Chemometric discrimination of three Pistacia species via their metabolic profiling and their possible in vitro effects on memory functions

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl Bishbishy M.H.
dc.contributor.authorGad H.A.
dc.contributor.authorAborehab N.M.
dc.contributor.otherPharmacognosy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt; Pharmacognosy Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherAin Shams University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Biochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherOctober University for Modern Sciences and Arts (MSA)
dc.contributor.otherGiza
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:29Z
dc.date.available2020-01-09T20:40:29Z
dc.date.issued2020
dc.descriptionScopus
dc.description.abstractAlzheimer's disease (AD) is the most widespread neurodegenerative disease; there are around ten million new cases of Alzheimer yearly worldwide especially in middle or low-income countries. Pistacia is a genus of flowering plants including the well-known, economically important P. chinensis Bunge, P. lentiscus L. and P. khinjuk. In this study, the metabolic profiling of Pistacia leaves extracts was achieved via UHPLC-ESI-MS analysis and GC�MS analysis employing chemometric analysis for their discrimination. In addition, the methanolic extracts of different Pistacia species were assessed for their anti-cholinesterase and anti-inflammatory activities by various in vitro assays. 37 and 30 metabolites belonging to different classes were identified by UHPLC-ESI-MS and GC�MS analyses respectively. Chemometric analysis revealed that P. lentiscus and P. khinjuk were more closely related chemically to each other. All studied Pistacia leaves extracts showed apparent anti-cholinesterase and anti-inflammatory activities, which promotes their use in the prevention and management of AD. � 2019 Elsevier B.V.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=23061&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.jpba.2019.112840
dc.identifier.doiPubMed ID 31522096
dc.identifier.issn7317085
dc.identifier.otherhttps://doi.org/10.1016/j.jpba.2019.112840
dc.identifier.otherPubMed ID 31522096
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0731708519306648
dc.language.isoEnglishen_US
dc.publisherCIC Edizioni Internazionali s.r.l.
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesJournal of Pharmaceutical and Biomedical Analysis
dc.relation.ispartofseries177
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectUniversity of Modern Sciences and Arts
dc.subjectMSA University
dc.subjectAnti-choline esteraseen_US
dc.subjectAnti-inflammatory activitiesen_US
dc.subjectGC�MSen_US
dc.subjectPistaciaen_US
dc.subjectUHPLC-ESI-MSen_US
dc.subjectanthocyaninen_US
dc.subjectantiinflammatory agenten_US
dc.subjectcatechinen_US
dc.subjectcholinesterase inhibitoren_US
dc.subjectflavonoiden_US
dc.subjectglycosideen_US
dc.subjectisoquercitrinen_US
dc.subjectkaempferol 3 o di hexose o pentoseen_US
dc.subjectkaempferol 3 o hexose o deoxy hexose o pentosideen_US
dc.subjectkaempferol 3 o malonylhexosideen_US
dc.subjectluteolin 7 o glycuronideen_US
dc.subjectmyricetin 3 o galactosideen_US
dc.subjectmyricetin galloyl hexosideen_US
dc.subjectmyricetin rutinosideen_US
dc.subjectphenol derivativeen_US
dc.subjectPistacia chinensis extracten_US
dc.subjectPistacia khinjuk extracten_US
dc.subjectPistacia lentiscus extracten_US
dc.subjectplant extracten_US
dc.subjectquercetin 3 o di hexose o pentoseen_US
dc.subjectquercetin 3 o glucuronideen_US
dc.subjectquercetin 3 o hexose o pentosideen_US
dc.subjectquercetin 3 o malonyl hexosideen_US
dc.subjectquercetin 3,4 diglucosideen_US
dc.subjectquercetin galloyl deoxyhexoseen_US
dc.subjectquercetin galloyl hexosideen_US
dc.subjectquercetin galloyl hexuronideen_US
dc.subjectquercetin glucoside o rutinosideen_US
dc.subjectrutosideen_US
dc.subjectunclassified drugen_US
dc.subjectunindexed drugen_US
dc.subjectantiinflammatory activityen_US
dc.subjectArticleen_US
dc.subjectchemometric analysisen_US
dc.subjectcholinesterase inhibitionen_US
dc.subjectcontrolled studyen_US
dc.subjectelectrospray mass spectrometryen_US
dc.subjectin vitro studyen_US
dc.subjectmass fragmentographyen_US
dc.subjectmemoryen_US
dc.subjectmetabolic fingerprintingen_US
dc.subjectPistaciaen_US
dc.subjectPistacia chinensisen_US
dc.subjectPistacia khinjuken_US
dc.subjectPistacia lentiscusen_US
dc.subjectplant leafen_US
dc.subjectpriority journalen_US
dc.subjectultra performance liquid chromatographyen_US
dc.titleChemometric discrimination of three Pistacia species via their metabolic profiling and their possible in vitro effects on memory functionsen_US
dc.typeArticleen_US
