Effect of oxylipins, terpenoid precursors and wounding on soft corals' secondary metabolism as analyzed via UPLC/MS and chemometrics

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorFarag M.A.
dc.contributor.authorWestphal H.
dc.contributor.authorEissa T.F.
dc.contributor.authorWessjohann L.A.
dc.contributor.authorMeyer A.
dc.contributor.otherDepartment of Pharmacognosy
dc.contributor.otherCollege of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherKasr El Aini St.
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Department of Chemistry
dc.contributor.otherSchool of Sciences and Engineering
dc.contributor.otherAmerican University in Cairo
dc.contributor.otherNew Cairo
dc.contributor.other11835
dc.contributor.otherEgypt; Leibniz Centre for Tropical Marine Research
dc.contributor.otherFahrenheit Str.6
dc.contributor.otherBremen
dc.contributor.otherD-28359
dc.contributor.otherGermany; Department of Geosciences
dc.contributor.otherBremen University
dc.contributor.otherFahrenheit Str.6
dc.contributor.otherBremen
dc.contributor.otherD-28359
dc.contributor.otherGermany; Department of Pharmacognosy
dc.contributor.otherCollege of Pharmacy
dc.contributor.otherModern Science and Arts University
dc.contributor.otherCairo
dc.contributor.other12566
dc.contributor.otherEgypt; Department of Bioorganic Chemistry
dc.contributor.otherLeibniz Institute of Plant Biochemistry
dc.contributor.otherWeinberg 3
dc.contributor.otherHalle
dc.contributor.otherD-06120
dc.contributor.otherGermany
dc.date.accessioned2020-01-09T20:41:12Z
dc.date.available2020-01-09T20:41:12Z
dc.date.issued2017
dc.descriptionScopus
dc.description.abstractThe effect of three oxylipin analogues, a terpenoid intermediate and wounding on the secondary metabolism of the soft corals Sarcophyton glaucum and Lobophyton pauciflorum was assessed. Examined oxylipins included prostaglandin (PG-E1), methyl jasmonate (MeJA), and arachidonic acid (AA) in addition to the diterpene precursor geranylgeranylpyrophosphate (GGP). Post-elicitation, metabolites were extracted from coral heads and analyzed via UPLC-MS followed by multivariate data analyses. Both supervised and unsupervised data analyses were used for sample classification. Multivariate data analysis revealed clear segregation of PG-E1 and MeJA elicited S. glaucum at 24 and 48 h post elicitation from other elicitor samples and unelicited control group. PG-E1 was found more effective in upregulating S. glaucum terpene/sterol levels compared to MeJA. Metabolites showing upregulation in S. glaucum include campestene-triol and a cembranoid, detected at ca. 30- and 2-fold higher levels compared to unelicited corals. Such an elicitation effect was less notable in the other coral species L. pauciflorum, suggesting a differential oxylipin response in soft corals. Compared to MeJA and PG, no elicitation effect was observed for GGP, AA or wounding on the metabolism of either coral species. � 2017 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=26370&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.3390/molecules22122195
dc.identifier.doiPubMed ID 29232862
dc.identifier.issn14203049
dc.identifier.otherhttps://doi.org/10.3390/molecules22122195
dc.identifier.otherPubMed ID 29232862
dc.identifier.urihttps://t.ly/AXZxy
dc.language.isoEnglishen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofseriesMolecules
dc.relation.ispartofseries22
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectCembranoidsen_US
dc.subjectChemometricsen_US
dc.subjectOxylipinsen_US
dc.subjectSoft coralsen_US
dc.subjectSterolsen_US
dc.subjectacetic aciden_US
dc.subjectarachidonic aciden_US
dc.subjectcyclopentane derivativeen_US
dc.subjectjasmonic acid methyl esteren_US
dc.subjectoxylipinen_US
dc.subjectprostaglandin E1en_US
dc.subjectterpeneen_US
dc.subjectanimalen_US
dc.subjectAnthozoaen_US
dc.subjectchemistryen_US
dc.subjectdrug effecten_US
dc.subjecthigh performance liquid chromatographyen_US
dc.subjectmass spectrometryen_US
dc.subjectmetabolismen_US
dc.subjectprincipal component analysisen_US
dc.subjectsecondary metabolismen_US
dc.subjectAcetatesen_US
dc.subjectAlprostadilen_US
dc.subjectAnimalsen_US
dc.subjectAnthozoaen_US
dc.subjectArachidonic Aciden_US
dc.subjectChromatography, High Pressure Liquiden_US
dc.subjectCyclopentanesen_US
dc.subjectMass Spectrometryen_US
dc.subjectOxylipinsen_US
dc.subjectPrincipal Component Analysisen_US
dc.subjectSecondary Metabolismen_US
dc.subjectTerpenesen_US
dc.titleEffect of oxylipins, terpenoid precursors and wounding on soft corals' secondary metabolism as analyzed via UPLC/MS and chemometricsen_US
dc.typeArticleen_US
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