Spectrophotometric methods for simultaneous determination of betamethasone valerate and fusidic acid in their binary mixture

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorLotfy H.M.
dc.contributor.authorSalem H.
dc.contributor.authorAbdelkawy M.
dc.contributor.authorSamir A.
dc.contributor.otherAnalytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr El-Aini Street
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Pharmaceutical Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherDeraya University
dc.contributor.otherMinia
dc.contributor.otherEgypt; Analytical Chemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.other6th October City
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:41:51Z
dc.date.available2020-01-09T20:41:51Z
dc.date.issued2015
dc.descriptionScopus
dc.description.abstractFive spectrophotometric methods were successfully developed and validated for the determination of betamethasone valerate and fusidic acid in their binary mixture. Those methods are isoabsorptive point method combined with the first derivative (ISO Point - D1) and the recently developed and well established methods namely ratio difference (RD) and constant center coupled with spectrum subtraction (CC) methods, in addition to derivative ratio (1DD) and mean centering of ratio spectra (MCR). New enrichment technique called spectrum addition technique was used instead of traditional spiking technique. The proposed spectrophotometric procedures do not require any separation steps. Accuracy, precision and linearity ranges of the proposed methods were determined and the specificity was assessed by analyzing synthetic mixtures of both drugs. They were applied to their pharmaceutical formulation and the results obtained were statistically compared to that of official methods. The statistical comparison showed that there is no significant difference between the proposed methods and the official ones regarding both accuracy and precision. � 2015 Elsevier B.V. All rights reserved.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=24530&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.saa.2014.12.059
dc.identifier.doiPubMed ID 25615682
dc.identifier.issn13861425
dc.identifier.otherhttps://doi.org/10.1016/j.saa.2014.12.059
dc.identifier.otherPubMed ID 25615682
dc.identifier.urihttps://t.ly/0EwkO
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
dc.relation.ispartofseries140
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectBetamethasoneen_US
dc.subjectConstant centeren_US
dc.subjectFusidic aciden_US
dc.subjectIsoabsorptive pointen_US
dc.subjectMean centeringen_US
dc.subjectRatio differenceen_US
dc.subjectMixturesen_US
dc.subjectSpectrophotometersen_US
dc.subjectSpectrophotometryen_US
dc.subjectBetamethasoneen_US
dc.subjectConstant centeren_US
dc.subjectFusidic aciden_US
dc.subjectIsoabsorptive pointen_US
dc.subjectMean centeringen_US
dc.subjectRatio differencesen_US
dc.subjectBinary mixturesen_US
dc.subjectantiinfective agenten_US
dc.subjectbetamethasone valerateen_US
dc.subjectdrug combinationen_US
dc.subjectfusidic aciden_US
dc.subjectglucocorticoiden_US
dc.subjectdrug combinationen_US
dc.subjectproceduresen_US
dc.subjectreproducibilityen_US
dc.subjectspectrophotometryen_US
dc.subjectstatistical modelen_US
dc.subjectvalidation studyen_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectBetamethasone Valerateen_US
dc.subjectDrug Combinationsen_US
dc.subjectFusidic Aciden_US
dc.subjectGlucocorticoidsen_US
dc.subjectLinear Modelsen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectSpectrophotometryen_US
dc.titleSpectrophotometric methods for simultaneous determination of betamethasone valerate and fusidic acid in their binary mixtureen_US
dc.typeArticleen_US
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