Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) 3 Predicts Poor Outcome in Pediatric T-acute Lymphoblastic Leukemia

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEL-Khazragy, Nashwa
dc.contributor.authorAbdel Aziz, Mahfouz A
dc.contributor.authorHesham, Manar
dc.contributor.authorMatbouly, Safa
dc.contributor.authorAbdallah Mostafa, Sally
dc.contributor.authorBakkar, Ashraf
dc.contributor.authorAbouelnile, Mariam
dc.contributor.authorNoufal, Yassmin
dc.contributor.authorMahran, Nievin Ahmed
dc.contributor.authorAbdlkhalek, Marwa Ali
dc.contributor.authorAbdelmaksoud, Mariam Fathy
dc.date.accessioned2021-10-29T09:17:46Z
dc.date.available2021-10-29T09:17:46Z
dc.date.issued10/26/2021
dc.descriptionSJR 2024 0.694 Q2 H-Index 112
dc.description.abstractT-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for around 10-15% of all lymphoblastic leukemia in children. Previous studies have proven that dysregulation of Leukemia-induced non-coding activator RNA-1 (LUNAR1) expression promotes T-ALL cell growth by enhancing the NOTCH1/IGF-1R signaling pathway. We aimed to investigate the prognostic value of LUNAR1 in pediatric T-ALL, in addition, to find out its association with NOTCH1 and IGF-1R. The LUNAR1, NOTCH1, and IGF-IR gene expression were measured in peripheral blood (PB) samples of l85 children with T-ALL and forty non-leukemic samples as a control group. Cox regression analysis revealed that overexpression of LUNAR1, NOTCH1, and IGF-IR was significantly correlated with poor prognosis, short overall survival, and progression-free survival. We concluded that LUNAR1 could serve as an independent prognostic biomarker for T-ALL in children.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=20805&tip=sid&clean=0
dc.identifier.citationEl-Khazragy, N., Aziz, M. a. A., Hesham, M., Matbouly, S., Mostafa, S. A., Bakkar, A., Abouelnile, M., Noufal, Y., Mahran, N. A., Elkhalek, M. a. A., & Abdelmaksoud, M. F. (2021). Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) predicts poor outcome in pediatric T-acute lymphoblastic leukemia. Immunobiology, 226(6), 152149. https://doi.org/10.1016/j.imbio.2021.152149
dc.identifier.doihttps://doi.org/10.1016/j.imbio.2021.152149
dc.identifier.otherhttps://doi.org/10.1016/j.imbio.2021.152149
dc.identifier.urihttps://bit.ly/311nb6b
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesImmunobiology;152149
dc.subjectLong non-coding activator RNA (LUNAR1)en_US
dc.subjectPediatric T-acute Lymphoblastic Leukemiaen_US
dc.subjectPrognostic biomarker.en_US
dc.subjectpredictor biomarkeren_US
dc.titleUpregulation of leukemia-induced non-coding activator RNA (LUNAR1) 3 Predicts Poor Outcome in Pediatric T-acute Lymphoblastic Leukemiaen_US
dc.typeArticleen_US

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