Evaluating the role of curcum powder as a protective factor against bladder cancer - an experimental study

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorEl-Mesallamy H.
dc.contributor.authorSalman T.M.
dc.contributor.authorAshmawey A.M.
dc.contributor.authorOsama N.
dc.contributor.otherBiochemistry Department
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherEgypt; Ain Shams University
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherEgypt; Cancer Biology Department
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.otherEgypt; Al-Azhar University
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherEgypt; MSA University
dc.contributor.otherNational Cancer Institute
dc.contributor.otherCairo University
dc.contributor.otherEgypt
dc.date.accessioned2020-01-25T19:58:28Z
dc.date.available2020-01-25T19:58:28Z
dc.date.issued2012
dc.descriptionScopus
dc.description.abstractThroughout human history, plant products have been used for many purposes including as medicines. Herbal products and spices can be used as preventive agents against cancer due to their antimicrobial, antioxidant and antitumorigenic properties. This study was designed to evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) and sodium nitrate (NaNO3); and infected with Escherichia coli (E. coli) and also to monitor changes in nuclear factor the Kappa B p65 (NF-?B p56) pathway and its downstream products, Bcl-2 and interleukin-6 (IL-6), in parallel with nitrosamine precursors, E. coli and curcum treatment. Rats were divided into three groups (n=25 each; except of control group, n+20). Group I a normal control group, group II administered DBA/NaNO3 in drinking water and infected with E. coli and group III was administered DBA/NaNO3 in drinking water, infected with E. coli and receiving standard diet containing 1% curcum powder. Histopathological examination reflected that the curcum treated group featured a lower incidence of urinary bladder lesions,and lower levels of NF-?B, Bcl-2 and IL-6, than the group receiving nitrosamine precursor and infected with E. coli. These findings suggested that curcum may have a protective role during the process of bladder carcinogenesis by inhibiting the NF-?B pathway and its downstream products.en_US
dc.identifier.doihttps://doi.org/10.7314/APJCP.2012.13.10.5287
dc.identifier.doiPubMed ID :
dc.identifier.issn15137368
dc.identifier.otherhttps://doi.org/10.7314/APJCP.2012.13.10.5287
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/vejGq
dc.language.isoEnglishen_US
dc.publisherAsian Pacific Organization for Cancer Preventionen_US
dc.relation.ispartofseriesAsian Pacific Journal of Cancer Prevention
dc.relation.ispartofseries13
dc.subjectBcl-2en_US
dc.subjectBladder carcinogenesisen_US
dc.subjectCurcumen_US
dc.subjectE. colien_US
dc.subjectIL-6en_US
dc.subjectNF-?B p65en_US
dc.titleEvaluating the role of curcum powder as a protective factor against bladder cancer - an experimental studyen_US
dc.typeArticleen_US
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