Profile of bioactive compounds of Capparis spinosa var.Aegyptiaca growing in Egypt

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorBakr R.O.
dc.contributor.authorEl Bishbishy M.H.
dc.contributor.otherPharmacognosy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:40Z
dc.date.available2020-01-09T20:41:40Z
dc.date.issued2016
dc.descriptionScopus
dc.description.abstractThe present study was designed to investigate polyphenolic and sulphur contents of the aerial parts of Capparis spinosa var.aegyptia (Lam.) Boiss., Capparaceae, wildly growing in Egypt.The chemical compositions of the water distilled essential oil were investigated by GC/MS analysis where the major constituent of the oil was methyl isothiocyanate (24.66%).Hydroethanolic extract was evaluated by LC-HRESI-MS-MS in both positive and negative modes.Forty-two compounds were identified including quercetin, kaempferol and isorhamnetin derivatives in addition to myricetin, eriodictyol, cirsimaritin and gallocatechin derivatives.Quercetin tetrahexoside dirhamnoside as well as kaempferol dihexoside dirhamnoside have not been identified before in genus Capparis.Phenolic acids, such as quinic acid, p-coumaroyl quinic acid and chlorogenic acid were also identified.Evaluation of cytotoxic activity of hydroethanolic extract against three human cancer cell lines (MCF-7; breast adenocarcinoma cells, Hep-G2; hepatocellular carcinoma cells and HCT-116; colon carcinoma) using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay showed significant effect with IC50 values 24.5, 24.4 and 11 g/ml, compared to Doxorubicin as a standard cytotoxic drug.C.spinosa revealed itself as a promising candidate for nutraceutical researches. 2016 Sociedade Brasileira de Farmacognosia.en_US
dc.identifier.doihttps://doi.org/10.1016/j.bjp.2016.04.001
dc.identifier.doiPubMed ID :
dc.identifier.issn0102695X
dc.identifier.otherhttps://doi.org/10.1016/j.bjp.2016.04.001
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/dOgp6
dc.language.isoEnglishen_US
dc.publisherSociedade Brasileira de Farmacognosiaen_US
dc.relation.ispartofseriesBrazilian Journal of Pharmacognosy
dc.relation.ispartofseries26
dc.subjectCapparis spinosaen_US
dc.subjectCytotoxicityen_US
dc.subjectFlavonoidsen_US
dc.subjectIsothiocyanateen_US
dc.subjectLC-HRESI-MS-MSen_US
dc.subject4 coumaroyl quinic aciden_US
dc.subjectabsintholen_US
dc.subjectcamphoren_US
dc.subjectCapparis spinosa extracten_US
dc.subjectcaryophylleneen_US
dc.subjectchlorogenic aciden_US
dc.subjectcirsimaritinen_US
dc.subjectcopaeneen_US
dc.subjectdoxorubicinen_US
dc.subjecteriodictyolen_US
dc.subjectessential oilen_US
dc.subjectgallocatechinen_US
dc.subjectgamma muuroleneen_US
dc.subjectglucosinolateen_US
dc.subjecthumuleneen_US
dc.subjectisopropyl isothiocyanateen_US
dc.subjectisorhamnetinen_US
dc.subjectkaempferolen_US
dc.subjectkaempferol dihexoside dirhamnosideen_US
dc.subjectmethyl isothiocyanateen_US
dc.subjectmyricetinen_US
dc.subjectpara cymeneen_US
dc.subjectplant extracten_US
dc.subjectplant medicinal producten_US
dc.subjectquercetinen_US
dc.subjectquercetin tetrahexoside dirhamnosideen_US
dc.subjectquinic aciden_US
dc.subjectspathulenolen_US
dc.subjectsulforaphaneen_US
dc.subjectunclassified drugen_US
dc.subjectunindexed drugen_US
dc.subjectantineoplastic activityen_US
dc.subjectArticleen_US
dc.subjectCapparis spinosaen_US
dc.subjectchemical compositionen_US
dc.subjectcollisionally activated dissociationen_US
dc.subjectcontrolled studyen_US
