Eco-friendly-assessed TLC-densitometry and absorptivity coefficient based spectrophotometric methods for resolution and simultaneous analysis of two gastrointestinal acting drugs with superimposed spectra
Date
2020-11
Authors
Journal Title
Journal ISSN
Volume Title
Type
Article
Publisher
Elsevier Inc.
Series Info
Microchemical Journal;Volume 158, November 2020, Article number 105161
Scientific Journal Rankings
Abstract
Three eco-friendly methods were applied and validated for simultaneous determination of two commonly prescribed drugs for gastro-intestinal treatment Ranitidine hydrochloride and Metronidazole in bulk powder and in their pharmaceutical preparations in the ratio of 3:5. The first two methods were based on smart spectra manipulating approaches to resolve the zero-order spectrum of each drug as single pure component and measuring their concentrations using the absorbance value at the corresponding λ max, 325 nm and 311 nm for Ranitidine and Metronidazole, respectively. Both methods named response correlation method and a- centering method depend on the presence of an isosbestic point between the superimposed spectra of both drugs. While the third method was a TLC-densitometric one which was performed on silica plates F254 using a mobile phase composed of methanol and ethyl acetate in a ratio (24:6 v/v). The results of the presented methods came out to be acceptable with respect to accuracy and precision and the selectivity was evaluated through analysis of synthetic mixtures of the both drugs in different ratios. All the results were validated according to the ICH guidelines. The green character of the developed methods was assessed using a new tool called Green Analytical Procedure Index (GAPI)
Description
Scopus
Keywords
Metronidazole, Ranitidine, TLC-densitometry, Isosbestic point, Absorbance difference, Factorized spectrum, Green
Citation
Remington, J. Remington Pharmaceutical Sciences (1985) . Cited 633 times. 17th ed. Mack Publishing Co USA 2 Sun, X., Tian, Y., Zhang, Z., Chen, Y. A single LC-tandem mass spectrometry method for the simultaneous determination of four H2 antagonists in human plasma (2009) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 877 (31), pp. 3953-3959. Cited 25 times. doi: 10.1016/j.jchromb.2009.10.003 View at Publisher 3 Löfmark, S., Edlund, C., Nord, C.E. Metronidazole is still the drug of choice for treatment of anaerobic infections (Open Access) (2010) Clinical Infectious Diseases, 50 (SUPP.1), pp. S16-S23. Cited 280 times. doi: 10.1086/647939 View at Publisher 4 Farup, P.G., Tholfsen, J., Wetternus, S., Torp, R., Høie, O., Lange, O.J. Comparison of three triple regimens with omeprazole or ranitidine bismuth citrate for Helicobacter pylori eradication (2002) Scandinavian Journal of Gastroenterology, 37 (12), pp. 1374-1379. Cited 19 times. doi: 10.1080/003655202762671233 View at Publisher 5 King'Ori, L.D., Walker, R.B. HPLC method for simultaneous analysis of ranitidine and metronidazole in dosage forms (Open Access) (2014) Asian Journal of Chemistry, 26 (2), pp. 426-430. Cited 4 times. http://www.asianjournalofchemistry.co.in/Journal/ViewArticle.aspx?ArticleID=26_3_28 doi: 10.14233/ajchem.2014.15432 View at Publisher 6 Do Nascimento, T.G., De Jesus Oliveira, E., Macêdo, R.O. Simultaneous determination of ranitidine and metronidazole in human plasma using high performance liquid chromatography with diode array detection (2005) Journal of Pharmaceutical and Biomedical Analysis, 37 (4), pp. 777-783. Cited 63 times. www.elsevier.com/locate/jpba doi: 10.1016/j.jpba.2004.11.042 View at Publisher 7 Salimi, A., Izadi, M., Hallaj, R., Rashidi, M. Simultaneous determination of ranitidine and metronidazole at glassy carbon electrode modified with single wall carbon nanotubes (2007) Electroanalysis, 19 (16), pp. 1668-1676. Cited 60 times. doi: 10.1002/elan.200703911 View at Publisher 8 Li, X., Xu, G. Simultaneous determination of ranitidine and metronidazole in pharmaceutical formulations at poly(chromotrope 2B) modified activated glassy carbon electrodes (Open Access) (2014) Journal of Food and Drug Analysis, 22 (3), pp. 345-349. Cited 22 times. http://www.elsevier.com/journals/journal-of-food-and-drug-analysis/1021-9498# doi: 