:12Z
dc.date.available2020-01-09T20:42:12Z
dc.date.issued2014
dc.descriptionScopus
dc.description.abstractThis paper describes threesensitive, accurate and precise chemometricspectrophotometricmethods for the simultaneous determination of chlorpheniramine maleate (CPM) and etilefrine hydrochloride (ETF)in bulk powder and capsules without prior separation. Multivariate calibration chemometric methods are proposed for simultaneous determination of CPMandETF. The chemometric methods applied are classical least squares (CLS),principal component regression (PCR) and partial least squares (PLS). These approaches aresuccessfully applied to quantify both drugs using the information included in the absorption spectra of appropriate solutions.In these multivariatemethods, calibration sets of standard samples composed of different mixtures of CPMand ETFhave been designed. The methods were validated according to the International Conference on Harmonization (ICH) guidelines. The specificity of the proposed methods was tested using laboratory-prepared mixtures. The developed methods were successfully applied for the determination of CPM and ETF in bulk powder and dosage form combination.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=19700174810&tip=sid&clean=0
dc.identifier.doihttps://doi.org/
dc.identifier.issn9751491
dc.identifier.otherhttps://doi.org/
dc.identifier.urihttps://t.ly/j67r8
dc.language.isoEnglishen_US
dc.publisherIJPPSen_US
dc.relation.ispartofseriesInternational Journal of Pharmacy and Pharmaceutical Sciences
dc.relation.ispartofseries6
dc.subjectAntihistaminic drugsen_US
dc.subjectChemometricen_US
dc.subjectChlorpheniramine maleateen_US
dc.subjectCLSen_US
dc.subjectEtilefrine hydrochlorideen_US
dc.subjectPCRen_US
dc.subjectPLSen_US
dc.subjectchlorpheniramine maleateen_US
dc.subjectetilefrineen_US
dc.subjectexcipienten_US
dc.subjectanalytic methoden_US
dc.subjectarticleen_US
dc.subjectcalibrationen_US
dc.subjectchemometric analysisen_US
dc.subjectdrug determinationen_US
dc.subjectdrug dosage formen_US
dc.subjectdrug stabilityen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjectlinearityen_US
dc.subjectmeasurement accuracyen_US
dc.subjectmeasurement precisionen_US
dc.subjectmeasurement repeatabilityen_US
dc.subjectprocess optimizationen_US
dc.subjectrangeen_US
dc.subjectreproducibilityen_US
dc.subjectspectral sensitivityen_US
dc.subjectspectrophotometryen_US
dc.subjectvalidation processen_US
dc.titleDevelopment and validation of smart spectrophotometric-chemometric methods for the simultaneous determination of chlorpheniramine maleate and etilefrine hydrochloride in bulk powder and in dosage form combinationsen_US
dc.typeArticleen_US
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