dc.subjectcytotoxicityen_US
dc.subjectelectrospray mass spectrometryen_US
dc.subjectherbal medicineen_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectmass fragmentographyen_US
dc.subjectMTT assayen_US
dc.subjectplant structuresen_US
dc.titleProfile of bioactive compounds of Capparis spinosa var.Aegyptiaca growing in Egypten_US
dc.typeArticleen_US
dcterms.isReferencedByAbad-Garca, B., Garmn-Lobato, S., Berrueta, L.A., Gallo, B., Vicente, F., New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry (2008) Rapid Commun.Mass Spectrom, 22, pp. 1834-1842; Adams, R.P., (2004) Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy, , Allured Publishing Corporation Carol Stream, IL, USA; Afsharypuor, S., Jazy, A.R., Stachydrine and volatile isothiocyanates from the unripe fruit of Capparis spinosa L (1999) DARU, 7, pp. 11-13; Ahmed, Z.F., Rizk, A.M., Hammouda, F.M., Seif El Nasr, M.M., Glucosinolates of Egyptian Capparis species (1972) Phytochemistry, 11, pp. 251-256; Ali-Shtayeh, M.S., Abu Ghdeib, S.L., Antifungal activity of plant extracts against dermatophytes (1999) Mycoses, 42, pp. 665-672; Al-Said, M.S., Abdelsattar, E.A., Khalifa, S.I., El-Feraly, F.S., Isolation and identification of an anti-inflammatory principle from Capparis spinosa (1988) Pharmazie, 43, pp. 640-641; Baytop, P., (1984) Therapy with Medicinal Plants (Past and Present), , Istanbul University Publications, Istanbul; Behnaz, M., Davood, E.A., Atena, A., Diurnal change in rutin content in Capparis spinosa growing wild in Tafresh/Iran (2013) Eur.J.Exp.Biol, 3, pp. 30-34; Boik, J., (2001) Natural Compounds in Cancer Therapy, , Oregon Medical Press, MN, USA; Brevard, H., Brambille, M., Chaintreau, A., Marion, J.P., Occurrence of elemental sulphur in capers (Capparis spinosa L.) and first investigation of the flavour profile (1992) Flavour Fragr.J, 7, pp. 313-321; Cuyckens, F., Claeys, M., Mass spectrometry in the structural analysis of flavonoids (2004) J.Mass Spectrom, 39, pp. 1-15; Dueas, M., Mingo-Chornet, H., Prez-Alonso, J.J., Paola-Naranjo, R.D., Gonzlez-Params, A.M., Santos-Buelga, C., Preparation of quercetin glucuronides and characterization by HPLC-DAD-ESI/MS (2008) Eur.Food Res.Technol, 227, pp. 1069-1076; Eddouks, M., Lemhadri, A., Michel, J.B., Hypolipidemic activity of aqueous extract of Capparis spinosa L.In normal and diabetic rats (2005) J.Ethnopharmacol, 98, pp. 345-350; Fal, P.L., Ferreira, C., Rodrigues, A.M., Cleto, P., Madeira, P.J.A., Florncio, M.H., Frazo, F.N., Serralheiro, M.L.M., Antioxidant and anti-acetylcholinesterase activity of commercially available medicinal infusions after in vitro gastrointestinal digestion (2013) J.Med.Plants Res, 7, pp. 1370-1378; Felipe, D.F., Brambilla, L.Z.S., Porto, C., Pilau, E.J., Cortez, D.A.G., Phytochemical analysis of Pfaffia glomerata inflorescences by LC-ESI-MS/MS (2014) Molecules, 19, pp. 15720-15734; Ferreres, F., Gil-Izquierdo, A., Valento, P., Rade, P.B., Structural characterization of phenolics and betacyanins in Gomphrena globosa by high performance liquid chromatography diode array detection/electrospray ionization multi-stage mass spectrometry (2011) Rapid Commun.Mass Spectrom, 25, pp. 3441-3446; Fotakis, G., Timbrell, J.A., In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride (2006) Toxicol.Lett, 160, pp. 171-177; Fouche, G., Cragg, G.M., Pillay, P., Kolesnikova, N., Maharaj, V.J., Senabe, J., In vitro anticancer screening of South African plants (2008) J.Ethnopharmacol, 119, pp. 