10.1016/j.jfda.2013.09.050 View at Publisher 9 Lotfy, H.M., Mohamed, D., Elshahed, M.S. Different mathematical processing of absorption, ratio and derivative spectra for quantification of mixtures containing minor component: An application to the analysis of the recently co-formulated antidiabetic drugs; canagliflozin and metformin (2018) Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 189, pp. 100-109. Cited 7 times. doi: 10.1016/j.saa.2017.08.015 View at Publisher 10 Lotfy, H.M., Omran, Y.R. Novel absorptivity centering method utilizing normalized and factorized spectra for analysis of mixtures with overlapping spectra in different matrices using built-in spectrophotometer software (2018) Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 200, pp. 167-178. Cited 6 times. doi: 10.1016/j.saa.2018.04.004 View at Publisher 11 Mohamed, E.H., Lotfy, H.M., Hegazy, M.A., Mowaka, S. Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra (Open Access) (2017) Chemistry Central Journal, 11 (1), art. no. 43. Cited 9 times. http://www.journal.chemistrycentral.com/home/ doi: 10.1186/s13065-017-0270-8 View at Publisher 12 Obaydo, R.H., Alhaj Sakur, A. Spectrophotometric strategies for the analysis of binary combinations with minor component based on isoabsorptive point's leveling effect: An application on ciprofloxacin and fluocinolone acetonide in their recently delivered co-formulation (2019) Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 219, pp. 186-194. Cited 4 times. doi: 10.1016/j.saa.2019.04.036 View at Publisher 13 Christine, M.E.-M., Ekram, H.M. Successive stability indicating spectrophotometric technique for simultaneous determination of quetiapine fumarate and its three major related compounds (2018) Curr. Anal. Chem., 14, pp. 1-9. 14 Ekram, H.M., Ahmed, H., Aya, R., Sara, A., Ola, A. A smart green spectrophotometric method for simultaneous determination of severely overlapped binary mixtures using normalized spectrum and isosbestic point as resolving tools (2018) Curr. Pharm. Anal., 14, pp. 1-8. 15 Fouad, M.M., El-Maraghy, C.M. Rapid validated thin-layer chromatography-densitometry for the simultaneous determination of three co-formulated drugs used for common cold treatment (2019) Journal of Planar Chromatography - Modern TLC, 32 (2), pp. 127-131. https://akademiai.com/doi/pdf/10.1556/1006.2019.32.2.8 doi: 10.1556/1006.2019.32.2.8 View at Publisher 16 Salem, H., Amer, S.M., Maraghy, C.M.E., Nebsen, M. Validated HPLC and thin layer-densitometric methods for determination of quetiapine fumarate in presence of its related compounds (2015) J. Chromatogr. Sep. Tech., 6, pp. 1-7. Cited 2 times. 17 Naveed, S., Qamar, F. Simple UV Spectrophotometric Assay of Metronidazole (2014) OALib., 1, pp. 1-4. Cited 5 times. 18 Mishra, A.N., Rana, A.C. UV spectrophotometric determination of ranitidine hydrochloride in pure and pharmaceutical formulation (2009) Int. J. Chem. Sci., 7, pp. 2208-2210. Cited 6 times. 19 Płotka-Wasylka, J. A new tool for the evaluation of the analytical procedure: Green Analytical Procedure Index (2018) Talanta, 181, pp. 204-209. Cited 101 times. https://www.journals.elsevier.com/talanta doi: 10.1016/j.talanta.2018.01.013 View at Publisher 20 Tobiszewski, M., Mechlinska, A., Namie, J. Green analytical chemistry—theory and practice (2010) Chemical Society Reviews, 39 (8), pp. 2869-2878. Cited 164 times. doi: 10.1039/b926439f View at Publisher 21 Alfonsi, K., Colberg, J., Dunn, P.J., Fevig, T., Jennings, S., Johnson, T.A., Kleine, H.P., (...), Stefaniak, M. Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation (2008) Green Chemistry, 10 (1), pp. 31-36. Cited 632 times. doi: 10.1039/b711717e View at Publisher 22 Prat, D., Wells, A., Hayler, J., Sneddon, H., McElroy, C.R., Abou-Shehada, S., Dunn, P.J. CHEM21 selection guide of classical- and less classical-solvents (Open Access) (2016) Green Chemistry, 18 (1), pp. 288-296. Cited 490 times. http://pubs.rsc.org/en/journals/journal/gc doi: 10.1039/c5gc01008j View at Publisher 23 Tobiszewski, M. Metrics for green analytical chemistry (Open Access) (2016) Analytical Methods, 8 (15), pp. 2993-2999. Cited 63 times. http://www.rsc.org/Publishing/Journals/AY/About.asp doi: 10.1039/c6ay00478d