dcterms.isReferencedByA.s.D. International, World Alzheimer Report 2015: The Global Impact of Dementia (2015), (Accessed 11 April 2018.); Nwidu, L.L., Elmorsy, E., Thornton, J., Wijamunige, B., Wijesekara, A., Tarbox, R., Warren, A., Carter, W.G., Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea (2017) Pharm. Biol., 55 (1), pp. 1875-1883; Tabet, N., Acetylcholinesterase inhibitors for Alzheimer's disease: anti-inflammatories in acetylcholine clothing (2006) Age Ageing, 35 (4), pp. 336-338; Chowdhury, S., Shivani, Kumar, S., In vitro anti-acetylcholinesterase activity of an aqueous extract of Unicaria tomentosa and in silico study of its active constituents (2016) Bioinformation, 12 (3), pp. 112-118; Loizzo, M.R., Ben Jemia, M., Senatore, F., Bruno, M., Menichini, F., Tundis, R., Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils (2013) Food Chem. Toxicol., 59, pp. 586-594; Zhang, P., Xu, S., Zhu, Z., Xu, J., Multi-target design strategies for the improved treatment of Alzheimer's disease (2019) Eur. J. Med. Chem., 176, pp. 228-247; Ljubuncic, P., Azaizeh, H., Portnaya, I., Cogan, U., Said, O., Saleh, K.A., Bomzon, A., Antioxidant activity and cytotoxicity of eight plants used in traditional Arab medicine in Israel (2005) J. Ethnopharmacol., 99 (1), pp. 43-47; Abed, A., Rachid, D., Catherine, M., Ismahene, S., Lattab, A., Bechelaghem, N., Hichem, D., Dahloum, L., Chemical composition and antibacterial activity of essential oil from leaves and twigs of Pistacia lentiscus growing in Mostaganem Province (Algeria) (2017) Int. J. Biosci., 10 (5), pp. 146-158; Aissi, O., Boussaid, M., Messaoud, C., Essential oil composition in natural populations of Pistacia lentiscus L. from Tunisia: effect of ecological factors and incidence on antioxidant and antiacetylcholinesterase activities (2016) Ind. Crops Prod., 91, pp. 56-65; Kirollos, F.N., Elhawary, S.S., Salama, O.M., Elkhawas, Y.A., LC-ESI-MS/MS and cytotoxic activity of three Pistacia species (2018) Nat. Prod. Res., pp. 1-4; Ellman, G.L., Courtney, K.D., Andres, V., Jr, Feather-Stone, R.M., A new and rapid colorimetric determination of acetylcholinesterase activity (1961) Biochem. Pharmacol., 7, pp. 88-95; Leelaprakash, G., Dass, S.M., In vitro anti-inflammatory activity of methanol extract of Enicostemma axillare (2011) Int. J. Drug Dev. Res., 3 (3), pp. 189-196; Rauf, A., Patel, S., Uddin, G., Siddiqui, B.S., Ahmad, B., Muhammad, N., Mabkhot, Y.N., Hadda, T.B., Phytochemical, ethnomedicinal uses and pharmacological profile of genus Pistacia (2017) Biomed. Pharmacother., 86, pp. 393-404; Hasnat, A., Pervin, M., Lim, B.O., Acetylcholinesterase inhibition and in vitro and in vivo antioxidant activities of Ganoderma lucidum grown on germinated brown rice (2013) Molecules, 18 (6), pp. 6663-6678; Olennikov, D.N., Kashchenko, N.I., Chirikova, N.K., Akobirshoeva, A., Zilfikarov, I.N., Vennos, C., Isorhamnetin and quercetin derivatives as anti-acetylcholinesterase principles of marigold (Calendula officinalis) flowers and preparations (2017) Int. J. Mol. Sci., 18 (8), p. 1685; Szwajgier, D., Anticholinesterase activities of selected polyphenols�a short report (2014) Pol. J. Food Nutr. Sci., 64 (1), pp. 59-64; Chandra, S., Chatterjee, P., Dey, P., Bhattacharya, S., Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein (2012) Asian Pac. J. Trop. Biomed., pp. S178-S180; Martucci, M.E.P., De Vos, R.C.H., Carollo, C.A., Gobbo-Neto, L., Metabolomics as a potential chemotaxonomical tool: application in the genus Vernonia schreb (2014) PLoS One, 9 (4). , e93149; Khallouki, F., Breuer, A., Merieme, E., Ulrich, C.M., Owen, R.W., Characterization and quantitation of the polyphenolic compounds detected in methanol extracts of Pistacia atlantica Desf. fruits from the Guelmim region of Morocco (2017) J. Pharm. Biomed. Anal., 134, pp. 310-318; Er?an, S., G��l� �st�nda?, �., Carle, R., Schweiggert, R.M., Identification of phenolic compounds in red and green pistachio (Pistacia vera L.) hulls (Exo- and Mesocarp) by HPLC-DAD-ESI-(HR)-MSn (2016) J. Agric. Food Chem., 64 (26), pp. 5334-5344; Bakr, R.O., El Bishbishy, M.H., Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt (2016) Rev. Bras. Farmacogn., 26, pp. 514-520; da Silva Siqueira, E.M., Felix-Silva, J., de Araujo, L.M., Fernandes, J.M., Cabral, B., Gomes, J.A., de Araujo Roque, A., Zucolotto, S.M., Spondias tuberosa (Anacardiaceae) leaves: profiling phenolic compounds by HPLC-DAD and LC-MS/MS and in vivo anti-inflammatory activity (2016) Biomed. Chromatogr., 30 (10), pp. 1656-1665; Foddai, M., Kasabri, V., Afifi, F.U., Azara, E., Petretto, G.L., Pintore, G., In vitro inhibitory effects of Sardinian Pistacia lentiscus L. and Pistacia terebinthus L. on metabolic enzymes: Pancreatic lipase, ??amylase, and ??glucosidase (2015) Starch/St�rke, 67 (1-2), pp. 204-21
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