455-461; Gadgoli, C., Mishra, S.H., Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa (1999) J.Ethnopharmacol, 66, pp. 187-192; Gull, T., Anwar, F., Sultanaa, B., Alcayde, M.A.C., Nouman, W., Capparis species: A potential source of bioactives and high-value components: A review (2015) Ind.Crops Prod, 67, pp. 81-96; Hamed, A.R., Abdel-Shafeek, K.A., Abdel-Azim, N.S., Ismail, S.I., Hammouda, F.M., Chemical investigation of some Capparis species growing in Egypt and their antioxidant activity (2007) Ecam, 4, pp. 25-28; Hassaan, Y., Handoussa, H., El-Khatib, A.H., Linscheid, M.W., El Sayed, N., Ayoub, N., Evaluation of plant phenolic metabolites as a source of Alzheimer's drug leads (2014) Biomed.Res.Int, , http://dx.doi.org/10.1155/2014/843263; Hossain, M., Dilip, K., Brunton, N., Martin-Diana, A., Barry-Ryan, C., Characterization of phenolic composition in Lamiaceae spices by LC-ESI-MS/MS (2010) J.Agric.Food Chem, 58, pp. 10576-10581; Ibrahim, R.M., El-Halawany, A.M., Saleh, D.O., El Naggar, E.B., El-Shabrawy, A.O., El-Hawary, S.S., HPLC-DAD-MS/MS profiling of phenolics from Securigera securidaca flowers and its anti-hyperglycemic and anti-hyperlipidemic activities (2015) Rev.Bras.Farmacogn, 25, pp. 134-141; Inocencio, C., Rivera, D., Alcaraz, F., Tom�s-Barber�n, F.A., Flavonoid content of commercial capers (Capparis spinosa, C.Sicula and C.Orientalis) produced in mediterranean countries (2000) Eur.Food Res.Technol, 212, pp. 70-74; Kiddle, G., Bennett, R.N., Botting, N.P., Davidson, N.E., Robertson, A.B., Wallsgrove, R.M., High-performance liquid chromatographic separation of natural and synthetic desulphoglucosinolates and their chemical validation by UV NMR and chemical ionisation-MS methods (2001) Phytochem.Anal, 12, pp. 226-242; Kim, H., Park, S.H., Metabolic profiling and discrimination of two cacti cultivated in Korea using HPLC-ESI-MS and multivariate statistical analysis (2009) J.Korean Soc.Appl.Biol.Chem, 52, pp. 346-352; Kulisic-Bilusic, T., Schmller, I., Schnbele, K., Siracusa, L., Ruberto, G., The anticarcinogenic potential of essential oil and aqueous infusion from caper (Capparis spinosa L.) (2012) Food Chem, 132, pp. 261-267; Li, F., Zhang, L.D., Li, B.C., Yang, J., Yu, H., Wan, J.B., Wang, Y.T., Li, P., Screening of free radical scavengers from Erigeron breviscapus using on-line HPLC-ABTS/DPPH based assay and mass spectrometer detection (2012) Free Radic.Res, 46, pp. 286-294; Lin, L.Z., Harnly, J.M., Identification of the phenolic components of chrysanthemum flower (Chrysanthemum morifolium Ramat) (2010) Food Chem, 120, pp. 319-326; Martucci, M.E.P., De Vos, R.C.H., Carollo, C.A., Gobbo-Neto, L., Metabolomics as chemotaxonomical tool: Application in the genus Vernonia Schreb (2014) PLOS ONE, 9; Navarro-Gonzlez, I., Gonzlez-Barrio, R., Garca-Valverde, V., Bautista-Ortn, A.B., Periago, M.J., Nutritional composition and antioxidant capacity in edible flowers: Characterisation of phenolic compounds by HPLC-DAD-ESI/MSn (2015) Int.J.Mol.Sci, 16, pp. 805-822; Qu, C., Fu, F., Lu, K., Zhang, K., Wang, R., Xu, X., Wang, M., Li, J., Differential accumulation of phenolic compounds and expression of related genes in black- and yellow-seeded Brassica napus (2013) J.Exp.Bot, 64, pp. 2885-2898; Raal, A., Boikova, T., Pssa, T., Content and dynamics of polyphenols in Betula spp.Leaves naturally growing in Estonia (2015) Rec.Nat.Prod, 9, pp. 41-48; Rodrigo, M., Lazaro, M.J., Alvarruiz, A., Giner, V., Composition of capers (Capparis