Therapeutic Effect of Trigonella foenum-graecum l Seeds Extract on Folic Acid-Induced Acute Kidney Injury

Abstract

Acute kidney injury (AKI) is a serious clinical illness that produces renal failure quickly and has a high fatality rate. Fenugreek possesses anti-osteoporotic, anti-inflammatory, antipyretic, antidiabetic, and immunomodulatory activities. The current study aimed to evaluate the therapeutic efficacy of the Trigonella foenum-graecum L seeds extract (TFGE) against AKI induced by a high dose of folic acid. There were 18 male rats divided into three groups: control, folic acid, and folic acid + TFGE. Hepatorenal toxicity induced by a dose of folic acid (250 mg kg−1, i.p.) while TFGE (250 mg kg−1) administrated for seven consecutive days. The methanolic extract of TFG extract contains tannins, alkaloids, terpenoids, saponins, and phenols, while flavonoids were absent. High dose of folic acid caused increases in AST, ALT, creatinine, urea, uric acid, MDA and decreases in albumin, GSH, CAT levels. In contrast, the administration of TFGE suppresses hepatorenal toxicity and improved tissue functions and structure. TFGE, an abundant antioxidant source, has a renal protecting outcome. The current study demonstrated the therapeutic efficacy of TFGE on the liver and kidney in the treatment of gentamycin-induced hepatotoxicity. © 2022, The Author(s), under exclusive licence to The National Academy of Sciences, India.