Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorZaafan M.A.
dc.contributor.authorZaki H.F.
dc.contributor.authorEl-Brairy A.I.
dc.contributor.authorKenawy S.A.
dc.contributor.otherPharmacology & Toxicology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts
dc.contributor.otherCairo
dc.contributor.otherEgypt; Pharmacology & Toxicology Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:30Z
dc.date.available2020-01-09T20:41:30Z
dc.date.issued2016
dc.descriptionScopus
dc.description.abstractObjective: The current study aimed to investigate the modulatory effects of pyrrolidinedithiocarbamate (PDTC; 100. mg/kg) on bleomycin-induced pulmonary fibrosis (5�mg/kg; intratracheal) in rats. Materials and Methods: Rats were randomly assigned to three groups: normal control, bleomycin control, and PDTC-treated groups. Lung injury was evaluated through histological examination, immunohistochemical detection of inducible nitric oxide synthase (iNOS) in lung tissue and evaluating the total and differential leucocytes count in bronchoalveolar lavage fluid. Lung tissue was used for biochemical assessment of lung content of hydroxyproline, transforming growth factor beta-1 (TGF-?1), tumor necrosis factor-alpha (TNF-?) as well as analysis of lipid peroxides, reduced glutathione (GSH), and total nitrite contents. Results: PDTC attenuated bleomycin-induced pulmonary fibrosis as evidenced by histological observations, decreased iNOS expression and prevention of bleomycin-induced altered total and differential leukocytes count. Additionally, PDTC caused a significant decrease in lung contents of hydroxyproline, TGF-?1, TNF-?, lipid peroxides, and total nitrite coupled with increase in lung GSH content as compared to bleomycin control group. Conclusion: PDTC attenuated bleomycin-induced pulmonary fibrosis in rats via its anti-inflammatory, antioxidant, and antifibrotic activities. � 2016 Taylor & Francis.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=18480&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1080/01902148.2016.1244578
dc.identifier.doiPubMed ID 27797599
dc.identifier.issn1902148
dc.identifier.otherhttps://doi.org/10.1080/01902148.2016.1244578
dc.identifier.otherPubMed ID 27797599
dc.identifier.urihttps://t.ly/BXOqX
dc.language.isoEnglishen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofseriesExperimental Lung Research
dc.relation.ispartofseries42
dc.subjectbleomycinen_US
dc.subjectnitric oxideen_US
dc.subjectpulmonary fibrosisen_US
dc.subjectpyrrolidinedithiocarbamateen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjectbleomycinen_US
dc.subjectcollagenen_US
dc.subjectglutathioneen_US
dc.subjecthydroxyprolineen_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjectlipid peroxideen_US
dc.subjectmalonaldehydeen_US
dc.subjectnitriteen_US
dc.subjectpyrrolidine dithiocarbamateen_US
dc.subjecttransforming growth factor beta1en_US
dc.subjecttumor necrosis factoren_US
dc.subjectantiinflammatory agenten_US
dc.subjectantioxidanten_US
dc.subjectbleomycinen_US
dc.subjectpyrrolidine derivativeen_US
dc.subjectpyrrolidine dithiocarbamic aciden_US
dc.subjectthiocarbamic acid derivativeen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantifibrotic activityen_US
dc.subjectantiinflammatory activityen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectbiochemical analysisen_US
dc.subjectbleomycin-induced pulmonary fibrosisen_US
dc.subjectbronchoalveolar lavage fluiden_US
dc.subjectclinical evaluationen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug activityen_US
dc.subjectdrug efficacyen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinflammationen_US
dc.subjectleukocyte differential counten_US
dc.subjectlipid peroxidationen_US
dc.subjectlung injuryen_US
dc.subjectlung lavageen_US
dc.subjectlung parenchymaen_US
dc.subjectlung structureen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectpriority journalen_US
dc.subjectprotein expressionen_US
dc.subjectraten_US
dc.subjectanimalen_US
dc.subjectchemically induceden_US
dc.subjectdrug effectsen_US
dc.subjectinflammationen_US
dc.subjectpathologyen_US
dc.subjectPulmonary Fibrosisen_US
dc.subjectAnimalsen_US
dc.subjectAnti-Inflammatory Agentsen_US
dc.subjectAntioxidantsen_US
dc.subjectBleomycinen_US
dc.subjectInflammationen_US
dc.subjectOxidative Stressen_US
dc.subjectPulmonary Fibrosisen_US
dc.subjectPyrrolidinesen_US
dc.subjectRatsen_US
dc.subjectThiocarbamatesen_US
dc.titlePyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parametersen_US
dc.typeArticleen_US
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