spinosa): Influence of cultivar, size and harvest date (1992) J.Food Sci, 57, pp. 1152-1154; Romeo, V., Ziino, M., Giuffrida, D., Condurso, C., Verzera, A., Flavour profile of capers (Capparis spinosa L.) from the Eolian Archipelago by HS-SPME/GC-MS (2007) Food Chem, 101, pp. 1272-1278; Roriz, C.L., Barros, L., Carvalho, A.M., Santos-Buelga, C., Ferreira, I.C.F.R., Pterospartum tridentatum,Gomphrena globosa and Cymbopogon citratus: A phytochemical study focused on antioxidant compounds (2014) Food Res.Int, 62, pp. 684-693; Saad, B., Said, O., (2011) Greco-Arab and Islamic Herbal Medicine: Traditional System, Ethics, Safety, Efficacy, and Regulatory Issues, pp. 208-211. , John Wiley & Sons, Inc., Hoboken, NJ; Snchez-Rabaneda, F., Juregui, O., Lamuela-Ravents, R.M., Viladomat, F., Bastida, J., Codina, C., Qualitative analysis of phenolic compounds in apple pomace using liquid chromatography coupled to mass spectrometry in tandem mode (2004) Rapid Commun.Mass Spectrom, 18, pp. 553-563; Sharaf, M., El-Ansari, M.A., Saleh, N.A., Flavonoids of four Cleom and three Capparis species (1997) Biochem.Syst.Ecol, 25, pp. 161-166; Sharaf, M., El-Ansari, M.A., Saleh, N.A., Quercetin triglycoside from Capparis spinosa (2000) Fitoterapia, 71, pp. 46-49; Siracusa, L., Kulisic-Bilusic, T., Politeo, O., Krause, I., Dejanovic, B., Ruberto, G., Phenolic composition and antioxidant activity of aqueous infusions from Capparis spinosa L.And Crithmum maritimum L.Before and after submission to a two-step in vitro digestion model (2011) J.Agric.Food Chem, 59, pp. 12453-12459; Sjka, M., Guyot, S., Ko?odziejczyk, K., Krl, B., Baron, A., Composition and properties of purified phenolics preparations obtained from an extract of industrial blackcurrant (Ribes nigrum L.) pomace (2009) J.Hortic.Sci.Biotechnol., pp. 100-106. , (ISAFRUIT Special issue); Sozzi, G.O., Peter, K.V., Nirmal Babu, K., Divakaran, M., (2012) Capers and Caperberries, Handbook of Herbs and Spices; Tckholm, V., (1974) Student's Flora of Egypt, 162p. , 2nd ed.Cairo University Cooperative Printing Company, Beirut; Tedesco, I., Carbone, V., Spagnuolo, C., Minasi, P., Russo, G.L., Identification and quantification of flavonoids from two Southern Italy cultivars of Allium cepa L.Var.Tropea (red onion) and Montoro (copper onion) and their capacity to protect human erythrocytes from oxidative stress (2015) J.Agric.Food Chem, 63, pp. 5229-5238; Zhang, Q., Cheng, G., Qiu, H., Zhu, L., Ren, Z., Zhao, W., Zhang, T., Liu, L., The p53-inducible gene 3 involved in flavonoid-induced cytotoxicity through the reactive oxygen species-mediated mitochondrial apoptotic pathway in human hepatoma cells (2015) Food Funct, 6, pp. 1518-1525; Zhao, H.-Y., Fan, M.-X., Wu, X., Wang, H.-J., Yang, J., Si, N., Bian, B.-L., Chemical profiling of the Chinese herb formula Xiao-Cheng-Qi decoction using Liquid Chromatography coupled with Electrospray Ionization Mass Spectrometry (2013) J.Chromatogr.Sci, 51, pp. 273-285; Zhou, H., Jian, R., Kang, J., Huang, X., Li, Y., Zhuang, C., Yang, F., Wu, X., Anti-inflammatory effects of caper (Capparis spinosa L.) fruit aqueous extract and the isolation of main phytochemicals (2010) J.Agric.Food Chem, 58, pp. 12717-12721; Zhou, H.F., Xie, C., Jian, R., Kang, J., Li, Y., Zhuang, C.L., Yang, F., Wu, X., Biflavonoids from Caper (Capparis spinosa L.) fruits and their effects in inhibiting NF-kappa B activation (2011) J.Agric.Food Chem, 59, pp. 3060-3065
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