Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis

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dc.AffiliationOctober university for modern sciences and Arts (MSA)
dc.contributor.authorEl-Kashef, Dalia H
dc.contributor.authorYoussef, Mahmoud E
dc.contributor.authorNasr, Mohamed
dc.contributor.authorAlrouji, Mohammed
dc.contributor.authorAlhajlah, Sharif
dc.contributor.authorAlOmeirf, Othman
dc.contributor.authorEl Adle Khalaf, Noura
dc.contributor.authorAbdel Ghaffar, Dalia M
dc.contributor.authorJamil, Lubna
dc.contributor.authorAbdel-Nasser, Zeinab M
dc.contributor.authorIbrahim, Samar
dc.contributor.authorAbdeldaiem, Mahmoud Said Ibrahim
dc.contributor.authorDonia, Sally S
dc.contributor.authorMohammed, Osama A
dc.contributor.authorMorsy, Nesreen Elsayed
dc.contributor.authorShata, Ahmed
dc.contributor.authorSaber, Sameh
dc.date.accessioned2022-08-03T08:17:01Z
dc.date.available2022-08-03T08:17:01Z
dc.date.issued2022-07-27
dc.description.abstractIdiopathic pulmonary fibrosis is a fatal lung disorder in which the etiology and pathogenesis are still unobvious. Effective treatments are urgently needed considering that lung transplantation is the only treatment that could improve outcomes. This study aimed to investigate the therapeutic significance of the dual administration of pimitespib, an HSP90 inhibitor, and nifuroxazide, a STAT3 inhibitor, against bleomycin-induced pulmonaryen_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=28620&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2022.113487
dc.identifier.otherhttps://doi.org/10.1016/j.biopha.2022.113487
dc.identifier.urihttp://repository.msa.edu.eg/xmlui/handle/123456789/5071
dc.language.isoen_USen_US
dc.publisherElsevier Masson s.r.l.en_US
dc.relation.ispartofseriesBiomedicine & Pharmacotherapy;153 (2022) 113487
dc.subjectBleomycinen_US
dc.subjectNifuroxazideen_US
dc.subjectPimitespiben_US
dc.subjectSTAT3en_US
dc.titlePimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosisen_US
dc.typeArticleen_US

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