LC-MS/MS-based chemometric analysis of phytochemical diversity in 13 Ficus spp. (Moraceae): Correlation to their in vitro antimicrobial and in silico quorum sensing inhibitory activities

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dc.AffiliationOctober University for modern sciences and Arts (MSA)
dc.contributor.authorElhawary S.S.
dc.contributor.authorYounis I.Y.
dc.contributor.authorEl Bishbishy M.H.
dc.contributor.authorKhattab A.R.
dc.contributor.otherDepartment of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherCairo University
dc.contributor.otherCairo
dc.contributor.other11562
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherFaculty of Pharmacy
dc.contributor.otherMSA University
dc.contributor.otherGiza
dc.contributor.other12585
dc.contributor.otherEgypt; Department of Pharmacognosy
dc.contributor.otherDivision of Pharmaceutical Sciences
dc.contributor.otherCollege of Pharmacy
dc.contributor.otherArab Academy for Science
dc.contributor.otherTechnology and Maritime Transport
dc.contributor.otherAlexandria
dc.contributor.other1029
dc.contributor.otherEgypt
dc.date.accessioned2020-01-09T20:40:47Z
dc.date.available2020-01-09T20:40:47Z
dc.date.issued2018
dc.descriptionScopus
dc.description.abstractThirteen Ficus species, family Moraceae, were profiled via HPLC-ESI-MS/MS. About 35 metabolites were tentatively identified, for the first time, belonging to various classes including flavonoids (flavonols, flavanols, flavanonols, flavones, flavanones), flavonolignans, anthocyanins and hydroxycinnamic acids derivatives). We herein also report three species, viz. Ficus auriculata, Ficus lutea Vahl. and Ficus trigonata L., with promising antimicrobial activity for the management of the infectious diseases associated with the tested food-borne and spoilage microorganisms using agar well diffusion assay. The compositional variabilities existing among the studied species in correlation to their antimicrobial activities were explored using different chemometric tools. From the Orthogonal Projection to Latent Structures (OPLS) regression model, a correlation between the observed antimicrobial activity and the abundant Ficus phytoconstituents viz. quercetin-3-glucoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glucoside, rutin and chlorogenic acid, was evidenced. By showing promising in silico anti-quorum sensing efficacy, these phytoconstituents could represent a promising set of natural hence safe antimicrobial agents. 2018en_US
dc.description.urihttps://www.scimagojr.com/journalsearch.php?q=32791&tip=sid&clean=0
dc.identifier.doihttps://doi.org/10.1016/j.indcrop.2018.10.017
dc.identifier.doiPubMed ID :
dc.identifier.issn9266690
dc.identifier.otherhttps://doi.org/10.1016/j.indcrop.2018.10.017
dc.identifier.otherPubMed ID :
dc.identifier.urihttps://t.ly/KX8b1
dc.language.isoEnglishen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofseriesIndustrial Crops and Products
dc.relation.ispartofseries126
dc.subjectOctober University for Modern Sciences and Arts
dc.subjectUniversity for Modern Sciences and Arts
dc.subjectMSA University
dc.subjectجامعة أكتوبر للعلوم الحديثة والآداب
dc.subjectDockingen_US
dc.subjectFigen_US
dc.subjectHierarchical clustering analysisen_US
dc.subjectMoraceaeen_US
dc.subjectPrincipal component analysisen_US
dc.subjectAntimicrobial agentsen_US
dc.subjectCarbohydratesen_US
dc.subjectDockingen_US
dc.subjectFlavonoidsen_US
dc.subjectMicroorganismsen_US
dc.subjectRegression analysisen_US
dc.subjectSpoilageen_US
dc.subjectAnti-microbial activityen_US
dc.subjectChemometric analysisen_US
dc.subjectCompositional variabilityen_US
dc.subjectHierarchical clustering analysisen_US
dc.subjectHydroxycinnamic acidsen_US
dc.subjectMoraceaeen_US
dc.subjectOrthogonal projectionen_US
dc.subjectSpoilage microorganismsen_US
dc.subjectPrincipal component analysisen_US
dc.subjectagaren_US
dc.subjectantimicrobial activityen_US
dc.subjectbiochemical compositionen_US
dc.subjectcluster analysisen_US
dc.subjectdeciduous treeen_US
dc.subjecthierarchical systemen_US
dc.subjectliquid chromatographyen_US
dc.subjectmass spectrometryen_US
dc.subjectmolecular analysisen_US
dc.subjectprincipal component analysisen_US
dc.subjectsignalingen_US
dc.subjectFicus (angiosperm)en_US
dc.subjectFicus auriculataen_US
dc.subjectFicus luteaen_US
dc.subjectFicus trigonataen_US
dc.subjectMoraceaeen_US
dc.titleLC-MS/MS-based chemometric analysis of phytochemical diversity in 13 Ficus spp. (Moraceae): Correlation to their in vitro antimicrobial and in silico quorum sensing inhibitory activitiesen_US
dc.typeArticleen_US
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